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Chondroprotective effects of Salubrinal in a mouse model of osteoarthritis.

Hamamura K, Nishimura A, Iino T, Takigawa S, Sudo A, Yokota H - Bone Joint Res (2015)

Bottom Line: Although Guanabenz elevates the phosphorylation level of eIF2α, it did not suppress the progression of OA.Administration of Salubrinal has chondroprotective effects in arthritic joints.Cite this article: Bone Joint Res 2015;4:84-92.

View Article: PubMed Central - PubMed

Affiliation: Indiana University, Purdue University, Indianapolis, 723 West Michigan Street, Indianapolis, Indiana 46202, USA.

No MeSH data available.


Related in: MedlinePlus

Graphs showing the effects of Salubrinal on subchondral bone and synovium, with a) thickness ofsubchondral bone in the medial femoral condyle (MFC) (left) and medial tibial plateau (MTP) (right)(three weeks top row, six weeks bottom row) and b) synovial score for three-week (left) and six-week(right) samples. *p < 0.05; **p < 0.01.
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Related In: Results  -  Collection


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f4: Graphs showing the effects of Salubrinal on subchondral bone and synovium, with a) thickness ofsubchondral bone in the medial femoral condyle (MFC) (left) and medial tibial plateau (MTP) (right)(three weeks top row, six weeks bottom row) and b) synovial score for three-week (left) and six-week(right) samples. *p < 0.05; **p < 0.01.


Chondroprotective effects of Salubrinal in a mouse model of osteoarthritis.

Hamamura K, Nishimura A, Iino T, Takigawa S, Sudo A, Yokota H - Bone Joint Res (2015)

Graphs showing the effects of Salubrinal on subchondral bone and synovium, with a) thickness ofsubchondral bone in the medial femoral condyle (MFC) (left) and medial tibial plateau (MTP) (right)(three weeks top row, six weeks bottom row) and b) synovial score for three-week (left) and six-week(right) samples. *p < 0.05; **p < 0.01.
© Copyright Policy - open-access
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC4443296&req=5

f4: Graphs showing the effects of Salubrinal on subchondral bone and synovium, with a) thickness ofsubchondral bone in the medial femoral condyle (MFC) (left) and medial tibial plateau (MTP) (right)(three weeks top row, six weeks bottom row) and b) synovial score for three-week (left) and six-week(right) samples. *p < 0.05; **p < 0.01.
Bottom Line: Although Guanabenz elevates the phosphorylation level of eIF2α, it did not suppress the progression of OA.Administration of Salubrinal has chondroprotective effects in arthritic joints.Cite this article: Bone Joint Res 2015;4:84-92.

View Article: PubMed Central - PubMed

Affiliation: Indiana University, Purdue University, Indianapolis, 723 West Michigan Street, Indianapolis, Indiana 46202, USA.

No MeSH data available.


Related in: MedlinePlus