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Impact of subanesthetic doses of ketamine on AMPA-mediated responses in rats: An in vivo electrophysiological study on monoaminergic and glutamatergic neurons.

El Iskandrani KS, Oosterhof CA, El Mansari M, Blier P - J. Psychopharmacol. (Oxford) (2015)

Bottom Line: It is thus hypothesized that monoamine systems may play a role in the immediate/rapid effects of ketamine.Although acute (~2 hours) ketamine administration did not affect the mean firing activity of dorsal raphe serotonin and ventral tegmental area dopamine neurons, it did increase that of locus coeruleus norepinephrine neurons.These effects of ketamine were prevented by the prior administration of the AMPA receptor antagonist 2,3-dioxo-6-nitro-1,2,3,4-tetrahydrobenzo[f]quinoxaline-7-sulfonamide.

View Article: PubMed Central - PubMed

Affiliation: University of Ottawa Institute of Mental Health Research, Mood Disorders Research, Ottawa, ON, Canada.

No MeSH data available.


Related in: MedlinePlus

Effects of acute and two-day administration of ketamine on DRN 5-HT neuron firing. Mean (± SEM) of the firing rate of 5-HT neurons following acute (a) and (b) and two-day (c) administration of vehicle or ketamine at a dose of 10 mg/kg/day (a) and (c) and 25 mg/kg/day (b). Numbers in the histograms correspond to the number of neurons recorded (5–6 rats tested per group).
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fig1-0269881115573809: Effects of acute and two-day administration of ketamine on DRN 5-HT neuron firing. Mean (± SEM) of the firing rate of 5-HT neurons following acute (a) and (b) and two-day (c) administration of vehicle or ketamine at a dose of 10 mg/kg/day (a) and (c) and 25 mg/kg/day (b). Numbers in the histograms correspond to the number of neurons recorded (5–6 rats tested per group).

Mentions: Acute administration of ketamine (10 mg/kg; i.p.) yielded no significant change in the average firing activity of 5-HT neurons in the DRN when the paradigm in which firing was assessed prior to and following ketamine administration in the same rat. Similarly there was no significant alteration in 5-HT neurons firing in the paradigm in which vehicle and ketamine administered rats were used (Figure 1(a)).


Impact of subanesthetic doses of ketamine on AMPA-mediated responses in rats: An in vivo electrophysiological study on monoaminergic and glutamatergic neurons.

El Iskandrani KS, Oosterhof CA, El Mansari M, Blier P - J. Psychopharmacol. (Oxford) (2015)

Effects of acute and two-day administration of ketamine on DRN 5-HT neuron firing. Mean (± SEM) of the firing rate of 5-HT neurons following acute (a) and (b) and two-day (c) administration of vehicle or ketamine at a dose of 10 mg/kg/day (a) and (c) and 25 mg/kg/day (b). Numbers in the histograms correspond to the number of neurons recorded (5–6 rats tested per group).
© Copyright Policy - open-access
Related In: Results  -  Collection

License 1 - License 2 - License 3
Show All Figures
getmorefigures.php?uid=PMC4469544&req=5

fig1-0269881115573809: Effects of acute and two-day administration of ketamine on DRN 5-HT neuron firing. Mean (± SEM) of the firing rate of 5-HT neurons following acute (a) and (b) and two-day (c) administration of vehicle or ketamine at a dose of 10 mg/kg/day (a) and (c) and 25 mg/kg/day (b). Numbers in the histograms correspond to the number of neurons recorded (5–6 rats tested per group).
Mentions: Acute administration of ketamine (10 mg/kg; i.p.) yielded no significant change in the average firing activity of 5-HT neurons in the DRN when the paradigm in which firing was assessed prior to and following ketamine administration in the same rat. Similarly there was no significant alteration in 5-HT neurons firing in the paradigm in which vehicle and ketamine administered rats were used (Figure 1(a)).

Bottom Line: It is thus hypothesized that monoamine systems may play a role in the immediate/rapid effects of ketamine.Although acute (~2 hours) ketamine administration did not affect the mean firing activity of dorsal raphe serotonin and ventral tegmental area dopamine neurons, it did increase that of locus coeruleus norepinephrine neurons.These effects of ketamine were prevented by the prior administration of the AMPA receptor antagonist 2,3-dioxo-6-nitro-1,2,3,4-tetrahydrobenzo[f]quinoxaline-7-sulfonamide.

View Article: PubMed Central - PubMed

Affiliation: University of Ottawa Institute of Mental Health Research, Mood Disorders Research, Ottawa, ON, Canada.

No MeSH data available.


Related in: MedlinePlus