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Disrupted resting-state attentional networks in T2DM patients.

Xia W, Wang S, Rao H, Spaeth AM, Wang P, Yang Y, Huang R, Cai R, Sun H - Sci Rep (2015)

Bottom Line: The T2DM patients exhibited decreased rsFC in the left middle frontal gyrus (MFG) and bilateral inferior parietal lobe (IPL) of the DAN, as well as the left IPL and right MFG/IFG of the VAN.In addition, the rsFC of the left MFG was inversely correlated with the Trail Making Test-B scores; the rsFC of the left IPL was positively correlated with the Digit Span Test scores but negatively correlated with HbA1c; and the rsFC in the right precuneus was positively associated with cognitive performance (without Bonferroni correction).In conclusion, T2DM affects resting-state attentional networks, which may be related to reduced attention and a hyperglycemic state.

View Article: PubMed Central - PubMed

Affiliation: 1] Department of Endocrinology, affiliated ZhongDa Hospital of Southeast University, No. 87 Dingjiaqiao Road, Nanjing, China, 210009 [2] Medical school of Southeast University, No. 87 Dingjiaqiao Road, Nanjing, China, 210009 [3] Center for functional Neuroimaging, University of Pennsylvania, 3710 Hamilton Walk, Philadelphia, PA, USA, 19104.

ABSTRACT
Although Type 2 diabetes mellitus (T2DM) is a well-recognized risk factor for dementia, the neural mechanisms that underlie cognitive impairment in T2DM remain unclear. This study uses resting-state functional magnetic resonance imaging (fMRI) to examine attention network alterations in T2DM and their relationships to impaired cognitive performance. Data-driven independent component analysis was applied to resting-state fMRI data from 38 T2DM patients and 32 healthy controls to identify the dorsal attention network (DAN) and ventral attention network (VAN). Correlations were then determined among the resting-state functional connectivity (rsFC), clinical data, and neuropsychological scores. The T2DM patients exhibited decreased rsFC in the left middle frontal gyrus (MFG) and bilateral inferior parietal lobe (IPL) of the DAN, as well as the left IPL and right MFG/IFG of the VAN. In addition, the rsFC of the left MFG was inversely correlated with the Trail Making Test-B scores; the rsFC of the left IPL was positively correlated with the Digit Span Test scores but negatively correlated with HbA1c; and the rsFC in the right precuneus was positively associated with cognitive performance (without Bonferroni correction). In conclusion, T2DM affects resting-state attentional networks, which may be related to reduced attention and a hyperglycemic state.

No MeSH data available.


Related in: MedlinePlus

Significant decreases (cold color) and increases (warm color) in the resting-state functional connectivity of the DAN(a) and VAN (b) in T2DM patients. T2DM patients displayed decreased rsFC in the right inferior frontal gyrus (IFG), left middle frontal gyrus (MFG), and bilateral inferior parietal lobe (IPL) of the DAN, as well as the left IPL and right MFG/IFG of the VAN. Thresholds were set at a corrected p < 0.05, determined using a Monte Carlo simulation. Note that the left side corresponds to the right hemisphere.
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f2: Significant decreases (cold color) and increases (warm color) in the resting-state functional connectivity of the DAN(a) and VAN (b) in T2DM patients. T2DM patients displayed decreased rsFC in the right inferior frontal gyrus (IFG), left middle frontal gyrus (MFG), and bilateral inferior parietal lobe (IPL) of the DAN, as well as the left IPL and right MFG/IFG of the VAN. Thresholds were set at a corrected p < 0.05, determined using a Monte Carlo simulation. Note that the left side corresponds to the right hemisphere.

Mentions: The one-sample t-test revealed typical significant spatial patterns of the DAN and VAN in both the controls and T2DM patients (p < 0.05, corrected; Fig. 1). Fig. 2 displays the rsFC differences in the attentional related network according to two-sample t-tests between groups. Compared with controls, T2DM patients displayed decreased rsFC in the left middle frontal gyrus (MFG) and bilateral inferior parietal lobe (IPL) of the DAN, as well as the left IPL and right MFG/IFG of the VAN (p < 0.05, corrected) (Table 3).


Disrupted resting-state attentional networks in T2DM patients.

Xia W, Wang S, Rao H, Spaeth AM, Wang P, Yang Y, Huang R, Cai R, Sun H - Sci Rep (2015)

Significant decreases (cold color) and increases (warm color) in the resting-state functional connectivity of the DAN(a) and VAN (b) in T2DM patients. T2DM patients displayed decreased rsFC in the right inferior frontal gyrus (IFG), left middle frontal gyrus (MFG), and bilateral inferior parietal lobe (IPL) of the DAN, as well as the left IPL and right MFG/IFG of the VAN. Thresholds were set at a corrected p < 0.05, determined using a Monte Carlo simulation. Note that the left side corresponds to the right hemisphere.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4459168&req=5

f2: Significant decreases (cold color) and increases (warm color) in the resting-state functional connectivity of the DAN(a) and VAN (b) in T2DM patients. T2DM patients displayed decreased rsFC in the right inferior frontal gyrus (IFG), left middle frontal gyrus (MFG), and bilateral inferior parietal lobe (IPL) of the DAN, as well as the left IPL and right MFG/IFG of the VAN. Thresholds were set at a corrected p < 0.05, determined using a Monte Carlo simulation. Note that the left side corresponds to the right hemisphere.
Mentions: The one-sample t-test revealed typical significant spatial patterns of the DAN and VAN in both the controls and T2DM patients (p < 0.05, corrected; Fig. 1). Fig. 2 displays the rsFC differences in the attentional related network according to two-sample t-tests between groups. Compared with controls, T2DM patients displayed decreased rsFC in the left middle frontal gyrus (MFG) and bilateral inferior parietal lobe (IPL) of the DAN, as well as the left IPL and right MFG/IFG of the VAN (p < 0.05, corrected) (Table 3).

Bottom Line: The T2DM patients exhibited decreased rsFC in the left middle frontal gyrus (MFG) and bilateral inferior parietal lobe (IPL) of the DAN, as well as the left IPL and right MFG/IFG of the VAN.In addition, the rsFC of the left MFG was inversely correlated with the Trail Making Test-B scores; the rsFC of the left IPL was positively correlated with the Digit Span Test scores but negatively correlated with HbA1c; and the rsFC in the right precuneus was positively associated with cognitive performance (without Bonferroni correction).In conclusion, T2DM affects resting-state attentional networks, which may be related to reduced attention and a hyperglycemic state.

View Article: PubMed Central - PubMed

Affiliation: 1] Department of Endocrinology, affiliated ZhongDa Hospital of Southeast University, No. 87 Dingjiaqiao Road, Nanjing, China, 210009 [2] Medical school of Southeast University, No. 87 Dingjiaqiao Road, Nanjing, China, 210009 [3] Center for functional Neuroimaging, University of Pennsylvania, 3710 Hamilton Walk, Philadelphia, PA, USA, 19104.

ABSTRACT
Although Type 2 diabetes mellitus (T2DM) is a well-recognized risk factor for dementia, the neural mechanisms that underlie cognitive impairment in T2DM remain unclear. This study uses resting-state functional magnetic resonance imaging (fMRI) to examine attention network alterations in T2DM and their relationships to impaired cognitive performance. Data-driven independent component analysis was applied to resting-state fMRI data from 38 T2DM patients and 32 healthy controls to identify the dorsal attention network (DAN) and ventral attention network (VAN). Correlations were then determined among the resting-state functional connectivity (rsFC), clinical data, and neuropsychological scores. The T2DM patients exhibited decreased rsFC in the left middle frontal gyrus (MFG) and bilateral inferior parietal lobe (IPL) of the DAN, as well as the left IPL and right MFG/IFG of the VAN. In addition, the rsFC of the left MFG was inversely correlated with the Trail Making Test-B scores; the rsFC of the left IPL was positively correlated with the Digit Span Test scores but negatively correlated with HbA1c; and the rsFC in the right precuneus was positively associated with cognitive performance (without Bonferroni correction). In conclusion, T2DM affects resting-state attentional networks, which may be related to reduced attention and a hyperglycemic state.

No MeSH data available.


Related in: MedlinePlus