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Anemia and the Need for Intravenous Iron Infusion after Roux-en-Y Gastric Bypass.

Kotkiewicz A, Donaldson K, Dye C, Rogers AM, Mauger D, Kong L, Eyster ME - Clin Med Insights Blood Disord (2015)

Bottom Line: Twenty-seven subjects, primarily premenopausal women, representing 8.5% of the cohort and 22% of the 122 anemic subjects, needed intravenous (IV) iron a mean of 51 months postoperatively for anemia unresponsive or refractory to oral iron.The risk for development of anemia necessitating IV iron therapy following RYGB is highest in menstruating women and continues to increase for many years, even in post-menopausal women.Well-designed prospective studies are needed to identify the incidence of iron deficiency anemia and the patient populations at increased risk for requiring IV iron replacement after RYGB surgery.

View Article: PubMed Central - PubMed

Affiliation: LVH-M Cancer Center, Bethlehem, Pennsylvania, PA, USA.

ABSTRACT
The frequency of anemia, iron deficiency, and the long-term need for IV iron following Roux-en-y gastric bypass (RYGB) surgery has not been well characterized. Three-hundred and nineteen out of 904 consecutive subjects who underwent RYGB at Penn State Hershey Medical Center from 1999 to 2006 met the inclusion criteria for a preoperative complete blood count (CBC) and at least one CBC >6 months following surgery. Cumulative incidence of anemia 7 years post procedure was 58%. Menstruation status and presence of preoperative anemia were predictive of anemia by univariate analysis and multivariable Cox regression (P = 0.0014 and 0.044, respectively). Twenty-seven subjects, primarily premenopausal women, representing 8.5% of the cohort and 22% of the 122 anemic subjects, needed intravenous (IV) iron a mean of 51 months postoperatively for anemia unresponsive or refractory to oral iron. The risk for development of anemia necessitating IV iron therapy following RYGB is highest in menstruating women and continues to increase for many years, even in post-menopausal women. Well-designed prospective studies are needed to identify the incidence of iron deficiency anemia and the patient populations at increased risk for requiring IV iron replacement after RYGB surgery.

No MeSH data available.


Related in: MedlinePlus

Kaplan–Meier cumulative event rate of anemia-free subjects by supplemental iron status after surgery. Iron post op no—; yes––; Log-rank P < 0.0001.
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f5-cmbd-8-2015-009: Kaplan–Meier cumulative event rate of anemia-free subjects by supplemental iron status after surgery. Iron post op no—; yes––; Log-rank P < 0.0001.

Mentions: One-hundred and seventy-five (55%) subjects received supplemental oral iron after surgery. However, postoperative iron replacement did not reduce the overall rate of anemia (Fig. 5).


Anemia and the Need for Intravenous Iron Infusion after Roux-en-Y Gastric Bypass.

Kotkiewicz A, Donaldson K, Dye C, Rogers AM, Mauger D, Kong L, Eyster ME - Clin Med Insights Blood Disord (2015)

Kaplan–Meier cumulative event rate of anemia-free subjects by supplemental iron status after surgery. Iron post op no—; yes––; Log-rank P < 0.0001.
© Copyright Policy - open-access
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC4462165&req=5

f5-cmbd-8-2015-009: Kaplan–Meier cumulative event rate of anemia-free subjects by supplemental iron status after surgery. Iron post op no—; yes––; Log-rank P < 0.0001.
Mentions: One-hundred and seventy-five (55%) subjects received supplemental oral iron after surgery. However, postoperative iron replacement did not reduce the overall rate of anemia (Fig. 5).

Bottom Line: Twenty-seven subjects, primarily premenopausal women, representing 8.5% of the cohort and 22% of the 122 anemic subjects, needed intravenous (IV) iron a mean of 51 months postoperatively for anemia unresponsive or refractory to oral iron.The risk for development of anemia necessitating IV iron therapy following RYGB is highest in menstruating women and continues to increase for many years, even in post-menopausal women.Well-designed prospective studies are needed to identify the incidence of iron deficiency anemia and the patient populations at increased risk for requiring IV iron replacement after RYGB surgery.

View Article: PubMed Central - PubMed

Affiliation: LVH-M Cancer Center, Bethlehem, Pennsylvania, PA, USA.

ABSTRACT
The frequency of anemia, iron deficiency, and the long-term need for IV iron following Roux-en-y gastric bypass (RYGB) surgery has not been well characterized. Three-hundred and nineteen out of 904 consecutive subjects who underwent RYGB at Penn State Hershey Medical Center from 1999 to 2006 met the inclusion criteria for a preoperative complete blood count (CBC) and at least one CBC >6 months following surgery. Cumulative incidence of anemia 7 years post procedure was 58%. Menstruation status and presence of preoperative anemia were predictive of anemia by univariate analysis and multivariable Cox regression (P = 0.0014 and 0.044, respectively). Twenty-seven subjects, primarily premenopausal women, representing 8.5% of the cohort and 22% of the 122 anemic subjects, needed intravenous (IV) iron a mean of 51 months postoperatively for anemia unresponsive or refractory to oral iron. The risk for development of anemia necessitating IV iron therapy following RYGB is highest in menstruating women and continues to increase for many years, even in post-menopausal women. Well-designed prospective studies are needed to identify the incidence of iron deficiency anemia and the patient populations at increased risk for requiring IV iron replacement after RYGB surgery.

No MeSH data available.


Related in: MedlinePlus