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Maternal zinc deficiency during pregnancy elevates the risks of fetal growth restriction: a population-based birth cohort study.

Wang H, Hu YF, Hao JH, Chen YH, Su PY, Wang Y, Yu Z, Fu L, Xu YY, Zhang C, Tao FB, Xu DX - Sci Rep (2015)

Bottom Line: A nested case-control study within above cohort showed that maternal serum zinc level was lower in SGA cases as compared with controls.By contrast, maternal serum C-reactive protein, TNF-α and IL-8 levels were significantly higher in SGA cases than that of controls.Moreover, nuclear NF-κB p65 was significantly up-regulated in placentas of SGA cases as compared with controls.

View Article: PubMed Central - PubMed

Affiliation: 1] School of Public Health, Anhui Medical University, Hefei, China [2] Anhui Provincial Key Laboratory of Population Health &Aristogenics, Anhui Medical University, Hefei, China.

ABSTRACT
We investigated the association between maternal zinc level during pregnancy and the risks of low birth weight (LBW) and small for gestational age (SGA) infants in a large population-based birth cohort study. In this study, 3187 pregnant women were recruited. For serum zinc level, 2940 pregnant women were sufficient (≥56 μg/dL) and 247 deficient (<56 μg/dL). Of interest, 7.3% newborns were with LBW among subjects with low zinc level (RR: 3.48; 95% CI: 2.03, 5.96; P < 0.001). Adjusted RR for LBW was 3.41 (95% CI: 1.97, 5.91; P < 0.001) among subjects with low zinc level. Moreover, 15.0% newborns were with SGA among subjects with low zinc level (RR: 1.98; 95% CI: 1.36, 2.88; P < 0.001). Adjusted RR for SGA was 1.93 (95% CI: 1.32, 2.82; P < 0.001) among subjects with low zinc level. A nested case-control study within above cohort showed that maternal serum zinc level was lower in SGA cases as compared with controls. By contrast, maternal serum C-reactive protein, TNF-α and IL-8 levels were significantly higher in SGA cases than that of controls. Moreover, nuclear NF-κB p65 was significantly up-regulated in placentas of SGA cases as compared with controls. Taken together, maternal zinc deficiency during pregnancy elevates the risks of LBW and SGA infants.

No MeSH data available.


Related in: MedlinePlus

Serum zinc level during early gestational stage and inflammatory cytokines in maternal sera from SGA cases and controls.Serum zinc level and inflammatory cytokines during the first trimester were measured in 50 SGA cases and 100 controls. (A) Zinc. (B) CRP. (C) TNF-α. (D) IL-8. All data were expressed as means ± SEM. **P < 0.01, ***P < 0.001 as compared with controls.
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f2: Serum zinc level during early gestational stage and inflammatory cytokines in maternal sera from SGA cases and controls.Serum zinc level and inflammatory cytokines during the first trimester were measured in 50 SGA cases and 100 controls. (A) Zinc. (B) CRP. (C) TNF-α. (D) IL-8. All data were expressed as means ± SEM. **P < 0.01, ***P < 0.001 as compared with controls.

Mentions: We compared serum zinc level from SGA cases and controls. As expected, the level of serum zinc during pregnancy was lower in SGA cases as compared with controls (Fig. 2A). We then compared the levels of CRP, TNF-α and IL-8 in maternal sera from SGA cases and controls. As shown in Fig. 2B, the level of CRP in maternal sera was significantly higher in SGA cases than that of controls. In addition, the level of TNF-α and IL-8 in maternal sera was also higher in SGA cases than that of controls (Fig. 2C,D).


Maternal zinc deficiency during pregnancy elevates the risks of fetal growth restriction: a population-based birth cohort study.

Wang H, Hu YF, Hao JH, Chen YH, Su PY, Wang Y, Yu Z, Fu L, Xu YY, Zhang C, Tao FB, Xu DX - Sci Rep (2015)

Serum zinc level during early gestational stage and inflammatory cytokines in maternal sera from SGA cases and controls.Serum zinc level and inflammatory cytokines during the first trimester were measured in 50 SGA cases and 100 controls. (A) Zinc. (B) CRP. (C) TNF-α. (D) IL-8. All data were expressed as means ± SEM. **P < 0.01, ***P < 0.001 as compared with controls.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4459238&req=5

f2: Serum zinc level during early gestational stage and inflammatory cytokines in maternal sera from SGA cases and controls.Serum zinc level and inflammatory cytokines during the first trimester were measured in 50 SGA cases and 100 controls. (A) Zinc. (B) CRP. (C) TNF-α. (D) IL-8. All data were expressed as means ± SEM. **P < 0.01, ***P < 0.001 as compared with controls.
Mentions: We compared serum zinc level from SGA cases and controls. As expected, the level of serum zinc during pregnancy was lower in SGA cases as compared with controls (Fig. 2A). We then compared the levels of CRP, TNF-α and IL-8 in maternal sera from SGA cases and controls. As shown in Fig. 2B, the level of CRP in maternal sera was significantly higher in SGA cases than that of controls. In addition, the level of TNF-α and IL-8 in maternal sera was also higher in SGA cases than that of controls (Fig. 2C,D).

Bottom Line: A nested case-control study within above cohort showed that maternal serum zinc level was lower in SGA cases as compared with controls.By contrast, maternal serum C-reactive protein, TNF-α and IL-8 levels were significantly higher in SGA cases than that of controls.Moreover, nuclear NF-κB p65 was significantly up-regulated in placentas of SGA cases as compared with controls.

View Article: PubMed Central - PubMed

Affiliation: 1] School of Public Health, Anhui Medical University, Hefei, China [2] Anhui Provincial Key Laboratory of Population Health &Aristogenics, Anhui Medical University, Hefei, China.

ABSTRACT
We investigated the association between maternal zinc level during pregnancy and the risks of low birth weight (LBW) and small for gestational age (SGA) infants in a large population-based birth cohort study. In this study, 3187 pregnant women were recruited. For serum zinc level, 2940 pregnant women were sufficient (≥56 μg/dL) and 247 deficient (<56 μg/dL). Of interest, 7.3% newborns were with LBW among subjects with low zinc level (RR: 3.48; 95% CI: 2.03, 5.96; P < 0.001). Adjusted RR for LBW was 3.41 (95% CI: 1.97, 5.91; P < 0.001) among subjects with low zinc level. Moreover, 15.0% newborns were with SGA among subjects with low zinc level (RR: 1.98; 95% CI: 1.36, 2.88; P < 0.001). Adjusted RR for SGA was 1.93 (95% CI: 1.32, 2.82; P < 0.001) among subjects with low zinc level. A nested case-control study within above cohort showed that maternal serum zinc level was lower in SGA cases as compared with controls. By contrast, maternal serum C-reactive protein, TNF-α and IL-8 levels were significantly higher in SGA cases than that of controls. Moreover, nuclear NF-κB p65 was significantly up-regulated in placentas of SGA cases as compared with controls. Taken together, maternal zinc deficiency during pregnancy elevates the risks of LBW and SGA infants.

No MeSH data available.


Related in: MedlinePlus