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Reconstruction of the arcuate fasciculus for surgical planning in the setting of peritumoral edema using two-tensor unscented Kalman filter tractography.

Chen Z, Tie Y, Olubiyi O, Rigolo L, Mehrtash A, Norton I, Pasternak O, Rathi Y, Golby AJ, O'Donnell LJ - Neuroimage Clin (2015)

Bottom Line: Results from the two different tractography algorithms were compared visually and quantitatively.Using single-tensor streamline tractography, the AF appeared disrupted in four patients and contained few fibers in the remaining six patients.The volume of the AF was significantly larger on two-tensor UKF than on single-tensor streamline tractography (p < 0.01).

View Article: PubMed Central - PubMed

Affiliation: Department of Neurosurgery, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA ; Department of Neurosurgery, Jinling Hospital, Southern Medical University, Nanjing, Jiangsu 210002, China.

ABSTRACT

Background: Diffusion imaging tractography is increasingly used to trace critical fiber tracts in brain tumor patients to reduce the risk of post-operative neurological deficit. However, the effects of peritumoral edema pose a challenge to conventional tractography using the standard diffusion tensor model. The aim of this study was to present a novel technique using a two-tensor unscented Kalman filter (UKF) algorithm to track the arcuate fasciculus (AF) in brain tumor patients with peritumoral edema.

Methods: Ten right-handed patients with left-sided brain tumors in the vicinity of language-related cortex and evidence of significant peritumoral edema were retrospectively selected for the study. All patients underwent 3-Tesla magnetic resonance imaging (MRI) including a diffusion-weighted dataset with 31 directions. Fiber tractography was performed using both single-tensor streamline and two-tensor UKF tractography. A two-regions-of-interest approach was applied to perform the delineation of the AF. Results from the two different tractography algorithms were compared visually and quantitatively.

Results: Using single-tensor streamline tractography, the AF appeared disrupted in four patients and contained few fibers in the remaining six patients. Two-tensor UKF tractography delineated an AF that traversed edematous brain areas in all patients. The volume of the AF was significantly larger on two-tensor UKF than on single-tensor streamline tractography (p < 0.01).

Conclusions: Two-tensor UKF tractography provides the ability to trace a larger volume AF than single-tensor streamline tractography in the setting of peritumoral edema in brain tumor patients.

No MeSH data available.


Related in: MedlinePlus

Images from patient 4. (A and C) Single-tensor streamline tractography (yellow) appears to indicate a disrupted AF, terminating in the vicinity of the peritumoral edema margin (arrow). (B and D) Two-tensor UKF tractography produces a frontotemporally arching tract running through the T2-bright area (arrow).
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f0015: Images from patient 4. (A and C) Single-tensor streamline tractography (yellow) appears to indicate a disrupted AF, terminating in the vicinity of the peritumoral edema margin (arrow). (B and D) Two-tensor UKF tractography produces a frontotemporally arching tract running through the T2-bright area (arrow).

Mentions: Fig. 3 demonstrates images from patient 4, who presented with left-sided headaches and developed word-finding difficulties. Axial thin-slice T2-weighted images showed a 3.5 cm mass lesion (green surface model) in the left lateral temporal lobe close to the temporo-parietal junction, with surrounding white matter edema extending to the posterior aspect of the left internal and external capsules. Fig. 3A shows the fiber trajectory reconstructed by single-tensor streamline tractography. This image appears to show a disrupted AF, terminating in the peritumoral edema margin in the vicinity of the supramarginal gyrus (arrow). However, two-tensor UKF tractography delineated frontotemporally arching fibers running through the T2-bright area (Fig. 3B, arrow). 3D lateral views of the results from two different methods are illustrated in Fig. 4C and D. Single-tensor streamline tractography displayed a small frontal fiber bundle (Fig. 3C) while two-tensor UKF tractography output a larger and longer fiber bundle, particularly displaying the arc around the Sylvian fissure (Fig. 3D).


Reconstruction of the arcuate fasciculus for surgical planning in the setting of peritumoral edema using two-tensor unscented Kalman filter tractography.

Chen Z, Tie Y, Olubiyi O, Rigolo L, Mehrtash A, Norton I, Pasternak O, Rathi Y, Golby AJ, O'Donnell LJ - Neuroimage Clin (2015)

Images from patient 4. (A and C) Single-tensor streamline tractography (yellow) appears to indicate a disrupted AF, terminating in the vicinity of the peritumoral edema margin (arrow). (B and D) Two-tensor UKF tractography produces a frontotemporally arching tract running through the T2-bright area (arrow).
© Copyright Policy - CC BY-NC-ND
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4459040&req=5

f0015: Images from patient 4. (A and C) Single-tensor streamline tractography (yellow) appears to indicate a disrupted AF, terminating in the vicinity of the peritumoral edema margin (arrow). (B and D) Two-tensor UKF tractography produces a frontotemporally arching tract running through the T2-bright area (arrow).
Mentions: Fig. 3 demonstrates images from patient 4, who presented with left-sided headaches and developed word-finding difficulties. Axial thin-slice T2-weighted images showed a 3.5 cm mass lesion (green surface model) in the left lateral temporal lobe close to the temporo-parietal junction, with surrounding white matter edema extending to the posterior aspect of the left internal and external capsules. Fig. 3A shows the fiber trajectory reconstructed by single-tensor streamline tractography. This image appears to show a disrupted AF, terminating in the peritumoral edema margin in the vicinity of the supramarginal gyrus (arrow). However, two-tensor UKF tractography delineated frontotemporally arching fibers running through the T2-bright area (Fig. 3B, arrow). 3D lateral views of the results from two different methods are illustrated in Fig. 4C and D. Single-tensor streamline tractography displayed a small frontal fiber bundle (Fig. 3C) while two-tensor UKF tractography output a larger and longer fiber bundle, particularly displaying the arc around the Sylvian fissure (Fig. 3D).

Bottom Line: Results from the two different tractography algorithms were compared visually and quantitatively.Using single-tensor streamline tractography, the AF appeared disrupted in four patients and contained few fibers in the remaining six patients.The volume of the AF was significantly larger on two-tensor UKF than on single-tensor streamline tractography (p < 0.01).

View Article: PubMed Central - PubMed

Affiliation: Department of Neurosurgery, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA ; Department of Neurosurgery, Jinling Hospital, Southern Medical University, Nanjing, Jiangsu 210002, China.

ABSTRACT

Background: Diffusion imaging tractography is increasingly used to trace critical fiber tracts in brain tumor patients to reduce the risk of post-operative neurological deficit. However, the effects of peritumoral edema pose a challenge to conventional tractography using the standard diffusion tensor model. The aim of this study was to present a novel technique using a two-tensor unscented Kalman filter (UKF) algorithm to track the arcuate fasciculus (AF) in brain tumor patients with peritumoral edema.

Methods: Ten right-handed patients with left-sided brain tumors in the vicinity of language-related cortex and evidence of significant peritumoral edema were retrospectively selected for the study. All patients underwent 3-Tesla magnetic resonance imaging (MRI) including a diffusion-weighted dataset with 31 directions. Fiber tractography was performed using both single-tensor streamline and two-tensor UKF tractography. A two-regions-of-interest approach was applied to perform the delineation of the AF. Results from the two different tractography algorithms were compared visually and quantitatively.

Results: Using single-tensor streamline tractography, the AF appeared disrupted in four patients and contained few fibers in the remaining six patients. Two-tensor UKF tractography delineated an AF that traversed edematous brain areas in all patients. The volume of the AF was significantly larger on two-tensor UKF than on single-tensor streamline tractography (p < 0.01).

Conclusions: Two-tensor UKF tractography provides the ability to trace a larger volume AF than single-tensor streamline tractography in the setting of peritumoral edema in brain tumor patients.

No MeSH data available.


Related in: MedlinePlus