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Therapeutic Touch Has Significant Effects on Mouse Breast Cancer Metastasis and Immune Responses but Not Primary Tumor Size.

Gronowicz G, Secor ER, Flynn JR, Jellison ER, Kuhn LT - Evid Based Complement Alternat Med (2015)

Bottom Line: No significant differences were found in body weight gain or tumor size.Metastasis was significantly reduced in the TT-treated mice compared to mock-treated mice.TT significantly reduced IL-1-a, MIG, IL-1b, and MIP-2 to control/vehicle levels.

View Article: PubMed Central - PubMed

Affiliation: Department of Surgery, University of Connecticut Health Center, Farmington, CT 06030, USA.

ABSTRACT
Evidence-based integrative medicine therapies have been introduced to promote wellness and offset side-effects from cancer treatment. Energy medicine is an integrative medicine technique using the human biofield to promote well-being. The biofield therapy chosen for study was Therapeutic Touch (TT). Breast cancer tumors were initiated in mice by injection of metastatic 66cl4 mammary carcinoma cells. The control group received only vehicle. TT or mock treatments were performed twice a week for 10 minutes. Two experienced TT practitioners alternated treatments. At 26 days, metastasis to popliteal lymph nodes was determined by clonogenic assay. Changes in immune function were measured by analysis of serum cytokines and by fluorescent activated cells sorting (FACS) of immune cells from the spleen and lymph nodes. No significant differences were found in body weight gain or tumor size. Metastasis was significantly reduced in the TT-treated mice compared to mock-treated mice. Cancer significantly elevated eleven cytokines. TT significantly reduced IL-1-a, MIG, IL-1b, and MIP-2 to control/vehicle levels. FACS demonstrated that TT significantly reduced specific splenic lymphocyte subsets and macrophages were significantly elevated with cancer. Human biofield therapy had no significant effect on primary tumor but produced significant effects on metastasis and immune responses in a mouse breast cancer model.

No MeSH data available.


Related in: MedlinePlus

Effect of human biofield on serum cytokine/chemokine levels. Human biofield treatment (TT) significantly decreased IL-1α, IL-1β, MIG, and MIP-2 from their high levels in the mock treatment group (CA) to the levels found in the control group (PBS). Bars are means ± standard error of the means. N = 8 mice per group.
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fig3: Effect of human biofield on serum cytokine/chemokine levels. Human biofield treatment (TT) significantly decreased IL-1α, IL-1β, MIG, and MIP-2 from their high levels in the mock treatment group (CA) to the levels found in the control group (PBS). Bars are means ± standard error of the means. N = 8 mice per group.

Mentions: With human biofield treatment (TT), 4 of 11 cytokines significantly decreased to control levels compared to the serum from mice that were mock-treated (CA). IL-1β, IL-1α, MIP-2, and MIG were upregulated by cancer and downregulated to control levels (PBS-treated mice) by TT (Figure 3).


Therapeutic Touch Has Significant Effects on Mouse Breast Cancer Metastasis and Immune Responses but Not Primary Tumor Size.

Gronowicz G, Secor ER, Flynn JR, Jellison ER, Kuhn LT - Evid Based Complement Alternat Med (2015)

Effect of human biofield on serum cytokine/chemokine levels. Human biofield treatment (TT) significantly decreased IL-1α, IL-1β, MIG, and MIP-2 from their high levels in the mock treatment group (CA) to the levels found in the control group (PBS). Bars are means ± standard error of the means. N = 8 mice per group.
© Copyright Policy - open-access
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC4465772&req=5

fig3: Effect of human biofield on serum cytokine/chemokine levels. Human biofield treatment (TT) significantly decreased IL-1α, IL-1β, MIG, and MIP-2 from their high levels in the mock treatment group (CA) to the levels found in the control group (PBS). Bars are means ± standard error of the means. N = 8 mice per group.
Mentions: With human biofield treatment (TT), 4 of 11 cytokines significantly decreased to control levels compared to the serum from mice that were mock-treated (CA). IL-1β, IL-1α, MIP-2, and MIG were upregulated by cancer and downregulated to control levels (PBS-treated mice) by TT (Figure 3).

Bottom Line: No significant differences were found in body weight gain or tumor size.Metastasis was significantly reduced in the TT-treated mice compared to mock-treated mice.TT significantly reduced IL-1-a, MIG, IL-1b, and MIP-2 to control/vehicle levels.

View Article: PubMed Central - PubMed

Affiliation: Department of Surgery, University of Connecticut Health Center, Farmington, CT 06030, USA.

ABSTRACT
Evidence-based integrative medicine therapies have been introduced to promote wellness and offset side-effects from cancer treatment. Energy medicine is an integrative medicine technique using the human biofield to promote well-being. The biofield therapy chosen for study was Therapeutic Touch (TT). Breast cancer tumors were initiated in mice by injection of metastatic 66cl4 mammary carcinoma cells. The control group received only vehicle. TT or mock treatments were performed twice a week for 10 minutes. Two experienced TT practitioners alternated treatments. At 26 days, metastasis to popliteal lymph nodes was determined by clonogenic assay. Changes in immune function were measured by analysis of serum cytokines and by fluorescent activated cells sorting (FACS) of immune cells from the spleen and lymph nodes. No significant differences were found in body weight gain or tumor size. Metastasis was significantly reduced in the TT-treated mice compared to mock-treated mice. Cancer significantly elevated eleven cytokines. TT significantly reduced IL-1-a, MIG, IL-1b, and MIP-2 to control/vehicle levels. FACS demonstrated that TT significantly reduced specific splenic lymphocyte subsets and macrophages were significantly elevated with cancer. Human biofield therapy had no significant effect on primary tumor but produced significant effects on metastasis and immune responses in a mouse breast cancer model.

No MeSH data available.


Related in: MedlinePlus