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Emotion Reactivity Is Increased 4-6 Weeks Postpartum in Healthy Women: A Longitudinal fMRI Study.

Gingnell M, Bannbers E, Moes H, Engman J, Sylvén S, Skalkidou A, Kask K, Wikström J, Sundström-Poromaa I - PLoS ONE (2015)

Bottom Line: Most women cope well with these changes, but the postpartum period is associated with an increased risk of depressive episodes.Reactivity in insula and IFG were greater in postpartum women than in non-pregnant control subjects.These findings contribute to our understanding of the neurobiological aspects of the postpartum period, which might shed light on the mechanisms underlying affective puerperal disorders, such as PPD.

View Article: PubMed Central - PubMed

Affiliation: Department of Women's and Children's Health, Uppsala University, Uppsala, Sweden; Department of Psychology, Uppsala University, Uppsala, Sweden.

ABSTRACT
Marked endocrine alterations occur after delivery. Most women cope well with these changes, but the postpartum period is associated with an increased risk of depressive episodes. Previous studies of emotion processing have focused on maternal-infant bonding or postpartum depression (PPD), and longitudinal studies of the neural correlates of emotion processing throughout the postpartum period in healthy women are lacking. In this study, 13 women, without signs of post partum depression, underwent fMRI with an emotional face matching task and completed the MADRS-S, STAI-S, and EPDS within 48 h (early postpartum) and 4-6 weeks after delivery (late postpartum). Also, data from a previous study including 15 naturally cycling controls assessed in the luteal and follicular phase of the menstrual cycle was used. Women had lower reactivity in insula, middle frontal gyrus (MFG), and inferior frontal gyrus (IFG) in the early as compared to the late postpartum assessment. Insular reactivity was positively correlated with anxiety in the early postpartum period and with depressive symptoms late postpartum. Reactivity in insula and IFG were greater in postpartum women than in non-pregnant control subjects. Brain reactivity was not correlated with serum estradiol or progesterone levels. Increased reactivity in the insula, IFG, and MFG may reflect normal postpartum adaptation, but correlation with self-rated symptoms of depression and anxiety in these otherwise healthy postpartum women, may also suggest that these changes place susceptible women at increased risk of PPD. These findings contribute to our understanding of the neurobiological aspects of the postpartum period, which might shed light on the mechanisms underlying affective puerperal disorders, such as PPD.

No MeSH data available.


Related in: MedlinePlus

Reactivity in the right inferior frontal gyrus (A, B), left middle frontal gyrus (C) and right insula (D) during emotional stimulation was more pronounced in late postpartum than in early postpartum in 13 healthy newly delivered women.Brighter colors indicate higher T-scores. Early postpartum assessment was made within 48 hours of delivery, and late postpartum assessment within 4–6 weeks from delivery.
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pone.0128964.g001: Reactivity in the right inferior frontal gyrus (A, B), left middle frontal gyrus (C) and right insula (D) during emotional stimulation was more pronounced in late postpartum than in early postpartum in 13 healthy newly delivered women.Brighter colors indicate higher T-scores. Early postpartum assessment was made within 48 hours of delivery, and late postpartum assessment within 4–6 weeks from delivery.

Mentions: Reactivity in the right insula, bilateral IFG and left MFG was lower in the early than in the late postpartum assessment (Table 3, Fig 1). At the early postpartum assessment reactivity in the IFG (BA 9) and the insula was positively correlated with state anxiety. At the late postpartum assessment reactivity in the IFG (BA 44 and 9) and the insula was positively correlated with self-rated depression, as assessed with the MADRS-S, and for insula also with a trend for the EPDS (Table 4, Fig 2). No correlation between brain reactivity and estradiol or progesterone serum concentration was observed at any of the postpartum time-points (S1 Table). There were no regions where reactivity was higher at the early postpartum than late post partum.


Emotion Reactivity Is Increased 4-6 Weeks Postpartum in Healthy Women: A Longitudinal fMRI Study.

Gingnell M, Bannbers E, Moes H, Engman J, Sylvén S, Skalkidou A, Kask K, Wikström J, Sundström-Poromaa I - PLoS ONE (2015)

Reactivity in the right inferior frontal gyrus (A, B), left middle frontal gyrus (C) and right insula (D) during emotional stimulation was more pronounced in late postpartum than in early postpartum in 13 healthy newly delivered women.Brighter colors indicate higher T-scores. Early postpartum assessment was made within 48 hours of delivery, and late postpartum assessment within 4–6 weeks from delivery.
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4465482&req=5

pone.0128964.g001: Reactivity in the right inferior frontal gyrus (A, B), left middle frontal gyrus (C) and right insula (D) during emotional stimulation was more pronounced in late postpartum than in early postpartum in 13 healthy newly delivered women.Brighter colors indicate higher T-scores. Early postpartum assessment was made within 48 hours of delivery, and late postpartum assessment within 4–6 weeks from delivery.
Mentions: Reactivity in the right insula, bilateral IFG and left MFG was lower in the early than in the late postpartum assessment (Table 3, Fig 1). At the early postpartum assessment reactivity in the IFG (BA 9) and the insula was positively correlated with state anxiety. At the late postpartum assessment reactivity in the IFG (BA 44 and 9) and the insula was positively correlated with self-rated depression, as assessed with the MADRS-S, and for insula also with a trend for the EPDS (Table 4, Fig 2). No correlation between brain reactivity and estradiol or progesterone serum concentration was observed at any of the postpartum time-points (S1 Table). There were no regions where reactivity was higher at the early postpartum than late post partum.

Bottom Line: Most women cope well with these changes, but the postpartum period is associated with an increased risk of depressive episodes.Reactivity in insula and IFG were greater in postpartum women than in non-pregnant control subjects.These findings contribute to our understanding of the neurobiological aspects of the postpartum period, which might shed light on the mechanisms underlying affective puerperal disorders, such as PPD.

View Article: PubMed Central - PubMed

Affiliation: Department of Women's and Children's Health, Uppsala University, Uppsala, Sweden; Department of Psychology, Uppsala University, Uppsala, Sweden.

ABSTRACT
Marked endocrine alterations occur after delivery. Most women cope well with these changes, but the postpartum period is associated with an increased risk of depressive episodes. Previous studies of emotion processing have focused on maternal-infant bonding or postpartum depression (PPD), and longitudinal studies of the neural correlates of emotion processing throughout the postpartum period in healthy women are lacking. In this study, 13 women, without signs of post partum depression, underwent fMRI with an emotional face matching task and completed the MADRS-S, STAI-S, and EPDS within 48 h (early postpartum) and 4-6 weeks after delivery (late postpartum). Also, data from a previous study including 15 naturally cycling controls assessed in the luteal and follicular phase of the menstrual cycle was used. Women had lower reactivity in insula, middle frontal gyrus (MFG), and inferior frontal gyrus (IFG) in the early as compared to the late postpartum assessment. Insular reactivity was positively correlated with anxiety in the early postpartum period and with depressive symptoms late postpartum. Reactivity in insula and IFG were greater in postpartum women than in non-pregnant control subjects. Brain reactivity was not correlated with serum estradiol or progesterone levels. Increased reactivity in the insula, IFG, and MFG may reflect normal postpartum adaptation, but correlation with self-rated symptoms of depression and anxiety in these otherwise healthy postpartum women, may also suggest that these changes place susceptible women at increased risk of PPD. These findings contribute to our understanding of the neurobiological aspects of the postpartum period, which might shed light on the mechanisms underlying affective puerperal disorders, such as PPD.

No MeSH data available.


Related in: MedlinePlus