Galectin-4 serves as a prognostic biomarker for the early recurrence / metastasis of hepatocellular carcinoma.
Bottom Line: Galectin-4 is a multifunctional lectin found at both intracellular and extracellular sites.Here we report that galectin-4 was significantly downregulated in early recurrent/metastatic HCC patients, when compared to non-recurrent/metastatic HCC patients.Combined with clinicopathological features, the higher serologic level of galectin-4 was well associated with more aggressive characteristics of HCC.
Affiliation: Mengchao Hepatobiliary Hospital of Fujian Medical University, Fuzhou, China; The Liver Center of Fujian Province, Fujian Medical University, Fuzhou, China.Show MeSH
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Mentions: To further evaluate the prognostic value of galectin-4 expression in HCC, Cox's proportional hazards model and Kaplan–Meier analysis was used to calculate the effect of galectin-4 expression on TTR and OS time. As shown in Table 3, Cox's multivariate proportional hazards model showed that galectin-4 expression was an independent poor prognostic factor for TTR (P = 0.003) and OS time (P = 0.002) in HCC after curative resection. Kaplan–Meier analysis showed that patients with low galectin-4 expression had a higher recurrence/metastasis rate (log–rank, P < 0.001, Fig. 3a) and shorter OS time (log–rank, P < 0.001, Fig. 3b) than those with high galectin-4 expression. These data suggested that galectin-4 would be a very promising prognostic biomarker for HCC, but might need further larger-scale, multicenter clinical study.
Affiliation: Mengchao Hepatobiliary Hospital of Fujian Medical University, Fuzhou, China; The Liver Center of Fujian Province, Fujian Medical University, Fuzhou, China.