Expression of L-type amino acid transporter 1 (LAT1) as a prognostic and therapeutic indicator in multiple myeloma.
Bottom Line: In 43 patients treated with melphalan and prednisolone, the overall response rate was significantly higher in the high LAT1 expression group (60.0%) than in the low LAT1 expression group (17.6%) (P = 0.03).Multivariate analysis confirmed that high expression of LAT1 was a significant prognostic factor for predicting poor overall survival independently from the International Staging System (both P = 0.01).Here, we show that the overexpression of LAT1 is significantly associated with high proliferation and poor prognosis in newly diagnosed MM patients.
Affiliation: Department of Hematology, National Hospital Organization Nishigunma Hospital, Gunma, Japan.Show MeSH
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Mentions: Analysis with Spearman's rank correlation showed that the LAT1 score was significantly correlated with Ki-67 index (r = 0.631, P < 0.001), CD98 score (r = 0.598, P < 0.001), and the ISS stage (r = 0.256, P = 0.01) (Table 2). Figure 2 shows that the LAT1 score is closely correlated with Ki-67 index.
Affiliation: Department of Hematology, National Hospital Organization Nishigunma Hospital, Gunma, Japan.