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Impact of motion correction on reproducibility and spatial variability of quantitative myocardial T2 mapping.

Roujol S, Basha TA, Weingärtner S, Akçakaya M, Berg S, Manning WJ, Nezafat R - J Cardiovasc Magn Reson (2015)

Bottom Line: In-plane myocardial motion was corrected using an adaptive registration of varying contrast-weighted images for improved tissue characterization (ARCTIC).ARCTIC led to increased DSC in BH data (0.85 ± 0.08 vs. 0.90 ± 0.02, p = 0.007), FB data (0.78 ± 0.13 vs. 0.90 ± 0.21, p < 0.001), and FB + NAV data (0.86 ± 0.05 vs. 0.90 ± 0.02, p = 0.002), and reduced MBE in BH data (0.90 ± 0.40 vs. 0.64 ± 0.19 mm, p = 0.005), FB data (1.21 ± 0.65 vs. 0.63 ± 0.10 mm, p < 0.001), and FB + NAV data (0.81 ± 0.21 vs. 0.63 ± 0.08 mm, p < 0.001).The ARCTIC technique substantially reduces spatial mis-alignment among T2-weighted images and improves the reproducibility and spatial variability of in-vivo T2 mapping.

View Article: PubMed Central - PubMed

Affiliation: Department of Medicine (Cardiovascular Division), Beth Israel Deaconess Medical Center, 330 Brookline Ave, Boston, MA, 02215, USA. sroujol@bidmc.harvard.edu.

ABSTRACT

Background: To evaluate and quantify the impact of a novel image-based motion correction technique in myocardial T2 mapping in terms of measurement reproducibility and spatial variability.

Methods: Twelve healthy adult subjects were imaged using breath-hold (BH), free breathing (FB), and free breathing with respiratory navigator gating (FB + NAV) myocardial T2 mapping sequences. Fifty patients referred for clinical CMR were imaged using the FB + NAV sequence. All sequences used a T2 prepared (T2prep) steady-state free precession acquisition. In-plane myocardial motion was corrected using an adaptive registration of varying contrast-weighted images for improved tissue characterization (ARCTIC). DICE similarity coefficient (DSC) and myocardial boundary errors (MBE) were measured to quantify the motion estimation accuracy in healthy subjects. T2 mapping reproducibility and spatial variability were evaluated in healthy subjects using 5 repetitions of the FB + NAV sequence with either 4 or 20 T2prep echo times (TE). Subjective T2 map quality was assessed in patients by an experienced reader using a 4-point scale (1-non diagnostic, 4-excellent).

Results: ARCTIC led to increased DSC in BH data (0.85 ± 0.08 vs. 0.90 ± 0.02, p = 0.007), FB data (0.78 ± 0.13 vs. 0.90 ± 0.21, p < 0.001), and FB + NAV data (0.86 ± 0.05 vs. 0.90 ± 0.02, p = 0.002), and reduced MBE in BH data (0.90 ± 0.40 vs. 0.64 ± 0.19 mm, p = 0.005), FB data (1.21 ± 0.65 vs. 0.63 ± 0.10 mm, p < 0.001), and FB + NAV data (0.81 ± 0.21 vs. 0.63 ± 0.08 mm, p < 0.001). Improved reproducibility (4TE: 5.3 ± 2.5 ms vs. 4.0 ± 1.5 ms, p = 0.016; 20TE: 3.9 ± 2.3 ms vs. 2.2 ± 0.5 ms, p = 0.002), reduced spatial variability (4TE: 12.8 ± 3.5 ms vs. 10.3 ± 2.5 ms, p < 0.001; 20TE: 9.7 ± 3.5 ms vs. 7.5 ± 1.4 ms) and improved subjective score of T2 map quality (3.43 ± 0.79 vs. 3.69 ± 0.55, p < 0.001) were obtained using ARCTIC.

Conclusions: The ARCTIC technique substantially reduces spatial mis-alignment among T2-weighted images and improves the reproducibility and spatial variability of in-vivo T2 mapping.

No MeSH data available.


Related in: MedlinePlus

Spatial variability of T2 mapping in all subjects using the T2P20TE sequence acquired under free breathing conditions with respiratory navigator gating. Spatial variability was evaluated for T2 maps reconstructed using only a subset of the T2prep echo times (0 ms, 25 ms, 50 ms, ∞) (4TEs) (a,b) and using all 20 T2prep echo times (20 TEs) (c,d). Average and standard deviation of T2 spatial variability is reported over all subjects for each segment (a,c) and over all segments for each subject (b,d). In-plane motion correction using ARCTIC reduced the spatial variability of T2 mapping
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Fig5: Spatial variability of T2 mapping in all subjects using the T2P20TE sequence acquired under free breathing conditions with respiratory navigator gating. Spatial variability was evaluated for T2 maps reconstructed using only a subset of the T2prep echo times (0 ms, 25 ms, 50 ms, ∞) (4TEs) (a,b) and using all 20 T2prep echo times (20 TEs) (c,d). Average and standard deviation of T2 spatial variability is reported over all subjects for each segment (a,c) and over all segments for each subject (b,d). In-plane motion correction using ARCTIC reduced the spatial variability of T2 mapping

Mentions: Figures 4 and 5 summarize the reproducibility and spatial variability of T2 measurements obtained in healthy subjects using the T2P20TE sequence. Results are shown for uncorrected and motion corrected T2 maps reconstructed using either 4 T2prep echo times or 20 T2prep echo times. Reproducibility and spatial variability are reported as uncorrected T2 maps vs. motion corrected T2 maps using ARCTIC. Improved reproducibility was observed over all subjects and myocardial segments in T2 maps reconstructed from 4 T2prep echo times (5.3 ± 2.5 ms vs. 4.0 ± 1.5 ms, p = 0.016) and 20 T2prep echo times (3.9 ± 2.3 ms vs. 2.2 ± 0.5 ms, p = 0.002). Similarly, reduced spatial variability was observed over all subjects and myocardial segments in T2 maps reconstructed from 4 T2prep echo times (12.8 ± 3.5 ms vs. 10.3 ± 2.5 ms, p < 0.001) and 20 T2prep echo times (9.7 ± 3.5 ms vs. 7.5 ± 1.4 ms, p = 0.005).Fig. 4


Impact of motion correction on reproducibility and spatial variability of quantitative myocardial T2 mapping.

Roujol S, Basha TA, Weingärtner S, Akçakaya M, Berg S, Manning WJ, Nezafat R - J Cardiovasc Magn Reson (2015)

Spatial variability of T2 mapping in all subjects using the T2P20TE sequence acquired under free breathing conditions with respiratory navigator gating. Spatial variability was evaluated for T2 maps reconstructed using only a subset of the T2prep echo times (0 ms, 25 ms, 50 ms, ∞) (4TEs) (a,b) and using all 20 T2prep echo times (20 TEs) (c,d). Average and standard deviation of T2 spatial variability is reported over all subjects for each segment (a,c) and over all segments for each subject (b,d). In-plane motion correction using ARCTIC reduced the spatial variability of T2 mapping
© Copyright Policy - open-access
Related In: Results  -  Collection

License 1 - License 2
Show All Figures
getmorefigures.php?uid=PMC4465156&req=5

Fig5: Spatial variability of T2 mapping in all subjects using the T2P20TE sequence acquired under free breathing conditions with respiratory navigator gating. Spatial variability was evaluated for T2 maps reconstructed using only a subset of the T2prep echo times (0 ms, 25 ms, 50 ms, ∞) (4TEs) (a,b) and using all 20 T2prep echo times (20 TEs) (c,d). Average and standard deviation of T2 spatial variability is reported over all subjects for each segment (a,c) and over all segments for each subject (b,d). In-plane motion correction using ARCTIC reduced the spatial variability of T2 mapping
Mentions: Figures 4 and 5 summarize the reproducibility and spatial variability of T2 measurements obtained in healthy subjects using the T2P20TE sequence. Results are shown for uncorrected and motion corrected T2 maps reconstructed using either 4 T2prep echo times or 20 T2prep echo times. Reproducibility and spatial variability are reported as uncorrected T2 maps vs. motion corrected T2 maps using ARCTIC. Improved reproducibility was observed over all subjects and myocardial segments in T2 maps reconstructed from 4 T2prep echo times (5.3 ± 2.5 ms vs. 4.0 ± 1.5 ms, p = 0.016) and 20 T2prep echo times (3.9 ± 2.3 ms vs. 2.2 ± 0.5 ms, p = 0.002). Similarly, reduced spatial variability was observed over all subjects and myocardial segments in T2 maps reconstructed from 4 T2prep echo times (12.8 ± 3.5 ms vs. 10.3 ± 2.5 ms, p < 0.001) and 20 T2prep echo times (9.7 ± 3.5 ms vs. 7.5 ± 1.4 ms, p = 0.005).Fig. 4

Bottom Line: In-plane myocardial motion was corrected using an adaptive registration of varying contrast-weighted images for improved tissue characterization (ARCTIC).ARCTIC led to increased DSC in BH data (0.85 ± 0.08 vs. 0.90 ± 0.02, p = 0.007), FB data (0.78 ± 0.13 vs. 0.90 ± 0.21, p < 0.001), and FB + NAV data (0.86 ± 0.05 vs. 0.90 ± 0.02, p = 0.002), and reduced MBE in BH data (0.90 ± 0.40 vs. 0.64 ± 0.19 mm, p = 0.005), FB data (1.21 ± 0.65 vs. 0.63 ± 0.10 mm, p < 0.001), and FB + NAV data (0.81 ± 0.21 vs. 0.63 ± 0.08 mm, p < 0.001).The ARCTIC technique substantially reduces spatial mis-alignment among T2-weighted images and improves the reproducibility and spatial variability of in-vivo T2 mapping.

View Article: PubMed Central - PubMed

Affiliation: Department of Medicine (Cardiovascular Division), Beth Israel Deaconess Medical Center, 330 Brookline Ave, Boston, MA, 02215, USA. sroujol@bidmc.harvard.edu.

ABSTRACT

Background: To evaluate and quantify the impact of a novel image-based motion correction technique in myocardial T2 mapping in terms of measurement reproducibility and spatial variability.

Methods: Twelve healthy adult subjects were imaged using breath-hold (BH), free breathing (FB), and free breathing with respiratory navigator gating (FB + NAV) myocardial T2 mapping sequences. Fifty patients referred for clinical CMR were imaged using the FB + NAV sequence. All sequences used a T2 prepared (T2prep) steady-state free precession acquisition. In-plane myocardial motion was corrected using an adaptive registration of varying contrast-weighted images for improved tissue characterization (ARCTIC). DICE similarity coefficient (DSC) and myocardial boundary errors (MBE) were measured to quantify the motion estimation accuracy in healthy subjects. T2 mapping reproducibility and spatial variability were evaluated in healthy subjects using 5 repetitions of the FB + NAV sequence with either 4 or 20 T2prep echo times (TE). Subjective T2 map quality was assessed in patients by an experienced reader using a 4-point scale (1-non diagnostic, 4-excellent).

Results: ARCTIC led to increased DSC in BH data (0.85 ± 0.08 vs. 0.90 ± 0.02, p = 0.007), FB data (0.78 ± 0.13 vs. 0.90 ± 0.21, p < 0.001), and FB + NAV data (0.86 ± 0.05 vs. 0.90 ± 0.02, p = 0.002), and reduced MBE in BH data (0.90 ± 0.40 vs. 0.64 ± 0.19 mm, p = 0.005), FB data (1.21 ± 0.65 vs. 0.63 ± 0.10 mm, p < 0.001), and FB + NAV data (0.81 ± 0.21 vs. 0.63 ± 0.08 mm, p < 0.001). Improved reproducibility (4TE: 5.3 ± 2.5 ms vs. 4.0 ± 1.5 ms, p = 0.016; 20TE: 3.9 ± 2.3 ms vs. 2.2 ± 0.5 ms, p = 0.002), reduced spatial variability (4TE: 12.8 ± 3.5 ms vs. 10.3 ± 2.5 ms, p < 0.001; 20TE: 9.7 ± 3.5 ms vs. 7.5 ± 1.4 ms) and improved subjective score of T2 map quality (3.43 ± 0.79 vs. 3.69 ± 0.55, p < 0.001) were obtained using ARCTIC.

Conclusions: The ARCTIC technique substantially reduces spatial mis-alignment among T2-weighted images and improves the reproducibility and spatial variability of in-vivo T2 mapping.

No MeSH data available.


Related in: MedlinePlus