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Primary non-Hodgkin lymphoma of the orbit presenting with massive bilateral periorbital tumors.

Tőrők-Vistai T, Bojan A, Cucuianu A, Zsoldos A - Clujul Med (2013)

Bottom Line: Extranodal onset can be seen in approximately 25-40% of the cases of non- Hodgkin lymphomas and diagnosis is often difficult due to nonspecific symptoms.Orbital lymphomas represent approximately 50% of the orbital malignancies.A particularity of this case is the presence of massive periorbital tumors on admission to the hospital, incorporating the eye globes completely and causing impressive facial deformity.

View Article: PubMed Central - PubMed

Affiliation: Department of Hematology, Iuliu Hatieganu University of Medicine and Pharmacy, Cluj-Napoca, Romania.

ABSTRACT
Extranodal onset can be seen in approximately 25-40% of the cases of non- Hodgkin lymphomas and diagnosis is often difficult due to nonspecific symptoms. Orbital lymphomas represent approximately 50% of the orbital malignancies. Common symptoms and signs at presentation are: palpable tumor, exophtalmia, dyplopia and decreased vision. Diagnosis can be made only by biopsy and early treatment is important in order to increase the chance of cure. We present the case of a patient whose diagnosis and treatment were delayed due to refusal of biopsy and, although complete remission of lymphoma was obtained, the vision loss was permanent because of prolonged compression on the optic nerves. A particularity of this case is the presence of massive periorbital tumors on admission to the hospital, incorporating the eye globes completely and causing impressive facial deformity.

No MeSH data available.


Related in: MedlinePlus

Resorption of the orbital tumors after chemotherapy
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f4-cm-86-380: Resorption of the orbital tumors after chemotherapy

Mentions: The patient was diagnosed with stage IVB diffuse large B-cell primary orbital lymphoma and R-CHOP (Rituximab + Cyclophosphamide, Adriblastin, Vincristin and Prednison) chemotherapy was started, which produced a rapid response. After 2 months, the patient presented with relapse. R-ICE ( Rituximab + Iphosphamide, Carboplatin and Etoposide) second-line chemotherapy was started and complete remission was obtained after 4 cycles (fig. 5). However, the patient did not regain his vision due to optic nerve atrophy. He did not return for completion of the chemotherapy cycles, nor for follow-up.


Primary non-Hodgkin lymphoma of the orbit presenting with massive bilateral periorbital tumors.

Tőrők-Vistai T, Bojan A, Cucuianu A, Zsoldos A - Clujul Med (2013)

Resorption of the orbital tumors after chemotherapy
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4462449&req=5

f4-cm-86-380: Resorption of the orbital tumors after chemotherapy
Mentions: The patient was diagnosed with stage IVB diffuse large B-cell primary orbital lymphoma and R-CHOP (Rituximab + Cyclophosphamide, Adriblastin, Vincristin and Prednison) chemotherapy was started, which produced a rapid response. After 2 months, the patient presented with relapse. R-ICE ( Rituximab + Iphosphamide, Carboplatin and Etoposide) second-line chemotherapy was started and complete remission was obtained after 4 cycles (fig. 5). However, the patient did not regain his vision due to optic nerve atrophy. He did not return for completion of the chemotherapy cycles, nor for follow-up.

Bottom Line: Extranodal onset can be seen in approximately 25-40% of the cases of non- Hodgkin lymphomas and diagnosis is often difficult due to nonspecific symptoms.Orbital lymphomas represent approximately 50% of the orbital malignancies.A particularity of this case is the presence of massive periorbital tumors on admission to the hospital, incorporating the eye globes completely and causing impressive facial deformity.

View Article: PubMed Central - PubMed

Affiliation: Department of Hematology, Iuliu Hatieganu University of Medicine and Pharmacy, Cluj-Napoca, Romania.

ABSTRACT
Extranodal onset can be seen in approximately 25-40% of the cases of non- Hodgkin lymphomas and diagnosis is often difficult due to nonspecific symptoms. Orbital lymphomas represent approximately 50% of the orbital malignancies. Common symptoms and signs at presentation are: palpable tumor, exophtalmia, dyplopia and decreased vision. Diagnosis can be made only by biopsy and early treatment is important in order to increase the chance of cure. We present the case of a patient whose diagnosis and treatment were delayed due to refusal of biopsy and, although complete remission of lymphoma was obtained, the vision loss was permanent because of prolonged compression on the optic nerves. A particularity of this case is the presence of massive periorbital tumors on admission to the hospital, incorporating the eye globes completely and causing impressive facial deformity.

No MeSH data available.


Related in: MedlinePlus