Limits...
Editorial comment to "The value of percentage free prostate-specific antigen (PSA) in the detection of prostate cancer among patients with intermediate levels of total PSA (4.0-10.0 ng/mL) in Nigeria" and Reply by authors.

Elabbady A, Ezenwa EV - Arab J Urol (2012)

View Article: PubMed Central - PubMed

Affiliation: Urology Department, University of Alexandria, Egypt.

AUTOMATICALLY GENERATED EXCERPT
Please rate it.

The authors evaluated the value of the percentage free PSA (% fPSA) in 105 Nigerian patients with a palpably benign prostate gland and intermediate total PSA levels (4.0–10 ng/mL) for detecting prostate cancer... However, six of the patients with a % fPSA level of <40% had no cancer... The authors concluded that the best threshold for % fPSA in the studied population was <40%, with a sensitivity of 100%, specificity of 93.4% and a positive predictive value of 70%... This is different from the value reported previously of a threshold of ⩽25% fPSA for patients with PSA levels of 4.0–10.0 ng/mL and where a TRUS biopsy was used, and more extended biopsy protocols adopted... Digitally directed transrectal biopsies are no longer the standard, as the exact path of the needle, the exact site of the biopsy and the depth of penetration cannot be guaranteed except under TRUS guidance... The aim of the study was to determine a threshold value for % fPSA for prostate biopsy in African patients with an intermediate total PSA level, and to compare this threshold with that of <25% obtained from Caucasian patients... The digitally directed biopsy was chosen because it was the only available method for biopsy in this population, as TRUS was not available, and hence the need for this comparison... However, the threshold % fPSA value in this study was quite close to that recorded by Fowler et al. in a study involving a significant percentage of African-American patients, using TRUS guidance, thereby suggesting that the lower threshold might not be suitable for a black population, where the burden of the disease is quite high... Moreover, Catalona et al. in their large multicentre study found no significant difference when the % fPSA was correlated with various prostate volume ranges, and so a single threshold value, irrespective of prostate volume, was recommended in that study.

No MeSH data available.


© Copyright Policy - CC BY-NC-ND
Related In: Results  -  Collection

License
getmorefigures.php?uid=PMC4442942&req=5


Editorial comment to "The value of percentage free prostate-specific antigen (PSA) in the detection of prostate cancer among patients with intermediate levels of total PSA (4.0-10.0 ng/mL) in Nigeria" and Reply by authors.

Elabbady A, Ezenwa EV - Arab J Urol (2012)

© Copyright Policy - CC BY-NC-ND
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4442942&req=5

View Article: PubMed Central - PubMed

Affiliation: Urology Department, University of Alexandria, Egypt.

AUTOMATICALLY GENERATED EXCERPT
Please rate it.

The authors evaluated the value of the percentage free PSA (% fPSA) in 105 Nigerian patients with a palpably benign prostate gland and intermediate total PSA levels (4.0–10 ng/mL) for detecting prostate cancer... However, six of the patients with a % fPSA level of <40% had no cancer... The authors concluded that the best threshold for % fPSA in the studied population was <40%, with a sensitivity of 100%, specificity of 93.4% and a positive predictive value of 70%... This is different from the value reported previously of a threshold of ⩽25% fPSA for patients with PSA levels of 4.0–10.0 ng/mL and where a TRUS biopsy was used, and more extended biopsy protocols adopted... Digitally directed transrectal biopsies are no longer the standard, as the exact path of the needle, the exact site of the biopsy and the depth of penetration cannot be guaranteed except under TRUS guidance... The aim of the study was to determine a threshold value for % fPSA for prostate biopsy in African patients with an intermediate total PSA level, and to compare this threshold with that of <25% obtained from Caucasian patients... The digitally directed biopsy was chosen because it was the only available method for biopsy in this population, as TRUS was not available, and hence the need for this comparison... However, the threshold % fPSA value in this study was quite close to that recorded by Fowler et al. in a study involving a significant percentage of African-American patients, using TRUS guidance, thereby suggesting that the lower threshold might not be suitable for a black population, where the burden of the disease is quite high... Moreover, Catalona et al. in their large multicentre study found no significant difference when the % fPSA was correlated with various prostate volume ranges, and so a single threshold value, irrespective of prostate volume, was recommended in that study.

No MeSH data available.