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Diabetes Remission after Nonsurgical Intensive Lifestyle Intervention in Obese Patients with Type 2 Diabetes.

Mottalib A, Sakr M, Shehabeldin M, Hamdy O - J Diabetes Res (2015)

Bottom Line: Among 120 obese patients with type 2 diabetes who completed the program, 88 patients returned for follow-up at one year.They achieved a weight reduction of >7% after 12 weeks.These results indicate that a subset of obese patients with type 2 diabetes is appropriate for intensive lifestyle intervention with the aim of inducing diabetes remission.

View Article: PubMed Central - PubMed

Affiliation: Joslin Diabetes Center, One Joslin Place, Boston, MA 02215, USA.

ABSTRACT
Partial or complete remission from type 2 diabetes was recently observed after bariatric surgeries. Limited data is available about the possibility of inducing diabetes remission through intensive weight reduction. We retrospectively evaluated diabetes remissions after one year of the Weight Achievement and Intensive Treatment (Why WAIT) program, a 12-week intensive program for diabetes weight management in real-world clinical practice. Among 120 obese patients with type 2 diabetes who completed the program, 88 patients returned for follow-up at one year. Nineteen patients (21.6%) had major improvement in their glycemic control, defined as achieving an A1C <6.5% after one year. Four patients (4.5%) achieved either partial or complete diabetes remission defined as A1C <6.5% and <5.7%, respectively, on no antihyperglycemic medications for one year; 2 achieved partial remission (2.3%) and 2 achieved complete remission (2.3%). At the time of intervention, patients who achieved diabetes remission had shorter diabetes duration (<5 years) and lower A1C (<8%) and were treated with fewer than 2 oral medications. They achieved a weight reduction of >7% after 12 weeks. These results indicate that a subset of obese patients with type 2 diabetes is appropriate for intensive lifestyle intervention with the aim of inducing diabetes remission.

No MeSH data available.


Related in: MedlinePlus

Flow of study participants.
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fig1: Flow of study participants.

Mentions: A total of 126 obese patients with type 2 diabetes were enrolled in the Why WAIT program during the study period. Six of them dropped out during the program for personal reasons. Out of the remaining 120 patients, 88 patients completed one year of follow-up (Figure 1). Nineteen participants (21.6%) had major improvement of glycemic control, 4 participants (4.6%) achieved either partial or complete diabetes remission, 2 achieved partial remission (2.3%), and 2 achieved complete remission (2.3%) (Figure 2).


Diabetes Remission after Nonsurgical Intensive Lifestyle Intervention in Obese Patients with Type 2 Diabetes.

Mottalib A, Sakr M, Shehabeldin M, Hamdy O - J Diabetes Res (2015)

Flow of study participants.
© Copyright Policy - open-access
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC4465710&req=5

fig1: Flow of study participants.
Mentions: A total of 126 obese patients with type 2 diabetes were enrolled in the Why WAIT program during the study period. Six of them dropped out during the program for personal reasons. Out of the remaining 120 patients, 88 patients completed one year of follow-up (Figure 1). Nineteen participants (21.6%) had major improvement of glycemic control, 4 participants (4.6%) achieved either partial or complete diabetes remission, 2 achieved partial remission (2.3%), and 2 achieved complete remission (2.3%) (Figure 2).

Bottom Line: Among 120 obese patients with type 2 diabetes who completed the program, 88 patients returned for follow-up at one year.They achieved a weight reduction of >7% after 12 weeks.These results indicate that a subset of obese patients with type 2 diabetes is appropriate for intensive lifestyle intervention with the aim of inducing diabetes remission.

View Article: PubMed Central - PubMed

Affiliation: Joslin Diabetes Center, One Joslin Place, Boston, MA 02215, USA.

ABSTRACT
Partial or complete remission from type 2 diabetes was recently observed after bariatric surgeries. Limited data is available about the possibility of inducing diabetes remission through intensive weight reduction. We retrospectively evaluated diabetes remissions after one year of the Weight Achievement and Intensive Treatment (Why WAIT) program, a 12-week intensive program for diabetes weight management in real-world clinical practice. Among 120 obese patients with type 2 diabetes who completed the program, 88 patients returned for follow-up at one year. Nineteen patients (21.6%) had major improvement in their glycemic control, defined as achieving an A1C <6.5% after one year. Four patients (4.5%) achieved either partial or complete diabetes remission defined as A1C <6.5% and <5.7%, respectively, on no antihyperglycemic medications for one year; 2 achieved partial remission (2.3%) and 2 achieved complete remission (2.3%). At the time of intervention, patients who achieved diabetes remission had shorter diabetes duration (<5 years) and lower A1C (<8%) and were treated with fewer than 2 oral medications. They achieved a weight reduction of >7% after 12 weeks. These results indicate that a subset of obese patients with type 2 diabetes is appropriate for intensive lifestyle intervention with the aim of inducing diabetes remission.

No MeSH data available.


Related in: MedlinePlus