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Expression of L-type amino acid transporter 1 (LAT1) as a prognostic and therapeutic indicator in multiple myeloma.

Isoda A, Kaira K, Iwashina M, Oriuchi N, Tominaga H, Nagamori S, Kanai Y, Oyama T, Asao T, Matsumoto M, Sawamura M - Cancer Sci. (2014)

Bottom Line: In 43 patients treated with melphalan and prednisolone, the overall response rate was significantly higher in the high LAT1 expression group (60.0%) than in the low LAT1 expression group (17.6%) (P = 0.03).Multivariate analysis confirmed that high expression of LAT1 was a significant prognostic factor for predicting poor overall survival independently from the International Staging System (both P = 0.01).Here, we show that the overexpression of LAT1 is significantly associated with high proliferation and poor prognosis in newly diagnosed MM patients.

View Article: PubMed Central - PubMed

Affiliation: Department of Hematology, National Hospital Organization Nishigunma Hospital, Gunma, Japan.

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Comparison of Ki-67 index in 100 newly diagnosed multiple myeloma patients with L-type amino acid transporter 1 (LAT1) immunohistochemical staining scores of 0–3+ in bone marrow tissue. The boundaries of the box show 25th and 75th percentiles, and the line within the box is the median. Whiskers show 10th and 90th percentiles, and the circles indicate outliers.
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fig02: Comparison of Ki-67 index in 100 newly diagnosed multiple myeloma patients with L-type amino acid transporter 1 (LAT1) immunohistochemical staining scores of 0–3+ in bone marrow tissue. The boundaries of the box show 25th and 75th percentiles, and the line within the box is the median. Whiskers show 10th and 90th percentiles, and the circles indicate outliers.

Mentions: Analysis with Spearman's rank correlation showed that the LAT1 score was significantly correlated with Ki-67 index (r = 0.631, P < 0.001), CD98 score (r = 0.598, P < 0.001), and the ISS stage (r = 0.256, P = 0.01) (Table 2). Figure 2 shows that the LAT1 score is closely correlated with Ki-67 index.


Expression of L-type amino acid transporter 1 (LAT1) as a prognostic and therapeutic indicator in multiple myeloma.

Isoda A, Kaira K, Iwashina M, Oriuchi N, Tominaga H, Nagamori S, Kanai Y, Oyama T, Asao T, Matsumoto M, Sawamura M - Cancer Sci. (2014)

Comparison of Ki-67 index in 100 newly diagnosed multiple myeloma patients with L-type amino acid transporter 1 (LAT1) immunohistochemical staining scores of 0–3+ in bone marrow tissue. The boundaries of the box show 25th and 75th percentiles, and the line within the box is the median. Whiskers show 10th and 90th percentiles, and the circles indicate outliers.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4462375&req=5

fig02: Comparison of Ki-67 index in 100 newly diagnosed multiple myeloma patients with L-type amino acid transporter 1 (LAT1) immunohistochemical staining scores of 0–3+ in bone marrow tissue. The boundaries of the box show 25th and 75th percentiles, and the line within the box is the median. Whiskers show 10th and 90th percentiles, and the circles indicate outliers.
Mentions: Analysis with Spearman's rank correlation showed that the LAT1 score was significantly correlated with Ki-67 index (r = 0.631, P < 0.001), CD98 score (r = 0.598, P < 0.001), and the ISS stage (r = 0.256, P = 0.01) (Table 2). Figure 2 shows that the LAT1 score is closely correlated with Ki-67 index.

Bottom Line: In 43 patients treated with melphalan and prednisolone, the overall response rate was significantly higher in the high LAT1 expression group (60.0%) than in the low LAT1 expression group (17.6%) (P = 0.03).Multivariate analysis confirmed that high expression of LAT1 was a significant prognostic factor for predicting poor overall survival independently from the International Staging System (both P = 0.01).Here, we show that the overexpression of LAT1 is significantly associated with high proliferation and poor prognosis in newly diagnosed MM patients.

View Article: PubMed Central - PubMed

Affiliation: Department of Hematology, National Hospital Organization Nishigunma Hospital, Gunma, Japan.

Show MeSH
Related in: MedlinePlus