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Comparison of the two most commonly used treatments for pyoderma gangrenosum: results of the STOP GAP randomised controlled trial.

Ormerod AD, Thomas KS, Craig FE, Mitchell E, Greenlaw N, Norrie J, Mason JM, Walton S, Johnston GA, Williams HC, UK Dermatology Clinical Trials Network’s STOP GAP Te - BMJ (2015)

Bottom Line: By six months, ulcers had healed in 28/59 (47%) participants in the ciclosporin group compared with 25/53 (47%) in the prednisolone group.Prednisolone and ciclosporin did not differ across a range of objective and patient reported outcomes.Treatment decisions for individual patients may be guided by the different side effect profiles of the two drugs and patient preference.

View Article: PubMed Central - PubMed

Affiliation: Division of Applied Medicine, Aberdeen University, Aberdeen, UK.

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Related in: MedlinePlus

Fig 1 Flow of participants through study. *Number of patients with information on healing of lesion at any point up to six months after randomisation (main secondary outcome of time to healing)
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fig1: Fig 1 Flow of participants through study. *Number of patients with information on healing of lesion at any point up to six months after randomisation (main secondary outcome of time to healing)

Mentions: Of 499 patients screened from June 2009 to November 2012, 121 were eligible and gave written informed consent (86% of target of 140 participants) (fig 1).


Comparison of the two most commonly used treatments for pyoderma gangrenosum: results of the STOP GAP randomised controlled trial.

Ormerod AD, Thomas KS, Craig FE, Mitchell E, Greenlaw N, Norrie J, Mason JM, Walton S, Johnston GA, Williams HC, UK Dermatology Clinical Trials Network’s STOP GAP Te - BMJ (2015)

Fig 1 Flow of participants through study. *Number of patients with information on healing of lesion at any point up to six months after randomisation (main secondary outcome of time to healing)
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4469977&req=5

fig1: Fig 1 Flow of participants through study. *Number of patients with information on healing of lesion at any point up to six months after randomisation (main secondary outcome of time to healing)
Mentions: Of 499 patients screened from June 2009 to November 2012, 121 were eligible and gave written informed consent (86% of target of 140 participants) (fig 1).

Bottom Line: By six months, ulcers had healed in 28/59 (47%) participants in the ciclosporin group compared with 25/53 (47%) in the prednisolone group.Prednisolone and ciclosporin did not differ across a range of objective and patient reported outcomes.Treatment decisions for individual patients may be guided by the different side effect profiles of the two drugs and patient preference.

View Article: PubMed Central - PubMed

Affiliation: Division of Applied Medicine, Aberdeen University, Aberdeen, UK.

Show MeSH
Related in: MedlinePlus