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Impact of motion correction on reproducibility and spatial variability of quantitative myocardial T2 mapping.

Roujol S, Basha TA, Weingärtner S, Akçakaya M, Berg S, Manning WJ, Nezafat R - J Cardiovasc Magn Reson (2015)

Bottom Line: In-plane myocardial motion was corrected using an adaptive registration of varying contrast-weighted images for improved tissue characterization (ARCTIC).ARCTIC led to increased DSC in BH data (0.85 ± 0.08 vs. 0.90 ± 0.02, p = 0.007), FB data (0.78 ± 0.13 vs. 0.90 ± 0.21, p < 0.001), and FB + NAV data (0.86 ± 0.05 vs. 0.90 ± 0.02, p = 0.002), and reduced MBE in BH data (0.90 ± 0.40 vs. 0.64 ± 0.19 mm, p = 0.005), FB data (1.21 ± 0.65 vs. 0.63 ± 0.10 mm, p < 0.001), and FB + NAV data (0.81 ± 0.21 vs. 0.63 ± 0.08 mm, p < 0.001).The ARCTIC technique substantially reduces spatial mis-alignment among T2-weighted images and improves the reproducibility and spatial variability of in-vivo T2 mapping.

View Article: PubMed Central - PubMed

Affiliation: Department of Medicine (Cardiovascular Division), Beth Israel Deaconess Medical Center, 330 Brookline Ave, Boston, MA, 02215, USA. sroujol@bidmc.harvard.edu.

ABSTRACT

Background: To evaluate and quantify the impact of a novel image-based motion correction technique in myocardial T2 mapping in terms of measurement reproducibility and spatial variability.

Methods: Twelve healthy adult subjects were imaged using breath-hold (BH), free breathing (FB), and free breathing with respiratory navigator gating (FB + NAV) myocardial T2 mapping sequences. Fifty patients referred for clinical CMR were imaged using the FB + NAV sequence. All sequences used a T2 prepared (T2prep) steady-state free precession acquisition. In-plane myocardial motion was corrected using an adaptive registration of varying contrast-weighted images for improved tissue characterization (ARCTIC). DICE similarity coefficient (DSC) and myocardial boundary errors (MBE) were measured to quantify the motion estimation accuracy in healthy subjects. T2 mapping reproducibility and spatial variability were evaluated in healthy subjects using 5 repetitions of the FB + NAV sequence with either 4 or 20 T2prep echo times (TE). Subjective T2 map quality was assessed in patients by an experienced reader using a 4-point scale (1-non diagnostic, 4-excellent).

Results: ARCTIC led to increased DSC in BH data (0.85 ± 0.08 vs. 0.90 ± 0.02, p = 0.007), FB data (0.78 ± 0.13 vs. 0.90 ± 0.21, p < 0.001), and FB + NAV data (0.86 ± 0.05 vs. 0.90 ± 0.02, p = 0.002), and reduced MBE in BH data (0.90 ± 0.40 vs. 0.64 ± 0.19 mm, p = 0.005), FB data (1.21 ± 0.65 vs. 0.63 ± 0.10 mm, p < 0.001), and FB + NAV data (0.81 ± 0.21 vs. 0.63 ± 0.08 mm, p < 0.001). Improved reproducibility (4TE: 5.3 ± 2.5 ms vs. 4.0 ± 1.5 ms, p = 0.016; 20TE: 3.9 ± 2.3 ms vs. 2.2 ± 0.5 ms, p = 0.002), reduced spatial variability (4TE: 12.8 ± 3.5 ms vs. 10.3 ± 2.5 ms, p < 0.001; 20TE: 9.7 ± 3.5 ms vs. 7.5 ± 1.4 ms) and improved subjective score of T2 map quality (3.43 ± 0.79 vs. 3.69 ± 0.55, p < 0.001) were obtained using ARCTIC.

Conclusions: The ARCTIC technique substantially reduces spatial mis-alignment among T2-weighted images and improves the reproducibility and spatial variability of in-vivo T2 mapping.

No MeSH data available.


Related in: MedlinePlus

Dice similarity coefficient (DSC) (a,b) and myocardial boundary error (MBE) (c,d) obtained using the T2P4TE sequence under breath-hold (BH), free breathing (FB), and free breathing with respiratory navigator gating (FB + NAV). DSCs and MBEs of all T2-weighted images are shown in (a) and (b), respectively. (b) and (d) show DSC and MBE as average (central dot), standard deviation (box size) and minimum/maximum (whiskers) over all subjects and all T2-weighted images (except the T2prep = ∞ images). In-plane motion correction improves the DSC and reduces the MBE for all cases. Furthermore, motion corrected DSC and MBE were similar for all 3 acquisitions (i.e. BH, FB, FB + NAV)
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Fig2: Dice similarity coefficient (DSC) (a,b) and myocardial boundary error (MBE) (c,d) obtained using the T2P4TE sequence under breath-hold (BH), free breathing (FB), and free breathing with respiratory navigator gating (FB + NAV). DSCs and MBEs of all T2-weighted images are shown in (a) and (b), respectively. (b) and (d) show DSC and MBE as average (central dot), standard deviation (box size) and minimum/maximum (whiskers) over all subjects and all T2-weighted images (except the T2prep = ∞ images). In-plane motion correction improves the DSC and reduces the MBE for all cases. Furthermore, motion corrected DSC and MBE were similar for all 3 acquisitions (i.e. BH, FB, FB + NAV)

Mentions: Figure 2 shows quantitative metrics of motion accuracy (DSC and MBE) obtained in healthy subjects using the three aforementioned acquisition sequences. Increased DSC and reduced MBE were observed in each of the three acquisition sequences. In the remaining part of this paragraph, DSC and MBE are reported as (uncorrected data vs. motion corrected data using ARCTIC). On average for all subjects, the DSC increased in breath-hold data (0.85 ± 0.08 vs. 0.90 ± 0.02, p = 0.007), free breathing data (0.78 ± 0.13 vs. 0.90 ± 0.21, p < 0.001), and free breathing data with respiratory navigator gating (0.86 ± 0.05 vs. 0.90 ± 0.02, p = 0.002). The MBE decreased in breath-hold data (0.90 ± 0.40 vs. 0.64 ± 0.19 mm, p = 0.005), free breathing data (1.21 ± 0.65 vs. 0.63 ± 0.10 mm, p < 0.001), and free breathing data with respiratory navigator gating (0.81 ± 0.21 vs. 0.63 ± 0.08 mm, p < 0.001).Fig. 2


Impact of motion correction on reproducibility and spatial variability of quantitative myocardial T2 mapping.

Roujol S, Basha TA, Weingärtner S, Akçakaya M, Berg S, Manning WJ, Nezafat R - J Cardiovasc Magn Reson (2015)

Dice similarity coefficient (DSC) (a,b) and myocardial boundary error (MBE) (c,d) obtained using the T2P4TE sequence under breath-hold (BH), free breathing (FB), and free breathing with respiratory navigator gating (FB + NAV). DSCs and MBEs of all T2-weighted images are shown in (a) and (b), respectively. (b) and (d) show DSC and MBE as average (central dot), standard deviation (box size) and minimum/maximum (whiskers) over all subjects and all T2-weighted images (except the T2prep = ∞ images). In-plane motion correction improves the DSC and reduces the MBE for all cases. Furthermore, motion corrected DSC and MBE were similar for all 3 acquisitions (i.e. BH, FB, FB + NAV)
© Copyright Policy - open-access
Related In: Results  -  Collection

License 1 - License 2
Show All Figures
getmorefigures.php?uid=PMC4465156&req=5

Fig2: Dice similarity coefficient (DSC) (a,b) and myocardial boundary error (MBE) (c,d) obtained using the T2P4TE sequence under breath-hold (BH), free breathing (FB), and free breathing with respiratory navigator gating (FB + NAV). DSCs and MBEs of all T2-weighted images are shown in (a) and (b), respectively. (b) and (d) show DSC and MBE as average (central dot), standard deviation (box size) and minimum/maximum (whiskers) over all subjects and all T2-weighted images (except the T2prep = ∞ images). In-plane motion correction improves the DSC and reduces the MBE for all cases. Furthermore, motion corrected DSC and MBE were similar for all 3 acquisitions (i.e. BH, FB, FB + NAV)
Mentions: Figure 2 shows quantitative metrics of motion accuracy (DSC and MBE) obtained in healthy subjects using the three aforementioned acquisition sequences. Increased DSC and reduced MBE were observed in each of the three acquisition sequences. In the remaining part of this paragraph, DSC and MBE are reported as (uncorrected data vs. motion corrected data using ARCTIC). On average for all subjects, the DSC increased in breath-hold data (0.85 ± 0.08 vs. 0.90 ± 0.02, p = 0.007), free breathing data (0.78 ± 0.13 vs. 0.90 ± 0.21, p < 0.001), and free breathing data with respiratory navigator gating (0.86 ± 0.05 vs. 0.90 ± 0.02, p = 0.002). The MBE decreased in breath-hold data (0.90 ± 0.40 vs. 0.64 ± 0.19 mm, p = 0.005), free breathing data (1.21 ± 0.65 vs. 0.63 ± 0.10 mm, p < 0.001), and free breathing data with respiratory navigator gating (0.81 ± 0.21 vs. 0.63 ± 0.08 mm, p < 0.001).Fig. 2

Bottom Line: In-plane myocardial motion was corrected using an adaptive registration of varying contrast-weighted images for improved tissue characterization (ARCTIC).ARCTIC led to increased DSC in BH data (0.85 ± 0.08 vs. 0.90 ± 0.02, p = 0.007), FB data (0.78 ± 0.13 vs. 0.90 ± 0.21, p < 0.001), and FB + NAV data (0.86 ± 0.05 vs. 0.90 ± 0.02, p = 0.002), and reduced MBE in BH data (0.90 ± 0.40 vs. 0.64 ± 0.19 mm, p = 0.005), FB data (1.21 ± 0.65 vs. 0.63 ± 0.10 mm, p < 0.001), and FB + NAV data (0.81 ± 0.21 vs. 0.63 ± 0.08 mm, p < 0.001).The ARCTIC technique substantially reduces spatial mis-alignment among T2-weighted images and improves the reproducibility and spatial variability of in-vivo T2 mapping.

View Article: PubMed Central - PubMed

Affiliation: Department of Medicine (Cardiovascular Division), Beth Israel Deaconess Medical Center, 330 Brookline Ave, Boston, MA, 02215, USA. sroujol@bidmc.harvard.edu.

ABSTRACT

Background: To evaluate and quantify the impact of a novel image-based motion correction technique in myocardial T2 mapping in terms of measurement reproducibility and spatial variability.

Methods: Twelve healthy adult subjects were imaged using breath-hold (BH), free breathing (FB), and free breathing with respiratory navigator gating (FB + NAV) myocardial T2 mapping sequences. Fifty patients referred for clinical CMR were imaged using the FB + NAV sequence. All sequences used a T2 prepared (T2prep) steady-state free precession acquisition. In-plane myocardial motion was corrected using an adaptive registration of varying contrast-weighted images for improved tissue characterization (ARCTIC). DICE similarity coefficient (DSC) and myocardial boundary errors (MBE) were measured to quantify the motion estimation accuracy in healthy subjects. T2 mapping reproducibility and spatial variability were evaluated in healthy subjects using 5 repetitions of the FB + NAV sequence with either 4 or 20 T2prep echo times (TE). Subjective T2 map quality was assessed in patients by an experienced reader using a 4-point scale (1-non diagnostic, 4-excellent).

Results: ARCTIC led to increased DSC in BH data (0.85 ± 0.08 vs. 0.90 ± 0.02, p = 0.007), FB data (0.78 ± 0.13 vs. 0.90 ± 0.21, p < 0.001), and FB + NAV data (0.86 ± 0.05 vs. 0.90 ± 0.02, p = 0.002), and reduced MBE in BH data (0.90 ± 0.40 vs. 0.64 ± 0.19 mm, p = 0.005), FB data (1.21 ± 0.65 vs. 0.63 ± 0.10 mm, p < 0.001), and FB + NAV data (0.81 ± 0.21 vs. 0.63 ± 0.08 mm, p < 0.001). Improved reproducibility (4TE: 5.3 ± 2.5 ms vs. 4.0 ± 1.5 ms, p = 0.016; 20TE: 3.9 ± 2.3 ms vs. 2.2 ± 0.5 ms, p = 0.002), reduced spatial variability (4TE: 12.8 ± 3.5 ms vs. 10.3 ± 2.5 ms, p < 0.001; 20TE: 9.7 ± 3.5 ms vs. 7.5 ± 1.4 ms) and improved subjective score of T2 map quality (3.43 ± 0.79 vs. 3.69 ± 0.55, p < 0.001) were obtained using ARCTIC.

Conclusions: The ARCTIC technique substantially reduces spatial mis-alignment among T2-weighted images and improves the reproducibility and spatial variability of in-vivo T2 mapping.

No MeSH data available.


Related in: MedlinePlus