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Intestinal obstruction: predictor of poor prognosis in colorectal carcinoma?

Mohd Suan MA, Tan WL, Soelar SA, Ismail I, Abu Hassan MR - Epidemiol Health (2015)

Bottom Line: Data pertaining to 4,501 colorectal carcinoma patients were extracted from the national colorectal registry and analysed.Survival analysis was performed using the Kaplan-Meier method.The p-values<0.05 were considered to indicate statistical significance.

View Article: PubMed Central - PubMed

Affiliation: Clinical Research Center, Sultanah Bahiyah Hospital, Kedah, Malaysia.

ABSTRACT

Objectives: The goal of this study was to assess the relationship between intestinal obstruction and the prognosis of colorectal carcinoma.

Methods: Data pertaining to 4,501 colorectal carcinoma patients were extracted from the national colorectal registry and analysed. Survival analysis was performed using the Kaplan-Meier method. The log-rank test was used to compare the survival rate between patients with intestinal obstruction and those without intestinal obstruction. The p-values<0.05 were considered to indicate statistical significance. Simple Cox proportional hazards regression analysis was used to estimate the crude hazard ratio of mortality from colorectal cancer.

Results: Intestinal obstruction was reported in more than 13% of patients. The 3-year survival rate after treatment was 48.3% (95% confidence interval [CI], 43.9 to 52.8) for patients with intestinal obstruction (n=593) and 54.9% (95% CI, 53.1 to 56.6) for patients without intestinal obstruction (n=3,908). The 5-year survival rate for patients with intestinal obstruction was 37.3% (95% CI, 31.9 to 42.8), which was lower than that of patients without intestinal obstruction (45.6%; 95% CI, 43.5 to 47.7). After adjusting the hazard ratio for other prognostic variables, intestinal obstruction had a statistically significant negative correlation with the survival rate of colorectal cancer patients, with an adjusted hazard ratio of 1.22 (p=0.008).

Conclusions: The presence of intestinal obstruction is associated with a lower survival rate among colorectal cancer patients.

No MeSH data available.


Related in: MedlinePlus

Kaplan-Meier curve of the survival of colorectal carcinoma patients with and without intestinal obstruction.
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f1-epih-37-e2015017: Kaplan-Meier curve of the survival of colorectal carcinoma patients with and without intestinal obstruction.

Mentions: The Kaplan-Meier estimates of the 3-year survival rate after treatment (Table 2, Figure 1) were 48.3% (95% confidence interval [CI], 43.9 to 52.8) for patients with intestinal obstruction (n=593) and 54.9% (95% CI, 53.1 to 56.6) for patients without intestinal obstruction (n=3,908). The 5-year survival rate for patients with intestinal obstruction was 37.3% (95% CI, 31.9 to 42.8), which was lower than that of patients without intestinal obstruction (45.6%; 95% CI, 43.5 to 47.7).The log-rank test was used to compare the survival rates of patients with intestinal obstruction and patients without intestinal obstruction, and a statistically significant difference was found (p=0.005).


Intestinal obstruction: predictor of poor prognosis in colorectal carcinoma?

Mohd Suan MA, Tan WL, Soelar SA, Ismail I, Abu Hassan MR - Epidemiol Health (2015)

Kaplan-Meier curve of the survival of colorectal carcinoma patients with and without intestinal obstruction.
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4459110&req=5

f1-epih-37-e2015017: Kaplan-Meier curve of the survival of colorectal carcinoma patients with and without intestinal obstruction.
Mentions: The Kaplan-Meier estimates of the 3-year survival rate after treatment (Table 2, Figure 1) were 48.3% (95% confidence interval [CI], 43.9 to 52.8) for patients with intestinal obstruction (n=593) and 54.9% (95% CI, 53.1 to 56.6) for patients without intestinal obstruction (n=3,908). The 5-year survival rate for patients with intestinal obstruction was 37.3% (95% CI, 31.9 to 42.8), which was lower than that of patients without intestinal obstruction (45.6%; 95% CI, 43.5 to 47.7).The log-rank test was used to compare the survival rates of patients with intestinal obstruction and patients without intestinal obstruction, and a statistically significant difference was found (p=0.005).

Bottom Line: Data pertaining to 4,501 colorectal carcinoma patients were extracted from the national colorectal registry and analysed.Survival analysis was performed using the Kaplan-Meier method.The p-values<0.05 were considered to indicate statistical significance.

View Article: PubMed Central - PubMed

Affiliation: Clinical Research Center, Sultanah Bahiyah Hospital, Kedah, Malaysia.

ABSTRACT

Objectives: The goal of this study was to assess the relationship between intestinal obstruction and the prognosis of colorectal carcinoma.

Methods: Data pertaining to 4,501 colorectal carcinoma patients were extracted from the national colorectal registry and analysed. Survival analysis was performed using the Kaplan-Meier method. The log-rank test was used to compare the survival rate between patients with intestinal obstruction and those without intestinal obstruction. The p-values<0.05 were considered to indicate statistical significance. Simple Cox proportional hazards regression analysis was used to estimate the crude hazard ratio of mortality from colorectal cancer.

Results: Intestinal obstruction was reported in more than 13% of patients. The 3-year survival rate after treatment was 48.3% (95% confidence interval [CI], 43.9 to 52.8) for patients with intestinal obstruction (n=593) and 54.9% (95% CI, 53.1 to 56.6) for patients without intestinal obstruction (n=3,908). The 5-year survival rate for patients with intestinal obstruction was 37.3% (95% CI, 31.9 to 42.8), which was lower than that of patients without intestinal obstruction (45.6%; 95% CI, 43.5 to 47.7). After adjusting the hazard ratio for other prognostic variables, intestinal obstruction had a statistically significant negative correlation with the survival rate of colorectal cancer patients, with an adjusted hazard ratio of 1.22 (p=0.008).

Conclusions: The presence of intestinal obstruction is associated with a lower survival rate among colorectal cancer patients.

No MeSH data available.


Related in: MedlinePlus