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Galectin-4 serves as a prognostic biomarker for the early recurrence / metastasis of hepatocellular carcinoma.

Cai Z, Zeng Y, Xu B, Gao Y, Wang S, Zeng J, Chen L, Huang A, Liu X, Liu J - Cancer Sci. (2014)

Bottom Line: Galectin-4 is a multifunctional lectin found at both intracellular and extracellular sites.Here we report that galectin-4 was significantly downregulated in early recurrent/metastatic HCC patients, when compared to non-recurrent/metastatic HCC patients.Combined with clinicopathological features, the higher serologic level of galectin-4 was well associated with more aggressive characteristics of HCC.

View Article: PubMed Central - PubMed

Affiliation: Mengchao Hepatobiliary Hospital of Fujian Medical University, Fuzhou, China; The Liver Center of Fujian Province, Fujian Medical University, Fuzhou, China.

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Related in: MedlinePlus

Kaplan–Meier analysis of the association between galectin-4 expression and recurrence/metastasis as well as the survival of patients with hepatocellular carcinoma. Those patients with negative galectin-4 expression (n = 112) had significantly higher recurrence rate and shorter overall survival time than those with positive galectin-4 expression (n = 89).
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fig03: Kaplan–Meier analysis of the association between galectin-4 expression and recurrence/metastasis as well as the survival of patients with hepatocellular carcinoma. Those patients with negative galectin-4 expression (n = 112) had significantly higher recurrence rate and shorter overall survival time than those with positive galectin-4 expression (n = 89).

Mentions: To further evaluate the prognostic value of galectin-4 expression in HCC, Cox's proportional hazards model and Kaplan–Meier analysis was used to calculate the effect of galectin-4 expression on TTR and OS time. As shown in Table 3, Cox's multivariate proportional hazards model showed that galectin-4 expression was an independent poor prognostic factor for TTR (P = 0.003) and OS time (P = 0.002) in HCC after curative resection. Kaplan–Meier analysis showed that patients with low galectin-4 expression had a higher recurrence/metastasis rate (log–rank, P < 0.001, Fig. 3a) and shorter OS time (log–rank, P < 0.001, Fig. 3b) than those with high galectin-4 expression. These data suggested that galectin-4 would be a very promising prognostic biomarker for HCC, but might need further larger-scale, multicenter clinical study.


Galectin-4 serves as a prognostic biomarker for the early recurrence / metastasis of hepatocellular carcinoma.

Cai Z, Zeng Y, Xu B, Gao Y, Wang S, Zeng J, Chen L, Huang A, Liu X, Liu J - Cancer Sci. (2014)

Kaplan–Meier analysis of the association between galectin-4 expression and recurrence/metastasis as well as the survival of patients with hepatocellular carcinoma. Those patients with negative galectin-4 expression (n = 112) had significantly higher recurrence rate and shorter overall survival time than those with positive galectin-4 expression (n = 89).
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4462376&req=5

fig03: Kaplan–Meier analysis of the association between galectin-4 expression and recurrence/metastasis as well as the survival of patients with hepatocellular carcinoma. Those patients with negative galectin-4 expression (n = 112) had significantly higher recurrence rate and shorter overall survival time than those with positive galectin-4 expression (n = 89).
Mentions: To further evaluate the prognostic value of galectin-4 expression in HCC, Cox's proportional hazards model and Kaplan–Meier analysis was used to calculate the effect of galectin-4 expression on TTR and OS time. As shown in Table 3, Cox's multivariate proportional hazards model showed that galectin-4 expression was an independent poor prognostic factor for TTR (P = 0.003) and OS time (P = 0.002) in HCC after curative resection. Kaplan–Meier analysis showed that patients with low galectin-4 expression had a higher recurrence/metastasis rate (log–rank, P < 0.001, Fig. 3a) and shorter OS time (log–rank, P < 0.001, Fig. 3b) than those with high galectin-4 expression. These data suggested that galectin-4 would be a very promising prognostic biomarker for HCC, but might need further larger-scale, multicenter clinical study.

Bottom Line: Galectin-4 is a multifunctional lectin found at both intracellular and extracellular sites.Here we report that galectin-4 was significantly downregulated in early recurrent/metastatic HCC patients, when compared to non-recurrent/metastatic HCC patients.Combined with clinicopathological features, the higher serologic level of galectin-4 was well associated with more aggressive characteristics of HCC.

View Article: PubMed Central - PubMed

Affiliation: Mengchao Hepatobiliary Hospital of Fujian Medical University, Fuzhou, China; The Liver Center of Fujian Province, Fujian Medical University, Fuzhou, China.

Show MeSH
Related in: MedlinePlus