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Gender-Specific Associations between Circulating T-Cadherin and High Molecular Weight-Adiponectin in Patients with Stable Coronary Artery Disease.

Schoenenberger AW, Pfaff D, Dasen B, Frismantiene A, Erne P, Resink TJ, Philippova M - PLoS ONE (2015)

Bottom Line: Regression analysis showed no significant association between HMW-APN and T-cad in the overall study population.After exclusion of the young men, a positive association (P=0.008) between HMW-APN and T-cad was found for the remaining participants of the overall population which disappeared after adjustment for HDL and BMI.The existence of opposing correlations between circulating HMW-APN and T-cad in male and female patient populations underscores the necessity to consider gender as a confounding variable when evaluating biomarker potentials of APN and T-cad.

View Article: PubMed Central - PubMed

Affiliation: Division of Geriatrics, Department of General Internal Medicine, Inselspital, Bern University Hospital and University of Bern, Bern, Switzerland.

ABSTRACT
Close relationships exist between presence of adiponectin (APN) within vascular tissue and expression of T-cadherin (T-cad) on vascular cells. APN and T-cad are also present in the circulation but here their relationships are unknown. This study investigates associations between circulating levels of high molecular weight APN (HMW-APN) and T-cad in a population comprising 66 women and 181 men with angiographically proven stable coronary artery disease (CAD). Plasma HMW-APN and T-cad were measured by ELISA and analysed for associations with baseline clinical characteristics and with each other. In multivariable analysis BMI and HDL were independently associated with HMW-APN in both genders, while diabetes and extent of coronary stenosis were independently associated with T-cad in males only. Regression analysis showed no significant association between HMW-APN and T-cad in the overall study population. However, there was a negative association between HMW-APN and T-cad (P=0.037) in a subgroup of young men (age <60 years, had no diabetes and no or 1-vessel CAD) which persisted after multivariable analysis with adjustment for all potentially influential variables (P=0.021). In the corresponding subgroup of women there was a positive association between HMW-APN and T-cad (P=0.013) which disappeared after adjustment for HDL. After exclusion of the young men, a positive association (P=0.008) between HMW-APN and T-cad was found for the remaining participants of the overall population which disappeared after adjustment for HDL and BMI. The existence of opposing correlations between circulating HMW-APN and T-cad in male and female patient populations underscores the necessity to consider gender as a confounding variable when evaluating biomarker potentials of APN and T-cad.

No MeSH data available.


Related in: MedlinePlus

Regression plots showing relationships between HMW-APN and T-cad.Associations between HMW-APN and T-cad in the subgroups of young (age < 60, had no diabetes and no or 1-vessel CAD) males (A) or females (B) and in the overall population minus the young male subgroup (C) were determined by bivariable linear regression analyses. Data are presented as fitted regression plots (solid lines) with 95% confidence intervals (dashed lines) for the fits and significance levels (P).
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pone.0131140.g001: Regression plots showing relationships between HMW-APN and T-cad.Associations between HMW-APN and T-cad in the subgroups of young (age < 60, had no diabetes and no or 1-vessel CAD) males (A) or females (B) and in the overall population minus the young male subgroup (C) were determined by bivariable linear regression analyses. Data are presented as fitted regression plots (solid lines) with 95% confidence intervals (dashed lines) for the fits and significance levels (P).

Mentions: In the overall study population, no significant association was found between HMW-APN and T-cad (R2 0.01, coefficient 0.002 [95% CI -0.001–0.004], P = 0.144). However, we observed a significant negative association in a subgroup of 42 younger men (age < 60 years) who were relatively healthy (had no diabetes and no or 1-vessel CAD) (R2 0.10, coefficient -0.008 [95% CI -0.015 –-0.001], P = 0.037) (Fig 1A). The significant association persisted in the multivariable model (P = 0.021). In contrast, in the corresponding subgroup of 20 young and healthy women a relatively strong positive association was found (R2 0.30, coefficient 0.008 [95% CI 0.002–0.013], P = 0.013) (Fig 1B). In this group, the significant association persisted for all adjustment variables with the exception of HDL, where there was no longer an association between HMW-APN and T-cad (P = 0.592). After exclusion of the 42 young and healthy men, a significant positive association between HMW-APN and T-cad was found for the 205 remaining participants of the overall population (R2 0.03, coefficient 0.004 [95% CI 0.001–0.006], P = 0.008) (Fig 1C). This significant association disappeared after adjustment for BMI (P = 0.117) and HDL (P = 0.131).


Gender-Specific Associations between Circulating T-Cadherin and High Molecular Weight-Adiponectin in Patients with Stable Coronary Artery Disease.

Schoenenberger AW, Pfaff D, Dasen B, Frismantiene A, Erne P, Resink TJ, Philippova M - PLoS ONE (2015)

Regression plots showing relationships between HMW-APN and T-cad.Associations between HMW-APN and T-cad in the subgroups of young (age < 60, had no diabetes and no or 1-vessel CAD) males (A) or females (B) and in the overall population minus the young male subgroup (C) were determined by bivariable linear regression analyses. Data are presented as fitted regression plots (solid lines) with 95% confidence intervals (dashed lines) for the fits and significance levels (P).
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4470588&req=5

pone.0131140.g001: Regression plots showing relationships between HMW-APN and T-cad.Associations between HMW-APN and T-cad in the subgroups of young (age < 60, had no diabetes and no or 1-vessel CAD) males (A) or females (B) and in the overall population minus the young male subgroup (C) were determined by bivariable linear regression analyses. Data are presented as fitted regression plots (solid lines) with 95% confidence intervals (dashed lines) for the fits and significance levels (P).
Mentions: In the overall study population, no significant association was found between HMW-APN and T-cad (R2 0.01, coefficient 0.002 [95% CI -0.001–0.004], P = 0.144). However, we observed a significant negative association in a subgroup of 42 younger men (age < 60 years) who were relatively healthy (had no diabetes and no or 1-vessel CAD) (R2 0.10, coefficient -0.008 [95% CI -0.015 –-0.001], P = 0.037) (Fig 1A). The significant association persisted in the multivariable model (P = 0.021). In contrast, in the corresponding subgroup of 20 young and healthy women a relatively strong positive association was found (R2 0.30, coefficient 0.008 [95% CI 0.002–0.013], P = 0.013) (Fig 1B). In this group, the significant association persisted for all adjustment variables with the exception of HDL, where there was no longer an association between HMW-APN and T-cad (P = 0.592). After exclusion of the 42 young and healthy men, a significant positive association between HMW-APN and T-cad was found for the 205 remaining participants of the overall population (R2 0.03, coefficient 0.004 [95% CI 0.001–0.006], P = 0.008) (Fig 1C). This significant association disappeared after adjustment for BMI (P = 0.117) and HDL (P = 0.131).

Bottom Line: Regression analysis showed no significant association between HMW-APN and T-cad in the overall study population.After exclusion of the young men, a positive association (P=0.008) between HMW-APN and T-cad was found for the remaining participants of the overall population which disappeared after adjustment for HDL and BMI.The existence of opposing correlations between circulating HMW-APN and T-cad in male and female patient populations underscores the necessity to consider gender as a confounding variable when evaluating biomarker potentials of APN and T-cad.

View Article: PubMed Central - PubMed

Affiliation: Division of Geriatrics, Department of General Internal Medicine, Inselspital, Bern University Hospital and University of Bern, Bern, Switzerland.

ABSTRACT
Close relationships exist between presence of adiponectin (APN) within vascular tissue and expression of T-cadherin (T-cad) on vascular cells. APN and T-cad are also present in the circulation but here their relationships are unknown. This study investigates associations between circulating levels of high molecular weight APN (HMW-APN) and T-cad in a population comprising 66 women and 181 men with angiographically proven stable coronary artery disease (CAD). Plasma HMW-APN and T-cad were measured by ELISA and analysed for associations with baseline clinical characteristics and with each other. In multivariable analysis BMI and HDL were independently associated with HMW-APN in both genders, while diabetes and extent of coronary stenosis were independently associated with T-cad in males only. Regression analysis showed no significant association between HMW-APN and T-cad in the overall study population. However, there was a negative association between HMW-APN and T-cad (P=0.037) in a subgroup of young men (age <60 years, had no diabetes and no or 1-vessel CAD) which persisted after multivariable analysis with adjustment for all potentially influential variables (P=0.021). In the corresponding subgroup of women there was a positive association between HMW-APN and T-cad (P=0.013) which disappeared after adjustment for HDL. After exclusion of the young men, a positive association (P=0.008) between HMW-APN and T-cad was found for the remaining participants of the overall population which disappeared after adjustment for HDL and BMI. The existence of opposing correlations between circulating HMW-APN and T-cad in male and female patient populations underscores the necessity to consider gender as a confounding variable when evaluating biomarker potentials of APN and T-cad.

No MeSH data available.


Related in: MedlinePlus