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Anorexia Nervosa during Adolescence Is Associated with Decreased Gray Matter Volume in the Inferior Frontal Gyrus.

Fujisawa TX, Yatsuga C, Mabe H, Yamada E, Masuda M, Tomoda A - PLoS ONE (2015)

Bottom Line: The GMV in the bilateral IFG correlated significantly with current age (left IFG: r = -.481, p < .05; right IFG: r = -.601, p < .01) and was limited to the AN group.We speculate that decreased IFG volume might lead to deficits in executive functioning or inhibitory control within neural reward systems.Precocious or unbalanced neurological trimming within this particular region might be an important factor for the pathogenesis of AN onset.

View Article: PubMed Central - PubMed

Affiliation: Research Center for Child Mental Development, University of Fukui, Fukui, Japan; Department of Child Development, United Graduate School of Child Development, Osaka University, Kanazawa University, Hamamatsu University School of Medicine, Chiba University and University of Fukui, Fukui, Japan.

ABSTRACT
Anorexia nervosa (AN) is an eating disorder characterized by the relentless pursuit to lose weight, mostly through self-starvation, and a distorted body image. AN tends to begin during adolescence among women. However, the underlying neural mechanisms related to AN remain unclear. Using voxel-based morphometry based on magnetic resonance imaging scans, we investigated whether the presence of AN was associated with discernible changes in brain morphology. Participants were 20 un-medicated, right-handed patients with early-onset AN and 14 healthy control subjects. Group differences in gray matter volume (GMV) were assessed using high-resolution, T1-weighted, volumetric magnetic resonance imaging datasets (3T Trio scanner; Siemens AG) and analyzed after controlling for age and total GMV, which was decreased in the bilateral inferior frontal gyrus (IFG) (left IFG: FWE corrected, p < 0.05; right IFG: uncorrected, p < 0.05) of patients with AN. The GMV in the bilateral IFG correlated significantly with current age (left IFG: r = -.481, p < .05; right IFG: r = -.601, p < .01) and was limited to the AN group. We speculate that decreased IFG volume might lead to deficits in executive functioning or inhibitory control within neural reward systems. Precocious or unbalanced neurological trimming within this particular region might be an important factor for the pathogenesis of AN onset.

No MeSH data available.


Related in: MedlinePlus

Voxel based morphometry results.Locations displaying significant differences between AN and control participants in regional GMV. Significantly lower GM densities among AN participants were revealed in the bilateral IFG (Brodmann area 45/46). Color scale: 0–5 represents t-values.
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pone.0128548.g001: Voxel based morphometry results.Locations displaying significant differences between AN and control participants in regional GMV. Significantly lower GM densities among AN participants were revealed in the bilateral IFG (Brodmann area 45/46). Color scale: 0–5 represents t-values.

Mentions: After correcting for age and tGMV, regional GMV decreases in the bilateral inferior frontal gyrus (IFG) were observed among AN participants (Table 2). An analysis of region-specific GM changes (ANCOVA with age and total GMV as control variables) yielded two clusters in the bilateral IFG (Fig 1; Table 3). The most prominent neural finding was a significant decrease in GMV in the left IFG in patients with AN (Brodmann area 45/46 [BA45/46]; Talairach’s coordinates x = -52, y = 30, z = 24, Z = 4.40, k = 434 voxels; p < .001 for height, FWE corrected to p < .05 for multiple comparisons). The mean decrease in GMV in this area was 19.1% among AN patients. Similarly, significant decreases in GMV in the right IFG were observed in the AN group (BA45/46; Talairach’s coordinates x = 58, y = 30, z = 20, Z = 4.04, cluster size = 225 voxels; p < .001 for height, corrected to p < .05 for multiple comparisons using cluster size). The mean decrease in GMV in this area was 17.6%. No other area showing decreased GMV was found to have a corrected cluster probability value approaching significance.


Anorexia Nervosa during Adolescence Is Associated with Decreased Gray Matter Volume in the Inferior Frontal Gyrus.

Fujisawa TX, Yatsuga C, Mabe H, Yamada E, Masuda M, Tomoda A - PLoS ONE (2015)

Voxel based morphometry results.Locations displaying significant differences between AN and control participants in regional GMV. Significantly lower GM densities among AN participants were revealed in the bilateral IFG (Brodmann area 45/46). Color scale: 0–5 represents t-values.
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4465897&req=5

pone.0128548.g001: Voxel based morphometry results.Locations displaying significant differences between AN and control participants in regional GMV. Significantly lower GM densities among AN participants were revealed in the bilateral IFG (Brodmann area 45/46). Color scale: 0–5 represents t-values.
Mentions: After correcting for age and tGMV, regional GMV decreases in the bilateral inferior frontal gyrus (IFG) were observed among AN participants (Table 2). An analysis of region-specific GM changes (ANCOVA with age and total GMV as control variables) yielded two clusters in the bilateral IFG (Fig 1; Table 3). The most prominent neural finding was a significant decrease in GMV in the left IFG in patients with AN (Brodmann area 45/46 [BA45/46]; Talairach’s coordinates x = -52, y = 30, z = 24, Z = 4.40, k = 434 voxels; p < .001 for height, FWE corrected to p < .05 for multiple comparisons). The mean decrease in GMV in this area was 19.1% among AN patients. Similarly, significant decreases in GMV in the right IFG were observed in the AN group (BA45/46; Talairach’s coordinates x = 58, y = 30, z = 20, Z = 4.04, cluster size = 225 voxels; p < .001 for height, corrected to p < .05 for multiple comparisons using cluster size). The mean decrease in GMV in this area was 17.6%. No other area showing decreased GMV was found to have a corrected cluster probability value approaching significance.

Bottom Line: The GMV in the bilateral IFG correlated significantly with current age (left IFG: r = -.481, p < .05; right IFG: r = -.601, p < .01) and was limited to the AN group.We speculate that decreased IFG volume might lead to deficits in executive functioning or inhibitory control within neural reward systems.Precocious or unbalanced neurological trimming within this particular region might be an important factor for the pathogenesis of AN onset.

View Article: PubMed Central - PubMed

Affiliation: Research Center for Child Mental Development, University of Fukui, Fukui, Japan; Department of Child Development, United Graduate School of Child Development, Osaka University, Kanazawa University, Hamamatsu University School of Medicine, Chiba University and University of Fukui, Fukui, Japan.

ABSTRACT
Anorexia nervosa (AN) is an eating disorder characterized by the relentless pursuit to lose weight, mostly through self-starvation, and a distorted body image. AN tends to begin during adolescence among women. However, the underlying neural mechanisms related to AN remain unclear. Using voxel-based morphometry based on magnetic resonance imaging scans, we investigated whether the presence of AN was associated with discernible changes in brain morphology. Participants were 20 un-medicated, right-handed patients with early-onset AN and 14 healthy control subjects. Group differences in gray matter volume (GMV) were assessed using high-resolution, T1-weighted, volumetric magnetic resonance imaging datasets (3T Trio scanner; Siemens AG) and analyzed after controlling for age and total GMV, which was decreased in the bilateral inferior frontal gyrus (IFG) (left IFG: FWE corrected, p < 0.05; right IFG: uncorrected, p < 0.05) of patients with AN. The GMV in the bilateral IFG correlated significantly with current age (left IFG: r = -.481, p < .05; right IFG: r = -.601, p < .01) and was limited to the AN group. We speculate that decreased IFG volume might lead to deficits in executive functioning or inhibitory control within neural reward systems. Precocious or unbalanced neurological trimming within this particular region might be an important factor for the pathogenesis of AN onset.

No MeSH data available.


Related in: MedlinePlus