Intratumoral androgen metabolism and actions in invasive lobular carcinoma of the breast.
Bottom Line: In ILC cases the status of 5αRed1 and 17βHSD5 was inversely correlated with tumor size (P = 0.0053) and nuclear grade (P = 0.0290), and significantly associated with better overall survival of the patients (P = 0.0059).These correlations suggest one protective mode of androgen action could be through modulation of estrogen metabolism.Results of our present study indicated that androgen-producing enzymes could play pivotal protective roles in AR-enriched ILC cases.
Affiliation: Department of Pathology, Tohoku University Graduate School of Medicine, Sendai.Show MeSH
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Mentions: Androgen receptor immunoreactivity was detected in the nuclei of tumor cells, and 17βHSD5 and 5αRed1 immunoreactivity in the cytoplasm of tumor cells (Fig. 1). Androgen receptor was highly prevalent with positive nuclei detected in almost all the carcinoma cells in ILC. In ILC, AR-positive cases (defined as >10% LI) were 97.8% (174 cases out of 178) and the mean value of AR LI was 90.6 ± 1.4 (range, 0–100%). The proportion of 17βHSD5- and 5αRed1-positive cases (defined as >50% tumor cells of cytoplasmic immunoreactivity) were 61.8% and 53.4%, respectively, with 34.8% double-positive for both enzymes.
Affiliation: Department of Pathology, Tohoku University Graduate School of Medicine, Sendai.