Intratumoral androgen metabolism and actions in invasive lobular carcinoma of the breast.
Bottom Line: In ILC cases the status of 5αRed1 and 17βHSD5 was inversely correlated with tumor size (P = 0.0053) and nuclear grade (P = 0.0290), and significantly associated with better overall survival of the patients (P = 0.0059).These correlations suggest one protective mode of androgen action could be through modulation of estrogen metabolism.Results of our present study indicated that androgen-producing enzymes could play pivotal protective roles in AR-enriched ILC cases.
Affiliation: Department of Pathology, Tohoku University Graduate School of Medicine, Sendai.Show MeSH
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Mentions: The AR-negative cases (n = 4) were excluded to analyze the effects of androgen metabolizing enzymes on AR-mediated actions in ILC. We tentatively classified the 174 AR-positive ILC cases into the following two groups: a 17βHSD5 and 5αRed1 double-negative cohort of patients lacking any form of androgen synthesis (45 samples); and a group encompassing all other cases (129 samples) according to the potential local production of androgens. The associations between the status of intratumoral androgenic enzymes and clinicopathological parameters of the patients are summarized in Table 3. Age, menopausal status, ER, Her2, and Ki-67 status were not correlated with the status of intratumoral androgenic enzymes. Stage and the status of PR tended to be inversely correlated with that of intratumoral androgenic enzymes (P = 0.0720 and P = 0.0663, respectively). Tumor size and nuclear grade were inversely correlated with the status of intratumoral androgen metabolizing enzymes (P = 0.0053 and P = 0.0290, respectively). The mean tumor size was also higher in the 17βHSD5–5αRed1 double-negative group of patients (Fig. 2), suggesting the correlation of tumor size with the presence of intratumoral androgenic enzymes.
Affiliation: Department of Pathology, Tohoku University Graduate School of Medicine, Sendai.