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Evidence for a Shared Etiological Mechanism of Psychotic Symptoms and Obsessive-Compulsive Symptoms in Patients with Psychotic Disorders and Their Siblings.

Swets M, Van Dael F, Roza S, Schoevers R, Myin-Germeys I, de Haan L, Genetic Risk and Outcome of Psychosis (GROUP) investigato - PLoS ONE (2015)

Bottom Line: However, little is known about the origins of their elevated co-occurrence.Second, in a cross-sib cross-trait analysis, it was examined whether (subclinical) obsessive-compulsive symptoms in the patient were associated with (subclinical) psychotic symptoms in the related unaffected sibling.This is the first study that used a cross-sib cross-trait design in patients and unaffected siblings, thus circumventing confounding by disease-related factors present in clinical samples.

View Article: PubMed Central - PubMed

Affiliation: Arkin Mental Health and Addiction Treatment Centre, Amsterdam, the Netherlands.

ABSTRACT
The prevalence of obsessive-compulsive disorder in subjects with psychotic disorder is much higher than in the general population. The higher than chance co-occurrence has also been demonstrated at the level of subclinical expression of both phenotypes. Both extended phenotypes have been shown to cluster in families. However, little is known about the origins of their elevated co-occurrence. In the present study, evidence for a shared etiological mechanism was investigated in 3 samples with decreasing levels of familial psychosis liability: 987 patients, 973 of their unaffected siblings and 566 healthy controls. The association between the obsessive-compulsive phenotype and the psychosis phenotype c.q. psychosis liability was investigated. First, the association was assessed between (subclinical) obsessive-compulsive symptoms and psychosis liability. Second, in a cross-sib cross-trait analysis, it was examined whether (subclinical) obsessive-compulsive symptoms in the patient were associated with (subclinical) psychotic symptoms in the related unaffected sibling. Evidence was found for both associations, which is compatible with a partially shared etiological pathway underlying obsessive-compulsive and psychotic disorder. This is the first study that used a cross-sib cross-trait design in patients and unaffected siblings, thus circumventing confounding by disease-related factors present in clinical samples.

No MeSH data available.


Related in: MedlinePlus

Prevalence of OCS in function of 3-level psychosis liability (status).Clinical OCS: YBOCS>9. Broad OCS: YBOCS>0. * Differences in prevalence between distinct psychosis liability groups are all significant.
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pone.0125103.g002: Prevalence of OCS in function of 3-level psychosis liability (status).Clinical OCS: YBOCS>9. Broad OCS: YBOCS>0. * Differences in prevalence between distinct psychosis liability groups are all significant.

Mentions: Clinically relevant OCS (Y-BOCS >9) were significantly more prevalent in patients (19.0%, n = 188) (OR = 18.4, 95% CI:8.8–38.7, p<0.000) and siblings (4.3%, n = 42) (OR = 2.9, 95% CI:1.4–6.2, p<0.006) compared to controls (1.6%, n = 9). Patients reported significantly more clinically relevant OCS compared to siblings (χ2(1) = 80.6,p<0.00005). The associations remained significant after adjusting for confounders (Fig 2).


Evidence for a Shared Etiological Mechanism of Psychotic Symptoms and Obsessive-Compulsive Symptoms in Patients with Psychotic Disorders and Their Siblings.

Swets M, Van Dael F, Roza S, Schoevers R, Myin-Germeys I, de Haan L, Genetic Risk and Outcome of Psychosis (GROUP) investigato - PLoS ONE (2015)

Prevalence of OCS in function of 3-level psychosis liability (status).Clinical OCS: YBOCS>9. Broad OCS: YBOCS>0. * Differences in prevalence between distinct psychosis liability groups are all significant.
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4465647&req=5

pone.0125103.g002: Prevalence of OCS in function of 3-level psychosis liability (status).Clinical OCS: YBOCS>9. Broad OCS: YBOCS>0. * Differences in prevalence between distinct psychosis liability groups are all significant.
Mentions: Clinically relevant OCS (Y-BOCS >9) were significantly more prevalent in patients (19.0%, n = 188) (OR = 18.4, 95% CI:8.8–38.7, p<0.000) and siblings (4.3%, n = 42) (OR = 2.9, 95% CI:1.4–6.2, p<0.006) compared to controls (1.6%, n = 9). Patients reported significantly more clinically relevant OCS compared to siblings (χ2(1) = 80.6,p<0.00005). The associations remained significant after adjusting for confounders (Fig 2).

Bottom Line: However, little is known about the origins of their elevated co-occurrence.Second, in a cross-sib cross-trait analysis, it was examined whether (subclinical) obsessive-compulsive symptoms in the patient were associated with (subclinical) psychotic symptoms in the related unaffected sibling.This is the first study that used a cross-sib cross-trait design in patients and unaffected siblings, thus circumventing confounding by disease-related factors present in clinical samples.

View Article: PubMed Central - PubMed

Affiliation: Arkin Mental Health and Addiction Treatment Centre, Amsterdam, the Netherlands.

ABSTRACT
The prevalence of obsessive-compulsive disorder in subjects with psychotic disorder is much higher than in the general population. The higher than chance co-occurrence has also been demonstrated at the level of subclinical expression of both phenotypes. Both extended phenotypes have been shown to cluster in families. However, little is known about the origins of their elevated co-occurrence. In the present study, evidence for a shared etiological mechanism was investigated in 3 samples with decreasing levels of familial psychosis liability: 987 patients, 973 of their unaffected siblings and 566 healthy controls. The association between the obsessive-compulsive phenotype and the psychosis phenotype c.q. psychosis liability was investigated. First, the association was assessed between (subclinical) obsessive-compulsive symptoms and psychosis liability. Second, in a cross-sib cross-trait analysis, it was examined whether (subclinical) obsessive-compulsive symptoms in the patient were associated with (subclinical) psychotic symptoms in the related unaffected sibling. Evidence was found for both associations, which is compatible with a partially shared etiological pathway underlying obsessive-compulsive and psychotic disorder. This is the first study that used a cross-sib cross-trait design in patients and unaffected siblings, thus circumventing confounding by disease-related factors present in clinical samples.

No MeSH data available.


Related in: MedlinePlus