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Why Social Pain Can Live on: Different Neural Mechanisms Are Associated with Reliving Social and Physical Pain.

Meyer ML, Williams KD, Eisenberger NI - PLoS ONE (2015)

Bottom Line: In contrast, reliving physical (vs. social) pain led to greater activity in the sensory-discriminative pain system (primary and secondary somatosensory cortex and posterior insula), which did not correlate with relived pain.Social pain reliving recruited dorsomedial prefrontal cortex, often associated with mental state processing, which functionally correlated with affective pain system responses.These results update the physical-social pain overlap hypothesis: while overlapping mechanisms support live social and physical pain, distinct mechanisms guide internally-generated pain.

View Article: PubMed Central - PubMed

Affiliation: Psychology Department, University of California Los Angeles, Los Angeles, California, United States of America.

ABSTRACT
Although social and physical pain recruit overlapping neural activity in regions associated with the affective component of pain, the two pains can diverge in their phenomenology. Most notably, feelings of social pain can be re-experienced or "relived," even when the painful episode has long passed, whereas feelings of physical pain cannot be easily relived once the painful episode subsides. Here, we observed that reliving social (vs. physical) pain led to greater self-reported re-experienced pain and greater activity in affective pain regions (dorsal anterior cingulate cortex and anterior insula). Moreover, the degree of relived pain correlated positively with affective pain system activity. In contrast, reliving physical (vs. social) pain led to greater activity in the sensory-discriminative pain system (primary and secondary somatosensory cortex and posterior insula), which did not correlate with relived pain. Preferential engagement of these different pain mechanisms may reflect the use of different top-down neurocognitive pathways to elicit the pain. Social pain reliving recruited dorsomedial prefrontal cortex, often associated with mental state processing, which functionally correlated with affective pain system responses. In contrast, physical pain reliving recruited inferior frontal gyrus, known to be involved in body state processing, which functionally correlated with activation in the sensory pain system. These results update the physical-social pain overlap hypothesis: while overlapping mechanisms support live social and physical pain, distinct mechanisms guide internally-generated pain.

No MeSH data available.


Related in: MedlinePlus

Interaction of reliving social pain vs. social neutral, relative to reliving physical pain vs. physical neutral.
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pone.0128294.g003: Interaction of reliving social pain vs. social neutral, relative to reliving physical pain vs. physical neutral.

Mentions: We hypothesized that this greater capacity to re-experience social pain may occur, in part, because individuals recruit greater affective pain system activity while reliving social pain than while reliving physical pain. Consistent with this prediction, the interaction contrast comparing neural activation during social pain reliving vs. social neutral reliving, relative to physical pain reliving vs. physical neutral reliving (i.e., (social pain reliving>social neutral reliving)>(physical pain reliving>physical neutral reliving)), revealed neural activation in affective pain regions (dACC, AI, Fig 3, Table 1) but no sensory pain region activity. This interaction contrast is a highly specific contrast, as it partials out any activity during social and physical pain reliving that might be tied to the content of the pain type (that is, cognition related to social versus physical processing). Post-hoc analyses of the interaction revealed greater activity in the dACC and AI clusters during social pain reliving relative to social neutral reliving (ps <.001), but no differences in activity during physical pain reliving relative to physical neutral reliving (ps >.14). Importantly, there was also greater activity in the dACC and AI during social pain reliving relative to physical pain reliving (ps<.05).


Why Social Pain Can Live on: Different Neural Mechanisms Are Associated with Reliving Social and Physical Pain.

Meyer ML, Williams KD, Eisenberger NI - PLoS ONE (2015)

Interaction of reliving social pain vs. social neutral, relative to reliving physical pain vs. physical neutral.
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4465485&req=5

pone.0128294.g003: Interaction of reliving social pain vs. social neutral, relative to reliving physical pain vs. physical neutral.
Mentions: We hypothesized that this greater capacity to re-experience social pain may occur, in part, because individuals recruit greater affective pain system activity while reliving social pain than while reliving physical pain. Consistent with this prediction, the interaction contrast comparing neural activation during social pain reliving vs. social neutral reliving, relative to physical pain reliving vs. physical neutral reliving (i.e., (social pain reliving>social neutral reliving)>(physical pain reliving>physical neutral reliving)), revealed neural activation in affective pain regions (dACC, AI, Fig 3, Table 1) but no sensory pain region activity. This interaction contrast is a highly specific contrast, as it partials out any activity during social and physical pain reliving that might be tied to the content of the pain type (that is, cognition related to social versus physical processing). Post-hoc analyses of the interaction revealed greater activity in the dACC and AI clusters during social pain reliving relative to social neutral reliving (ps <.001), but no differences in activity during physical pain reliving relative to physical neutral reliving (ps >.14). Importantly, there was also greater activity in the dACC and AI during social pain reliving relative to physical pain reliving (ps<.05).

Bottom Line: In contrast, reliving physical (vs. social) pain led to greater activity in the sensory-discriminative pain system (primary and secondary somatosensory cortex and posterior insula), which did not correlate with relived pain.Social pain reliving recruited dorsomedial prefrontal cortex, often associated with mental state processing, which functionally correlated with affective pain system responses.These results update the physical-social pain overlap hypothesis: while overlapping mechanisms support live social and physical pain, distinct mechanisms guide internally-generated pain.

View Article: PubMed Central - PubMed

Affiliation: Psychology Department, University of California Los Angeles, Los Angeles, California, United States of America.

ABSTRACT
Although social and physical pain recruit overlapping neural activity in regions associated with the affective component of pain, the two pains can diverge in their phenomenology. Most notably, feelings of social pain can be re-experienced or "relived," even when the painful episode has long passed, whereas feelings of physical pain cannot be easily relived once the painful episode subsides. Here, we observed that reliving social (vs. physical) pain led to greater self-reported re-experienced pain and greater activity in affective pain regions (dorsal anterior cingulate cortex and anterior insula). Moreover, the degree of relived pain correlated positively with affective pain system activity. In contrast, reliving physical (vs. social) pain led to greater activity in the sensory-discriminative pain system (primary and secondary somatosensory cortex and posterior insula), which did not correlate with relived pain. Preferential engagement of these different pain mechanisms may reflect the use of different top-down neurocognitive pathways to elicit the pain. Social pain reliving recruited dorsomedial prefrontal cortex, often associated with mental state processing, which functionally correlated with affective pain system responses. In contrast, physical pain reliving recruited inferior frontal gyrus, known to be involved in body state processing, which functionally correlated with activation in the sensory pain system. These results update the physical-social pain overlap hypothesis: while overlapping mechanisms support live social and physical pain, distinct mechanisms guide internally-generated pain.

No MeSH data available.


Related in: MedlinePlus