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Nefopam for the prevention of perioperative shivering: a meta-analysis of randomized controlled trials.

Lv M, Wang X, Qu W, Liu M, Wang Y - BMC Anesthesiol (2015)

Bottom Line: Regrettably, there is still no conclusion of the efficacy and safety of nefopam for the prevention of perioperative shivering.Outcome data was analysed by using random effect model or fixed effect model in accordance with heterogeneity.As compared with clonidine, nefopam was more efficacious in the prevention of perioperative shivering (RR 0.34; 95% CI 0.17-0.70).

View Article: PubMed Central - PubMed

Affiliation: Department of anesthesiology, Qianfo shan Hospital, Shandong University, Jinan, Shandong, China. qylvmeng@163.com.

ABSTRACT

Background: Shivering is a frequent complication following surgery and anaesthesia. A large variety of studies have been reported that nefopam may be efficacious for the prevention and treatment of perioperative shivering. Regrettably, there is still no conclusion of the efficacy and safety of nefopam for the prevention of perioperative shivering. The aim of this analysis is to evaluate the efficacy of nefopam for the prevention of perioperative shivering in patients undergoing different types of anaesthesia compared with placebo group and other active interventions.

Methods: PubMed, EMBASE, Cochrane Central Register of Control Trials were systematically searched for potentially relevant trials. Trial quality and extracted data were evaluated by two authors independently. Dichotomous data on the absence of shivering was extracted and analysed by using relative risk (RR) with 95% confidence interval (CI). Continuous outcome was abstracted and analysed by using weighted mean difference (WMD) with 95% confidence interval (CI). Outcome data was analysed by using random effect model or fixed effect model in accordance with heterogeneity.

Results: Compared with placebo, prophylactic administration of nefopam significantly reduced the risk of perioperative shivering not only in the patients under general anaesthesia but also neuraxial anaesthesia (RR 0.08; 95% CI 0.05-0.13). As compared with clonidine, nefopam was more efficacious in the prevention of perioperative shivering (RR 0.34; 95% CI 0.17-0.70). Nefopam has no influence on the extubation time (WMD 0.92; 95% CI -0.15-1.99).

Conclusion: Our analysis has demonstrated that nefopam is associated with the decrease of risk of perioperative shivering following anaesthesia without influencing the extubation time.

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Related in: MedlinePlus

The effect of nefopam on perioperative shivering under different anesthesia
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Fig5: The effect of nefopam on perioperative shivering under different anesthesia

Mentions: Subgroup analysis focused on the different methods of anaesthesia, general anaesthesia and neuraxial anaesthesia, as shown in Fig. 5.


Nefopam for the prevention of perioperative shivering: a meta-analysis of randomized controlled trials.

Lv M, Wang X, Qu W, Liu M, Wang Y - BMC Anesthesiol (2015)

The effect of nefopam on perioperative shivering under different anesthesia
© Copyright Policy - open-access
Related In: Results  -  Collection

License 1 - License 2
Show All Figures
getmorefigures.php?uid=PMC4459453&req=5

Fig5: The effect of nefopam on perioperative shivering under different anesthesia
Mentions: Subgroup analysis focused on the different methods of anaesthesia, general anaesthesia and neuraxial anaesthesia, as shown in Fig. 5.

Bottom Line: Regrettably, there is still no conclusion of the efficacy and safety of nefopam for the prevention of perioperative shivering.Outcome data was analysed by using random effect model or fixed effect model in accordance with heterogeneity.As compared with clonidine, nefopam was more efficacious in the prevention of perioperative shivering (RR 0.34; 95% CI 0.17-0.70).

View Article: PubMed Central - PubMed

Affiliation: Department of anesthesiology, Qianfo shan Hospital, Shandong University, Jinan, Shandong, China. qylvmeng@163.com.

ABSTRACT

Background: Shivering is a frequent complication following surgery and anaesthesia. A large variety of studies have been reported that nefopam may be efficacious for the prevention and treatment of perioperative shivering. Regrettably, there is still no conclusion of the efficacy and safety of nefopam for the prevention of perioperative shivering. The aim of this analysis is to evaluate the efficacy of nefopam for the prevention of perioperative shivering in patients undergoing different types of anaesthesia compared with placebo group and other active interventions.

Methods: PubMed, EMBASE, Cochrane Central Register of Control Trials were systematically searched for potentially relevant trials. Trial quality and extracted data were evaluated by two authors independently. Dichotomous data on the absence of shivering was extracted and analysed by using relative risk (RR) with 95% confidence interval (CI). Continuous outcome was abstracted and analysed by using weighted mean difference (WMD) with 95% confidence interval (CI). Outcome data was analysed by using random effect model or fixed effect model in accordance with heterogeneity.

Results: Compared with placebo, prophylactic administration of nefopam significantly reduced the risk of perioperative shivering not only in the patients under general anaesthesia but also neuraxial anaesthesia (RR 0.08; 95% CI 0.05-0.13). As compared with clonidine, nefopam was more efficacious in the prevention of perioperative shivering (RR 0.34; 95% CI 0.17-0.70). Nefopam has no influence on the extubation time (WMD 0.92; 95% CI -0.15-1.99).

Conclusion: Our analysis has demonstrated that nefopam is associated with the decrease of risk of perioperative shivering following anaesthesia without influencing the extubation time.

Show MeSH
Related in: MedlinePlus