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The association between arterial stiffness and carotid intima-media thickness in patients with known cardiovascular risk factors.

Suceava I, Lighezan D, Serban C, Lighezan R, Gurban C, Dragan S - Clujul Med (2013)

Bottom Line: Patients with CAD had increased values of aortic PWV compared with patients without CAD and CON group (12.5±0.7 vs 10.9±0.6 vs 8.5±0.6 m/s, all p<0.001).The values of carotid IMT were significantly higher in CAD patients as compared to patients without CAD and CON group (1±0.05 versus 1.0±0.07 versus 0.7±0.08 mm, all p<0.001).The carotid IMT significantly correlated with aortic PWV (r=0.787, p<0.001).

View Article: PubMed Central - PubMed

Affiliation: Victor Babeş University of Medicine and Pharmacy, Timişoara, Romania.

ABSTRACT

Objectives: The aim of this study was to evaluate the relationship between pulse wave velocity and carotid intima-media thickness (IMT) in patients with different cardiovascular risk factors.

Material and methods: This prospective study included 223 patients with at least 2 risk factors for atherosclerosis, divided based on the presence of coronary artery disease (CAD): 140 patients with angiographically documented CAD and 83 patients without CAD. The patients were compared with a control group of 74 healthy age-matched subjects (CON). We determined the following parameters: blood pressure, total cholesterol (TC), triglycerides (TG), LDL-cholesterol, HDL-cholesterol, fasting serum glucose and renal parameters: blood urea nitrogen, serum creatinine, and uric acid levels in all patients. Arterial stiffness was measured with non-invasive oscillometric Arteriograph device (Tensiomed Ltd., Budapest, Hungary) and carotid scan was performed with B-mode ultrasound.

Results: Patients with CAD had increased values of aortic PWV compared with patients without CAD and CON group (12.5±0.7 vs 10.9±0.6 vs 8.5±0.6 m/s, all p<0.001). The values of carotid IMT were significantly higher in CAD patients as compared to patients without CAD and CON group (1±0.05 versus 1.0±0.07 versus 0.7±0.08 mm, all p<0.001). The carotid IMT significantly correlated with aortic PWV (r=0.787, p<0.001).

Conclusions: Carotid IMT and aortic PWV are useful non-invasive methods for atherosclerosis detection in patients with known cardiovascular risk factors. Both determinations in the same patient will increase the clinical relevance.

No MeSH data available.


Related in: MedlinePlus

The histograms of aortic PWV in the studied groups.
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f1-cm-86-222: The histograms of aortic PWV in the studied groups.

Mentions: The values of carotid IMT were significantly higher in CAD patients as compared to patients without CAD and CON group (1±0.05 versus 1.0±0.07 versus 0.7±0.08 mm, p<0.001) (Figure 1 and Figure 2).


The association between arterial stiffness and carotid intima-media thickness in patients with known cardiovascular risk factors.

Suceava I, Lighezan D, Serban C, Lighezan R, Gurban C, Dragan S - Clujul Med (2013)

The histograms of aortic PWV in the studied groups.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4462495&req=5

f1-cm-86-222: The histograms of aortic PWV in the studied groups.
Mentions: The values of carotid IMT were significantly higher in CAD patients as compared to patients without CAD and CON group (1±0.05 versus 1.0±0.07 versus 0.7±0.08 mm, p<0.001) (Figure 1 and Figure 2).

Bottom Line: Patients with CAD had increased values of aortic PWV compared with patients without CAD and CON group (12.5±0.7 vs 10.9±0.6 vs 8.5±0.6 m/s, all p<0.001).The values of carotid IMT were significantly higher in CAD patients as compared to patients without CAD and CON group (1±0.05 versus 1.0±0.07 versus 0.7±0.08 mm, all p<0.001).The carotid IMT significantly correlated with aortic PWV (r=0.787, p<0.001).

View Article: PubMed Central - PubMed

Affiliation: Victor Babeş University of Medicine and Pharmacy, Timişoara, Romania.

ABSTRACT

Objectives: The aim of this study was to evaluate the relationship between pulse wave velocity and carotid intima-media thickness (IMT) in patients with different cardiovascular risk factors.

Material and methods: This prospective study included 223 patients with at least 2 risk factors for atherosclerosis, divided based on the presence of coronary artery disease (CAD): 140 patients with angiographically documented CAD and 83 patients without CAD. The patients were compared with a control group of 74 healthy age-matched subjects (CON). We determined the following parameters: blood pressure, total cholesterol (TC), triglycerides (TG), LDL-cholesterol, HDL-cholesterol, fasting serum glucose and renal parameters: blood urea nitrogen, serum creatinine, and uric acid levels in all patients. Arterial stiffness was measured with non-invasive oscillometric Arteriograph device (Tensiomed Ltd., Budapest, Hungary) and carotid scan was performed with B-mode ultrasound.

Results: Patients with CAD had increased values of aortic PWV compared with patients without CAD and CON group (12.5±0.7 vs 10.9±0.6 vs 8.5±0.6 m/s, all p<0.001). The values of carotid IMT were significantly higher in CAD patients as compared to patients without CAD and CON group (1±0.05 versus 1.0±0.07 versus 0.7±0.08 mm, all p<0.001). The carotid IMT significantly correlated with aortic PWV (r=0.787, p<0.001).

Conclusions: Carotid IMT and aortic PWV are useful non-invasive methods for atherosclerosis detection in patients with known cardiovascular risk factors. Both determinations in the same patient will increase the clinical relevance.

No MeSH data available.


Related in: MedlinePlus