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Thicker temporal cortex associates with a developmental trajectory for psychopathic traits in adolescents.

Yang Y, Wang P, Baker LA, Narr KL, Joshi SH, Hafzalla G, Raine A, Thompson PM - PLoS ONE (2015)

Bottom Line: Specifically, at age 14, higher psychopathic scores were correlated with thinner cortex in the middle frontal gyrus, particularly in females, and thicker cortex in the superior temporal gyrus, middle temporal gyrus, and parahippocampal gyrus, particularly in males.Longitudinally, individual rates of change in psychopathic tendency over time were correlated with thicker cortex in the superior temporal gyrus, middle temporal gyrus, inferior temporal gyrus, parahippocampal gyrus, and posterior cingulate gyrus, particularly in males.Findings suggest that abnormal cortical thickness may reflect a delay in brain maturation, resulting in disturbances in frontal and temporal functioning such as impulsivity, sensation-seeking, and emotional dysregulation in adolescents.

View Article: PubMed Central - PubMed

Affiliation: Department of Pediatrics, Children's Hospital Los Angeles, University of Southern California, Los Angeles, California, United States of America.

ABSTRACT
Psychopathy is a clinical condition characterized by a failure in normal social interaction and morality. Recent studies have begun to reveal brain structural abnormalities associated with psychopathic tendencies in children. However, little is known about whether variations in brain morphology are linked to the developmental trajectory of psychopathic traits over time. In this study, structural magnetic resonance imaging (sMRI) data from 108 14-year-old adolescents with no history of substance abuse (54 males and 54 females) were examined to detect cortical thickness variations associated with psychopathic traits and individual rates of change in psychopathic traits from ages 9 to 18. We found cortical thickness abnormalities to correlate with psychopathic traits both cross-sectionally and longitudinally. Specifically, at age 14, higher psychopathic scores were correlated with thinner cortex in the middle frontal gyrus, particularly in females, and thicker cortex in the superior temporal gyrus, middle temporal gyrus, and parahippocampal gyrus, particularly in males. Longitudinally, individual rates of change in psychopathic tendency over time were correlated with thicker cortex in the superior temporal gyrus, middle temporal gyrus, inferior temporal gyrus, parahippocampal gyrus, and posterior cingulate gyrus, particularly in males. Findings suggest that abnormal cortical thickness may reflect a delay in brain maturation, resulting in disturbances in frontal and temporal functioning such as impulsivity, sensation-seeking, and emotional dysregulation in adolescents. Thus, findings provide initial evidence supporting that abnormal cortical thickness may serve as a biomarker for the development of psychopathic propensity in adolescents.

No MeSH data available.


Related in: MedlinePlus

Concurrent Correlations between Cortical Thickness and Psychopathy Scores in Males and Females.FDR-corrected P value maps show significant correlations between cortical thickness and psychopathic traits at 14 years old in males and females with the corresponding uncorrected beta maps show the direction of the correlation.
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pone.0127025.g004: Concurrent Correlations between Cortical Thickness and Psychopathy Scores in Males and Females.FDR-corrected P value maps show significant correlations between cortical thickness and psychopathic traits at 14 years old in males and females with the corresponding uncorrected beta maps show the direction of the correlation.

Mentions: In our post-hoc analyses for gender-specific effects (Fig 4), we found higher psychopathy scores in males to correlate significantly with thicker cortex in the bilateral middle temporal gyri, right superior temporal gyrus, left inferior temporal gyrus, left medial orbitofrontal gyrus, right supramarginal gyrus, bilateral paracentral gyri, left precuneus gyrus, bilateral precentral and postcentral gyri, and bilateral lateral occipital gyri. For females, higher psychopathy scores were correlated with thinner cortex in the bilateral middle frontal gyri, left superior frontal gyrus, right medial orbitofrontal gyrus, left insula, right isthmus cingulate gyrus, and thicker cortex in the bilateral superior temporal gyri.


Thicker temporal cortex associates with a developmental trajectory for psychopathic traits in adolescents.

Yang Y, Wang P, Baker LA, Narr KL, Joshi SH, Hafzalla G, Raine A, Thompson PM - PLoS ONE (2015)

Concurrent Correlations between Cortical Thickness and Psychopathy Scores in Males and Females.FDR-corrected P value maps show significant correlations between cortical thickness and psychopathic traits at 14 years old in males and females with the corresponding uncorrected beta maps show the direction of the correlation.
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4446360&req=5

pone.0127025.g004: Concurrent Correlations between Cortical Thickness and Psychopathy Scores in Males and Females.FDR-corrected P value maps show significant correlations between cortical thickness and psychopathic traits at 14 years old in males and females with the corresponding uncorrected beta maps show the direction of the correlation.
Mentions: In our post-hoc analyses for gender-specific effects (Fig 4), we found higher psychopathy scores in males to correlate significantly with thicker cortex in the bilateral middle temporal gyri, right superior temporal gyrus, left inferior temporal gyrus, left medial orbitofrontal gyrus, right supramarginal gyrus, bilateral paracentral gyri, left precuneus gyrus, bilateral precentral and postcentral gyri, and bilateral lateral occipital gyri. For females, higher psychopathy scores were correlated with thinner cortex in the bilateral middle frontal gyri, left superior frontal gyrus, right medial orbitofrontal gyrus, left insula, right isthmus cingulate gyrus, and thicker cortex in the bilateral superior temporal gyri.

Bottom Line: Specifically, at age 14, higher psychopathic scores were correlated with thinner cortex in the middle frontal gyrus, particularly in females, and thicker cortex in the superior temporal gyrus, middle temporal gyrus, and parahippocampal gyrus, particularly in males.Longitudinally, individual rates of change in psychopathic tendency over time were correlated with thicker cortex in the superior temporal gyrus, middle temporal gyrus, inferior temporal gyrus, parahippocampal gyrus, and posterior cingulate gyrus, particularly in males.Findings suggest that abnormal cortical thickness may reflect a delay in brain maturation, resulting in disturbances in frontal and temporal functioning such as impulsivity, sensation-seeking, and emotional dysregulation in adolescents.

View Article: PubMed Central - PubMed

Affiliation: Department of Pediatrics, Children's Hospital Los Angeles, University of Southern California, Los Angeles, California, United States of America.

ABSTRACT
Psychopathy is a clinical condition characterized by a failure in normal social interaction and morality. Recent studies have begun to reveal brain structural abnormalities associated with psychopathic tendencies in children. However, little is known about whether variations in brain morphology are linked to the developmental trajectory of psychopathic traits over time. In this study, structural magnetic resonance imaging (sMRI) data from 108 14-year-old adolescents with no history of substance abuse (54 males and 54 females) were examined to detect cortical thickness variations associated with psychopathic traits and individual rates of change in psychopathic traits from ages 9 to 18. We found cortical thickness abnormalities to correlate with psychopathic traits both cross-sectionally and longitudinally. Specifically, at age 14, higher psychopathic scores were correlated with thinner cortex in the middle frontal gyrus, particularly in females, and thicker cortex in the superior temporal gyrus, middle temporal gyrus, and parahippocampal gyrus, particularly in males. Longitudinally, individual rates of change in psychopathic tendency over time were correlated with thicker cortex in the superior temporal gyrus, middle temporal gyrus, inferior temporal gyrus, parahippocampal gyrus, and posterior cingulate gyrus, particularly in males. Findings suggest that abnormal cortical thickness may reflect a delay in brain maturation, resulting in disturbances in frontal and temporal functioning such as impulsivity, sensation-seeking, and emotional dysregulation in adolescents. Thus, findings provide initial evidence supporting that abnormal cortical thickness may serve as a biomarker for the development of psychopathic propensity in adolescents.

No MeSH data available.


Related in: MedlinePlus