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Auditory hedonic phenotypes in dementia: A behavioural and neuroanatomical analysis.

Fletcher PD, Downey LE, Golden HL, Clark CN, Slattery CF, Paterson RW, Schott JM, Rohrer JD, Rossor MN, Warren JD - Cortex (2015)

Bottom Line: Aversion to sounds was the exclusive auditory phenotype in AD whereas more complex phenotypes including musicophilia were common in bvFTD and SD.Auditory hedonic alterations correlated with grey matter loss in a common, distributed, right-lateralised network including antero-mesial temporal lobe, insula, anterior cingulate and nucleus accumbens.Sounds may constitute a novel probe of brain mechanisms for emotional salience coding that are targeted by neurodegenerative disease.

View Article: PubMed Central - PubMed

Affiliation: Dementia Research Centre, UCL Institute of Neurology, University College London, United Kingdom.

No MeSH data available.


Related in: MedlinePlus

Statistical parametric maps (SPMs) showing regional grey matter atrophy significantly associated with: A, any auditory hedonic symptoms in the combined FTLD cohort, centred on right anterior temporal lobe, insula and putamen; B, C, environmental sound aversion in the combined FTLD cohort, including anterior temporal cortex, amygdala and nucleus accumbens; D, environmental sound aversion in the AD cohort, in anterior cingulate cortex. The neuroanatomical associations of music aversion in the FTLD cohort (not shown) comprised a similar distributed fronto-temporal network (see Table 2). SPMs are thresholded at p < .05 after small volume correction for multiple voxel-wise comparisons in pre-specified small anatomical volumes of interest and displayed on sections of a group mean T1-weighted MR brain template image in MNI standard space; the right hemisphere is shown on the right of the axial sections. AD, Alzheimer's disease; FTLD, frontotemporal lobar degeneration.
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fig2: Statistical parametric maps (SPMs) showing regional grey matter atrophy significantly associated with: A, any auditory hedonic symptoms in the combined FTLD cohort, centred on right anterior temporal lobe, insula and putamen; B, C, environmental sound aversion in the combined FTLD cohort, including anterior temporal cortex, amygdala and nucleus accumbens; D, environmental sound aversion in the AD cohort, in anterior cingulate cortex. The neuroanatomical associations of music aversion in the FTLD cohort (not shown) comprised a similar distributed fronto-temporal network (see Table 2). SPMs are thresholded at p < .05 after small volume correction for multiple voxel-wise comparisons in pre-specified small anatomical volumes of interest and displayed on sections of a group mean T1-weighted MR brain template image in MNI standard space; the right hemisphere is shown on the right of the axial sections. AD, Alzheimer's disease; FTLD, frontotemporal lobar degeneration.

Mentions: Regional grey matter correlates of auditory hedonic symptoms from the VBM analysis are summarised in Table 2 and statistical parametric maps are shown in Fig. 2.


Auditory hedonic phenotypes in dementia: A behavioural and neuroanatomical analysis.

Fletcher PD, Downey LE, Golden HL, Clark CN, Slattery CF, Paterson RW, Schott JM, Rohrer JD, Rossor MN, Warren JD - Cortex (2015)

Statistical parametric maps (SPMs) showing regional grey matter atrophy significantly associated with: A, any auditory hedonic symptoms in the combined FTLD cohort, centred on right anterior temporal lobe, insula and putamen; B, C, environmental sound aversion in the combined FTLD cohort, including anterior temporal cortex, amygdala and nucleus accumbens; D, environmental sound aversion in the AD cohort, in anterior cingulate cortex. The neuroanatomical associations of music aversion in the FTLD cohort (not shown) comprised a similar distributed fronto-temporal network (see Table 2). SPMs are thresholded at p < .05 after small volume correction for multiple voxel-wise comparisons in pre-specified small anatomical volumes of interest and displayed on sections of a group mean T1-weighted MR brain template image in MNI standard space; the right hemisphere is shown on the right of the axial sections. AD, Alzheimer's disease; FTLD, frontotemporal lobar degeneration.
© Copyright Policy - CC BY
Related In: Results  -  Collection

License
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getmorefigures.php?uid=PMC4465962&req=5

fig2: Statistical parametric maps (SPMs) showing regional grey matter atrophy significantly associated with: A, any auditory hedonic symptoms in the combined FTLD cohort, centred on right anterior temporal lobe, insula and putamen; B, C, environmental sound aversion in the combined FTLD cohort, including anterior temporal cortex, amygdala and nucleus accumbens; D, environmental sound aversion in the AD cohort, in anterior cingulate cortex. The neuroanatomical associations of music aversion in the FTLD cohort (not shown) comprised a similar distributed fronto-temporal network (see Table 2). SPMs are thresholded at p < .05 after small volume correction for multiple voxel-wise comparisons in pre-specified small anatomical volumes of interest and displayed on sections of a group mean T1-weighted MR brain template image in MNI standard space; the right hemisphere is shown on the right of the axial sections. AD, Alzheimer's disease; FTLD, frontotemporal lobar degeneration.
Mentions: Regional grey matter correlates of auditory hedonic symptoms from the VBM analysis are summarised in Table 2 and statistical parametric maps are shown in Fig. 2.

Bottom Line: Aversion to sounds was the exclusive auditory phenotype in AD whereas more complex phenotypes including musicophilia were common in bvFTD and SD.Auditory hedonic alterations correlated with grey matter loss in a common, distributed, right-lateralised network including antero-mesial temporal lobe, insula, anterior cingulate and nucleus accumbens.Sounds may constitute a novel probe of brain mechanisms for emotional salience coding that are targeted by neurodegenerative disease.

View Article: PubMed Central - PubMed

Affiliation: Dementia Research Centre, UCL Institute of Neurology, University College London, United Kingdom.

No MeSH data available.


Related in: MedlinePlus