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Evaluation of serum β-hCG and PAPP-A levels in pregnant women at risk of developing preeclampsia.

Oancea MD, Costin N, Pop DM, Ciortea R, Mihu D - Clujul Med (2013)

Bottom Line: We performed a prospective longitudinal study on 120 pregnant women divided into two groups according to the evolution of pregnancy: group I - 26 pregnant women who developed preeclampsia and group II - 94 pregnant women who did not develop preeclampsia and had a physiological evolution of pregnancy.Our results indicate the association between high β-hCG levels in the first and second trimesters of pregnancy and the development of PE, β-hCG having the highest predictive power in the second trimester.Increased β-hCG levels in the first and second trimesters of pregnancy and low PAPP-A levels in the second trimester of pregnancy are associated with a higher risk for PE, the study providing only a modest efficiency of the prediction capacity.

View Article: PubMed Central - PubMed

Affiliation: Department of Obstetrics and Gynecology II, "Iuliu Hatieganu" University of Medicine and Pharmacy, Cluj-Napoca, Romania.

ABSTRACT

Background and aim: Preeclampsia remains a major problem of modern obstetrics with insufficiently elucidated etiology; early detection would diminish maternal and fetal mortality and morbidity. The aim of this study was to determine the serum values of β-hCG in the first and second trimesters of pregnancy and PAPP-A values in the first trimester of pregnancy in pregnant women with risk factors for preeclampsia, in order to evaluate their relevance in the prediction of this disorder.

Material and methods: We performed a prospective longitudinal study on 120 pregnant women divided into two groups according to the evolution of pregnancy: group I - 26 pregnant women who developed preeclampsia and group II - 94 pregnant women who did not develop preeclampsia and had a physiological evolution of pregnancy.

Results: Our results indicate the association between high β-hCG levels in the first and second trimesters of pregnancy and the development of PE, β-hCG having the highest predictive power in the second trimester. We also obtained a positive association between low serum levels in PAPP-A in the first trimester and onset of PE. The predictive power of conjugated β-hCG and PAPP-A values in the first trimester of pregnancy was better that any other marker analyzed separately.

Conclusions: Increased β-hCG levels in the first and second trimesters of pregnancy and low PAPP-A levels in the second trimester of pregnancy are associated with a higher risk for PE, the study providing only a modest efficiency of the prediction capacity.

No MeSH data available.


Related in: MedlinePlus

The ROC curve associated with the binary logit model. Explanatory variable: β-HCG, 1st trimester
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f1-cm-86-347: The ROC curve associated with the binary logit model. Explanatory variable: β-HCG, 1st trimester


Evaluation of serum β-hCG and PAPP-A levels in pregnant women at risk of developing preeclampsia.

Oancea MD, Costin N, Pop DM, Ciortea R, Mihu D - Clujul Med (2013)

The ROC curve associated with the binary logit model. Explanatory variable: β-HCG, 1st trimester
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4462458&req=5

f1-cm-86-347: The ROC curve associated with the binary logit model. Explanatory variable: β-HCG, 1st trimester
Bottom Line: We performed a prospective longitudinal study on 120 pregnant women divided into two groups according to the evolution of pregnancy: group I - 26 pregnant women who developed preeclampsia and group II - 94 pregnant women who did not develop preeclampsia and had a physiological evolution of pregnancy.Our results indicate the association between high β-hCG levels in the first and second trimesters of pregnancy and the development of PE, β-hCG having the highest predictive power in the second trimester.Increased β-hCG levels in the first and second trimesters of pregnancy and low PAPP-A levels in the second trimester of pregnancy are associated with a higher risk for PE, the study providing only a modest efficiency of the prediction capacity.

View Article: PubMed Central - PubMed

Affiliation: Department of Obstetrics and Gynecology II, "Iuliu Hatieganu" University of Medicine and Pharmacy, Cluj-Napoca, Romania.

ABSTRACT

Background and aim: Preeclampsia remains a major problem of modern obstetrics with insufficiently elucidated etiology; early detection would diminish maternal and fetal mortality and morbidity. The aim of this study was to determine the serum values of β-hCG in the first and second trimesters of pregnancy and PAPP-A values in the first trimester of pregnancy in pregnant women with risk factors for preeclampsia, in order to evaluate their relevance in the prediction of this disorder.

Material and methods: We performed a prospective longitudinal study on 120 pregnant women divided into two groups according to the evolution of pregnancy: group I - 26 pregnant women who developed preeclampsia and group II - 94 pregnant women who did not develop preeclampsia and had a physiological evolution of pregnancy.

Results: Our results indicate the association between high β-hCG levels in the first and second trimesters of pregnancy and the development of PE, β-hCG having the highest predictive power in the second trimester. We also obtained a positive association between low serum levels in PAPP-A in the first trimester and onset of PE. The predictive power of conjugated β-hCG and PAPP-A values in the first trimester of pregnancy was better that any other marker analyzed separately.

Conclusions: Increased β-hCG levels in the first and second trimesters of pregnancy and low PAPP-A levels in the second trimester of pregnancy are associated with a higher risk for PE, the study providing only a modest efficiency of the prediction capacity.

No MeSH data available.


Related in: MedlinePlus