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Urinary TIMP-2 and IGFBP7 elevate early in critically ill postoperative patients that develop AKI

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Mentions: There were 101 patients without AKI, 95 patients with KDIGO 1 AKI, and 42 patients with KDIGO 2 to 3 AKI within 48 hours of the start of surgery. In patients without AKI, median TIMP-2·IGFBP7 values were less than 0.3 (ng/ml)2/1,000 (dashed line in Figure 1) for all time points. In patients with KDIGO 1 AKI, median [TIMP-2·IGFBP7] significantly exceeded this cutoff at 24 and 36 hours following the start of surgery (*one-sided P < 0.025). Median [TIMP-2·IGFBP7] increased earlier in KDIGO 2 to 3 AKI patients, remaining significantly elevated relative to the cutoff from 12 to 60 hours after the start of surgery. The highest median [TIMP-2·IGFBP7] was observed at 24 hours for KDIGO 2 to 3 AKI patients and was nearly five times the 0.3 (ng/ml)2/1,000 cutoff.


Urinary TIMP-2 and IGFBP7 elevate early in critically ill postoperative patients that develop AKI
© Copyright Policy - open-access
Related In: Results  -  Collection

License 1 - License 2
Show All Figures
getmorefigures.php?uid=PMC4470670&req=5

Mentions: There were 101 patients without AKI, 95 patients with KDIGO 1 AKI, and 42 patients with KDIGO 2 to 3 AKI within 48 hours of the start of surgery. In patients without AKI, median TIMP-2·IGFBP7 values were less than 0.3 (ng/ml)2/1,000 (dashed line in Figure 1) for all time points. In patients with KDIGO 1 AKI, median [TIMP-2·IGFBP7] significantly exceeded this cutoff at 24 and 36 hours following the start of surgery (*one-sided P < 0.025). Median [TIMP-2·IGFBP7] increased earlier in KDIGO 2 to 3 AKI patients, remaining significantly elevated relative to the cutoff from 12 to 60 hours after the start of surgery. The highest median [TIMP-2·IGFBP7] was observed at 24 hours for KDIGO 2 to 3 AKI patients and was nearly five times the 0.3 (ng/ml)2/1,000 cutoff.

View Article: PubMed Central - HTML

No MeSH data available.