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A compact photometer based on metal-waveguide-capillary: application to detecting glucose of nanomolar concentration.

Bai M, Huang H, Hao J, Zhang J, Wu H, Qu B - Sci Rep (2015)

Bottom Line: Trace analysis of liquid samples has wide applications in life science and environmental monitor.In this paper, a compact and low-cost photometer based on metal-waveguide-capillary (MWC) was developed for ultra-sensitive absorbance detection.The optical-path can be greatly enhanced and much longer than the physical length of MWC, because the light scattered by the rippled and smooth metal sidewall can be confined inside the capillary regardless of the incident-angle.

View Article: PubMed Central - PubMed

Affiliation: Department of Electronic Science and Technology, Faculty of Electronic Information and Electrical Engineering, Dalian University of Technology, Dalian 116024, China.

ABSTRACT
Trace analysis of liquid samples has wide applications in life science and environmental monitor. In this paper, a compact and low-cost photometer based on metal-waveguide-capillary (MWC) was developed for ultra-sensitive absorbance detection. The optical-path can be greatly enhanced and much longer than the physical length of MWC, because the light scattered by the rippled and smooth metal sidewall can be confined inside the capillary regardless of the incident-angle. For the photometer with a 7 cm long MWC, the detection limit is improved ~3000 fold compared with that of commercial spectrophotometer with 1 cm-cuvette, owing to the novel nonlinear optical-path enhancement as well as fast sample switching, and detecting glucose of a concentration as low as 5.12 nM was realized with conventional chromogenic reagent.

No MeSH data available.


The relationship between the absorbance and concentration of the glucose samples.
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Related In: Results  -  Collection

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f11: The relationship between the absorbance and concentration of the glucose samples.

Mentions: Relationship between the absorbance and concentration was plotted in Fig. 11. In comparison with the cuvette-based spectrophotometer, a 125-fold improvement on detection limit is achieved by using the MWC-based photometer. This improvement is lower than that obtained in red-ink detection, due to the poor stability of GOD-POD reagent. The nonlinear enhancement of absorbance at low concentrations was also observed.


A compact photometer based on metal-waveguide-capillary: application to detecting glucose of nanomolar concentration.

Bai M, Huang H, Hao J, Zhang J, Wu H, Qu B - Sci Rep (2015)

The relationship between the absorbance and concentration of the glucose samples.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4447070&req=5

f11: The relationship between the absorbance and concentration of the glucose samples.
Mentions: Relationship between the absorbance and concentration was plotted in Fig. 11. In comparison with the cuvette-based spectrophotometer, a 125-fold improvement on detection limit is achieved by using the MWC-based photometer. This improvement is lower than that obtained in red-ink detection, due to the poor stability of GOD-POD reagent. The nonlinear enhancement of absorbance at low concentrations was also observed.

Bottom Line: Trace analysis of liquid samples has wide applications in life science and environmental monitor.In this paper, a compact and low-cost photometer based on metal-waveguide-capillary (MWC) was developed for ultra-sensitive absorbance detection.The optical-path can be greatly enhanced and much longer than the physical length of MWC, because the light scattered by the rippled and smooth metal sidewall can be confined inside the capillary regardless of the incident-angle.

View Article: PubMed Central - PubMed

Affiliation: Department of Electronic Science and Technology, Faculty of Electronic Information and Electrical Engineering, Dalian University of Technology, Dalian 116024, China.

ABSTRACT
Trace analysis of liquid samples has wide applications in life science and environmental monitor. In this paper, a compact and low-cost photometer based on metal-waveguide-capillary (MWC) was developed for ultra-sensitive absorbance detection. The optical-path can be greatly enhanced and much longer than the physical length of MWC, because the light scattered by the rippled and smooth metal sidewall can be confined inside the capillary regardless of the incident-angle. For the photometer with a 7 cm long MWC, the detection limit is improved ~3000 fold compared with that of commercial spectrophotometer with 1 cm-cuvette, owing to the novel nonlinear optical-path enhancement as well as fast sample switching, and detecting glucose of a concentration as low as 5.12 nM was realized with conventional chromogenic reagent.

No MeSH data available.