Loop flexibility in human telomeric quadruplex small-molecule complexes.
Bottom Line: Sugar conformation and backbone angles have also been examined and trends highlighted.One particular loop class has been found to be most prevalent.Implications for in particular, rational drug design, are discussed.
Affiliation: UCL School of Pharmacy, University College London, 29-39 Brunswick Square, London WC1N 1AX, UK.Show MeSH
Related in: MedlinePlus
Mentions: (A) View of the human telomeric quadruplex native and ligand complex crystal structures, with nucleic acids drawn in stick form and ligands in surface representation. Metal ions (potassiums) are shown as purple spheres. Individual loops are highlighted with sticks in single colours. The colour coding corresponds to the more detailed view of each loop type shown in Figure 2. (B) Structures of individual ligands, shown with the PDB IDs for the structures in which they occur.
Affiliation: UCL School of Pharmacy, University College London, 29-39 Brunswick Square, London WC1N 1AX, UK.