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Recent Advances in Hydroxyapatite Scaffolds Containing Mesenchymal Stem Cells.

Michel J, Penna M, Kochen J, Cheung H - Stem Cells Int (2015)

Bottom Line: Mesenchymal stem cells (MSCs) are one of the most studied stem cells used in combination with scaffolds.These cells differentiate along the osteogenic lineage when seeded on hydroxyapatite containing scaffolds and can be used as a therapeutic option to regenerate various tissues.Further, in order to maintain a progressive scope of the field this review article will only focus on literature utilizing adult human derived MSCs (hMSCs) published in the last three years.

View Article: PubMed Central - PubMed

Affiliation: Department of Biomedical Engineering, College of Engineering, University of Miami, 1251 Memorial Drive, MEA 219A, Coral Gables, FL 33146, USA.

ABSTRACT
Modern day tissue engineering and cellular therapies have gravitated toward using stem cells with scaffolds as a dynamic modality to aid in differentiation and tissue regeneration. Mesenchymal stem cells (MSCs) are one of the most studied stem cells used in combination with scaffolds. These cells differentiate along the osteogenic lineage when seeded on hydroxyapatite containing scaffolds and can be used as a therapeutic option to regenerate various tissues. In recent years, the combination of hydroxyapatite and natural or synthetic polymers has been studied extensively. Due to the interest in these scaffolds, this review will cover the wide range of hydroxyapatite containing scaffolds used with MSCs for in vitro and in vivo experiments. Further, in order to maintain a progressive scope of the field this review article will only focus on literature utilizing adult human derived MSCs (hMSCs) published in the last three years.

No MeSH data available.


Related in: MedlinePlus

Graphic scheme of the categorization of topics in this review. For the purposes of this review, if materials were more than 50% natural they were considered natural or vice versa.
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Related In: Results  -  Collection


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fig1: Graphic scheme of the categorization of topics in this review. For the purposes of this review, if materials were more than 50% natural they were considered natural or vice versa.

Mentions: In the pursuit of using hydroxyapatite containing scaffolds for regenerative purposes, the choice of supporting material is often paramount. One may choose to combine HA with another material for a multitude of reasons like improved strength, increased porosity, altered cell binding abilities, and so forth [42]. In this line of thought, a great variety of papers have been dedicated to the characterization of scaffolds synthesized via the combinatorial approach of HA with another supporting material [43]. Due to the breadth of materials used in the literature for the treatment of specific osteodiseases, a background into the materials is often necessary. Therefore, this review will not only cover how HA containing scaffolds have been used to treat defects, but also introduce the materials used in terms of their osteogenic potential. We present Figure 1 representing how the information in this review is categorized.


Recent Advances in Hydroxyapatite Scaffolds Containing Mesenchymal Stem Cells.

Michel J, Penna M, Kochen J, Cheung H - Stem Cells Int (2015)

Graphic scheme of the categorization of topics in this review. For the purposes of this review, if materials were more than 50% natural they were considered natural or vice versa.
© Copyright Policy - open-access
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC4464687&req=5

fig1: Graphic scheme of the categorization of topics in this review. For the purposes of this review, if materials were more than 50% natural they were considered natural or vice versa.
Mentions: In the pursuit of using hydroxyapatite containing scaffolds for regenerative purposes, the choice of supporting material is often paramount. One may choose to combine HA with another material for a multitude of reasons like improved strength, increased porosity, altered cell binding abilities, and so forth [42]. In this line of thought, a great variety of papers have been dedicated to the characterization of scaffolds synthesized via the combinatorial approach of HA with another supporting material [43]. Due to the breadth of materials used in the literature for the treatment of specific osteodiseases, a background into the materials is often necessary. Therefore, this review will not only cover how HA containing scaffolds have been used to treat defects, but also introduce the materials used in terms of their osteogenic potential. We present Figure 1 representing how the information in this review is categorized.

Bottom Line: Mesenchymal stem cells (MSCs) are one of the most studied stem cells used in combination with scaffolds.These cells differentiate along the osteogenic lineage when seeded on hydroxyapatite containing scaffolds and can be used as a therapeutic option to regenerate various tissues.Further, in order to maintain a progressive scope of the field this review article will only focus on literature utilizing adult human derived MSCs (hMSCs) published in the last three years.

View Article: PubMed Central - PubMed

Affiliation: Department of Biomedical Engineering, College of Engineering, University of Miami, 1251 Memorial Drive, MEA 219A, Coral Gables, FL 33146, USA.

ABSTRACT
Modern day tissue engineering and cellular therapies have gravitated toward using stem cells with scaffolds as a dynamic modality to aid in differentiation and tissue regeneration. Mesenchymal stem cells (MSCs) are one of the most studied stem cells used in combination with scaffolds. These cells differentiate along the osteogenic lineage when seeded on hydroxyapatite containing scaffolds and can be used as a therapeutic option to regenerate various tissues. In recent years, the combination of hydroxyapatite and natural or synthetic polymers has been studied extensively. Due to the interest in these scaffolds, this review will cover the wide range of hydroxyapatite containing scaffolds used with MSCs for in vitro and in vivo experiments. Further, in order to maintain a progressive scope of the field this review article will only focus on literature utilizing adult human derived MSCs (hMSCs) published in the last three years.

No MeSH data available.


Related in: MedlinePlus