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The microRNA-200 family: small molecules with novel roles in cancer development, progression and therapy.

Humphries B, Yang C - Oncotarget (2015)

Bottom Line: MicroRNAs (miRNAs) are a large family of small non-coding RNAs that negatively regulate protein-coding gene expression post-transcriptionally via base pairing between the 5' seed region of a miRNA and the 3' untranslated region (3'UTR) of a messenger RNA (mRNA).While miR-200s were found to be critically involved in the metastatic colonization to the lungs in mouse mammary xenograft tumor models, a large number of studies demonstrated their strong suppressive effects on cell transformation, cancer cell proliferation, migration, invasion, tumor growth and metastasis.A comprehensive summary of currently validated miR-200 targets is also presented.

View Article: PubMed Central - PubMed

Affiliation: Department of Physiology, Michigan State University, East Lansing, MI 48824, USA.

ABSTRACT
MicroRNAs (miRNAs) are a large family of small non-coding RNAs that negatively regulate protein-coding gene expression post-transcriptionally via base pairing between the 5' seed region of a miRNA and the 3' untranslated region (3'UTR) of a messenger RNA (mRNA). Recent evidence has supported the critical role that miRNAs play in many diseases including cancer. The miR-200 family consisting of 5 members (miR-200a, -200b, -200c, -141, -429) is an emerging miRNA family that has been shown to play crucial roles in cancer initiation and metastasis, and potentially be important for the diagnosis and treatment of cancer. While miR-200s were found to be critically involved in the metastatic colonization to the lungs in mouse mammary xenograft tumor models, a large number of studies demonstrated their strong suppressive effects on cell transformation, cancer cell proliferation, migration, invasion, tumor growth and metastasis. This review aims to discuss research findings about the role of the miR-200 family in cancer initiation, each step of cancer metastatic cascade, cancer diagnosis and treatment. A comprehensive summary of currently validated miR-200 targets is also presented. It is concluded that miR-200 family may serve as novel targets for the therapy of multiple types of cancer.

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The miR-200 family two clusters are located on two different chromosomesThe miR-200 family consists of two clusters: Cluster I (miR-200b, -200a, and -429 is located on chromosome 1) and Cluster II (miR-200c and -141 is located on chromosome 12).
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Figure 1: The miR-200 family two clusters are located on two different chromosomesThe miR-200 family consists of two clusters: Cluster I (miR-200b, -200a, and -429 is located on chromosome 1) and Cluster II (miR-200c and -141 is located on chromosome 12).

Mentions: The miRNA-200 (miR-200) family consists of five members, which form two clusters located in two different genomic regions. As shown in Figure 1, the Cluster I miR-200s in humans contains miR-200b, -200a, and -429 (miR-200b/200a/429) located in an intergenic region of chromosome 1, and cluster II miR-200s contains miR-200c and -141 (miR-200c/141) located on chromosome 12 [27, 28]. Alternatively, the miR-200 family members can also be divided into two functional groups based upon the similarities of their seed sequences (Figure 2). MiR-200b, -200c, and -429 (Functional Group I) all share the same seed sequence and miR-200a and -141 (Functional Group II) both share the same seed sequence, with the two functional groups only differing in the seed sequence by one nucleotide (AAUACUG for miR-200b/200c/429 and AACACUG for miR-200a/141). The miR-200 family is highly conserved among vertebrate species and highly expressed within epithelial cells.


The microRNA-200 family: small molecules with novel roles in cancer development, progression and therapy.

Humphries B, Yang C - Oncotarget (2015)

The miR-200 family two clusters are located on two different chromosomesThe miR-200 family consists of two clusters: Cluster I (miR-200b, -200a, and -429 is located on chromosome 1) and Cluster II (miR-200c and -141 is located on chromosome 12).
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4466628&req=5

Figure 1: The miR-200 family two clusters are located on two different chromosomesThe miR-200 family consists of two clusters: Cluster I (miR-200b, -200a, and -429 is located on chromosome 1) and Cluster II (miR-200c and -141 is located on chromosome 12).
Mentions: The miRNA-200 (miR-200) family consists of five members, which form two clusters located in two different genomic regions. As shown in Figure 1, the Cluster I miR-200s in humans contains miR-200b, -200a, and -429 (miR-200b/200a/429) located in an intergenic region of chromosome 1, and cluster II miR-200s contains miR-200c and -141 (miR-200c/141) located on chromosome 12 [27, 28]. Alternatively, the miR-200 family members can also be divided into two functional groups based upon the similarities of their seed sequences (Figure 2). MiR-200b, -200c, and -429 (Functional Group I) all share the same seed sequence and miR-200a and -141 (Functional Group II) both share the same seed sequence, with the two functional groups only differing in the seed sequence by one nucleotide (AAUACUG for miR-200b/200c/429 and AACACUG for miR-200a/141). The miR-200 family is highly conserved among vertebrate species and highly expressed within epithelial cells.

Bottom Line: MicroRNAs (miRNAs) are a large family of small non-coding RNAs that negatively regulate protein-coding gene expression post-transcriptionally via base pairing between the 5' seed region of a miRNA and the 3' untranslated region (3'UTR) of a messenger RNA (mRNA).While miR-200s were found to be critically involved in the metastatic colonization to the lungs in mouse mammary xenograft tumor models, a large number of studies demonstrated their strong suppressive effects on cell transformation, cancer cell proliferation, migration, invasion, tumor growth and metastasis.A comprehensive summary of currently validated miR-200 targets is also presented.

View Article: PubMed Central - PubMed

Affiliation: Department of Physiology, Michigan State University, East Lansing, MI 48824, USA.

ABSTRACT
MicroRNAs (miRNAs) are a large family of small non-coding RNAs that negatively regulate protein-coding gene expression post-transcriptionally via base pairing between the 5' seed region of a miRNA and the 3' untranslated region (3'UTR) of a messenger RNA (mRNA). Recent evidence has supported the critical role that miRNAs play in many diseases including cancer. The miR-200 family consisting of 5 members (miR-200a, -200b, -200c, -141, -429) is an emerging miRNA family that has been shown to play crucial roles in cancer initiation and metastasis, and potentially be important for the diagnosis and treatment of cancer. While miR-200s were found to be critically involved in the metastatic colonization to the lungs in mouse mammary xenograft tumor models, a large number of studies demonstrated their strong suppressive effects on cell transformation, cancer cell proliferation, migration, invasion, tumor growth and metastasis. This review aims to discuss research findings about the role of the miR-200 family in cancer initiation, each step of cancer metastatic cascade, cancer diagnosis and treatment. A comprehensive summary of currently validated miR-200 targets is also presented. It is concluded that miR-200 family may serve as novel targets for the therapy of multiple types of cancer.

Show MeSH
Related in: MedlinePlus