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Modeling the response of ON and OFF retinal bipolar cells during electric stimulation.

Werginz P, Benav H, Zrenner E, Rattay F - Vision Res. (2014)

Bottom Line: Intracellular calcium increased to values up to fourfold higher in the OFF bipolar model neuron in comparison to the ON bipolar cell.Furthermore, geometric properties strongly influence the activation of bipolar cells.Monophasic, biphasic, single and repetitive pulses with similar lengths, amplitudes and polarities were applied to the two model neurons.

View Article: PubMed Central - PubMed

Affiliation: Institute for Analysis and Scientific Computing, Vienna University of Technology, 1040 Vienna, Austria.

No MeSH data available.


Related in: MedlinePlus

Stimulus paradigm used for the parametric investigation of biphasic anodic first pulses – The length of the first pulse determined the parameter x. Areas A and B were equal for each simulation. Biphasic cathodic first simulations were conducted analogously.
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f0025: Stimulus paradigm used for the parametric investigation of biphasic anodic first pulses – The length of the first pulse determined the parameter x. Areas A and B were equal for each simulation. Biphasic cathodic first simulations were conducted analogously.

Mentions: Monophasic rectangular anodic (hyperpolarizing) and cathodic (depolarizing) pulses were delivered as well as biphasic anodic- and cathodic-first stimuli, for the stimulating paradigm see Fig. 5. Also the response of the model neurons to stimulus bursts (consecutive pulses) and sinusoidal stimulation was explored.


Modeling the response of ON and OFF retinal bipolar cells during electric stimulation.

Werginz P, Benav H, Zrenner E, Rattay F - Vision Res. (2014)

Stimulus paradigm used for the parametric investigation of biphasic anodic first pulses – The length of the first pulse determined the parameter x. Areas A and B were equal for each simulation. Biphasic cathodic first simulations were conducted analogously.
© Copyright Policy - CC BY
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4457536&req=5

f0025: Stimulus paradigm used for the parametric investigation of biphasic anodic first pulses – The length of the first pulse determined the parameter x. Areas A and B were equal for each simulation. Biphasic cathodic first simulations were conducted analogously.
Mentions: Monophasic rectangular anodic (hyperpolarizing) and cathodic (depolarizing) pulses were delivered as well as biphasic anodic- and cathodic-first stimuli, for the stimulating paradigm see Fig. 5. Also the response of the model neurons to stimulus bursts (consecutive pulses) and sinusoidal stimulation was explored.

Bottom Line: Intracellular calcium increased to values up to fourfold higher in the OFF bipolar model neuron in comparison to the ON bipolar cell.Furthermore, geometric properties strongly influence the activation of bipolar cells.Monophasic, biphasic, single and repetitive pulses with similar lengths, amplitudes and polarities were applied to the two model neurons.

View Article: PubMed Central - PubMed

Affiliation: Institute for Analysis and Scientific Computing, Vienna University of Technology, 1040 Vienna, Austria.

No MeSH data available.


Related in: MedlinePlus