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Recurrence pattern in patients with locally advanced renal cell carcinoma: The implications of clinicopathological variables.

Sameh WM, Hashad MM, Eid AA, Abou Yousif TA, Atta MA - Arab J Urol (2012)

Bottom Line: RFS rates at 1, 2, and 5 years were 50%, 43% and 34%, respectively, while the median RFS was 23.7 months.After multivariate analysis, T-stage, nuclear grade and sarcomatoid differentiation retained their power as independent predictors of RFS (P = 0.032, <0.001 and 0.003, respectively).Considering these variables in the postoperative surveillance protocols and in the need for a multimodal therapeutic approach is highly recommended.

View Article: PubMed Central - PubMed

Affiliation: Department of Urology, Faculty of Medicine, University of Alexandria, Egypt.

ABSTRACT

Objectives: Recurrence rates for patients with locally advanced renal cell carcinoma (LARCC) remain high. To date the predictors of recurrence in those patients remain controversial. The aim of the present study was to assess the relapse pattern in those patients and identify predictors for recurrence.

Patients and methods: We evaluated retrospectively 112 consecutive patients who underwent surgery for LARCC (T3-T4N0M0) between January 2000 and December 2010. Clinical and pathological data were collected from hospital medical records and compiled into a computerized database. Studied variables were age, mode of presentation, Tumour-Node-Metastasis (TNM) stage, Fuhrman nuclear grade, histological subtype, tumour size, venous thrombus level, collecting-system invasion and sarcomatoid differentiation. Recurrence-free survival (RFS) was estimated using the Kaplan-Meier method. Univariate and multivariate analyses were conducted.

Results: Patients were followed for a mean and median follow-up of 33 and 24 months, respectively, after surgery. During the follow-up, recurrences (distant and/or local) were recorded in 58 patients, representing 52% of the cohort. The mean and median times to recurrence were 25 and 13 months, respectively. Sites of recurrence were multiple in 36 patients (62%), lung only in 14 (24%), and local in eight (14%). RFS rates at 1, 2, and 5 years were 50%, 43% and 34%, respectively, while the median RFS was 23.7 months. Using univariate analysis, RFS after nephrectomy was significantly shorter in patients aged <70 years, symptomatic at presentation, with larger tumours, higher nuclear grade, collecting-system invasion, and/or sarcomatoid differentiation. After multivariate analysis, T-stage, nuclear grade and sarcomatoid differentiation retained their power as independent predictors of RFS (P = 0.032, <0.001 and 0.003, respectively).

Conclusions: For patients with LARCC, T-stage, grade and sarcomatoid differentiation independently dictate the risk of tumour recurrence. Considering these variables in the postoperative surveillance protocols and in the need for a multimodal therapeutic approach is highly recommended.

No MeSH data available.


Related in: MedlinePlus

The CSS probability curve after thrombectomy, stratified by the level of thrombus.
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f0015: The CSS probability curve after thrombectomy, stratified by the level of thrombus.

Mentions: Patients with thrombus limited to the renal vein (level 0) had a significantly longer RFS than those with caval thrombus (levels I–IV). The 5-year RFS for patients with caval thrombus was 16%, compared with 53% for those with renal vein thrombus (P = 0.028, log-rank; Fig. 3). Patients with caval thrombus of different levels had a comparable RFS.


Recurrence pattern in patients with locally advanced renal cell carcinoma: The implications of clinicopathological variables.

Sameh WM, Hashad MM, Eid AA, Abou Yousif TA, Atta MA - Arab J Urol (2012)

The CSS probability curve after thrombectomy, stratified by the level of thrombus.
© Copyright Policy - CC BY-NC-ND
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4442897&req=5

f0015: The CSS probability curve after thrombectomy, stratified by the level of thrombus.
Mentions: Patients with thrombus limited to the renal vein (level 0) had a significantly longer RFS than those with caval thrombus (levels I–IV). The 5-year RFS for patients with caval thrombus was 16%, compared with 53% for those with renal vein thrombus (P = 0.028, log-rank; Fig. 3). Patients with caval thrombus of different levels had a comparable RFS.

Bottom Line: RFS rates at 1, 2, and 5 years were 50%, 43% and 34%, respectively, while the median RFS was 23.7 months.After multivariate analysis, T-stage, nuclear grade and sarcomatoid differentiation retained their power as independent predictors of RFS (P = 0.032, <0.001 and 0.003, respectively).Considering these variables in the postoperative surveillance protocols and in the need for a multimodal therapeutic approach is highly recommended.

View Article: PubMed Central - PubMed

Affiliation: Department of Urology, Faculty of Medicine, University of Alexandria, Egypt.

ABSTRACT

Objectives: Recurrence rates for patients with locally advanced renal cell carcinoma (LARCC) remain high. To date the predictors of recurrence in those patients remain controversial. The aim of the present study was to assess the relapse pattern in those patients and identify predictors for recurrence.

Patients and methods: We evaluated retrospectively 112 consecutive patients who underwent surgery for LARCC (T3-T4N0M0) between January 2000 and December 2010. Clinical and pathological data were collected from hospital medical records and compiled into a computerized database. Studied variables were age, mode of presentation, Tumour-Node-Metastasis (TNM) stage, Fuhrman nuclear grade, histological subtype, tumour size, venous thrombus level, collecting-system invasion and sarcomatoid differentiation. Recurrence-free survival (RFS) was estimated using the Kaplan-Meier method. Univariate and multivariate analyses were conducted.

Results: Patients were followed for a mean and median follow-up of 33 and 24 months, respectively, after surgery. During the follow-up, recurrences (distant and/or local) were recorded in 58 patients, representing 52% of the cohort. The mean and median times to recurrence were 25 and 13 months, respectively. Sites of recurrence were multiple in 36 patients (62%), lung only in 14 (24%), and local in eight (14%). RFS rates at 1, 2, and 5 years were 50%, 43% and 34%, respectively, while the median RFS was 23.7 months. Using univariate analysis, RFS after nephrectomy was significantly shorter in patients aged <70 years, symptomatic at presentation, with larger tumours, higher nuclear grade, collecting-system invasion, and/or sarcomatoid differentiation. After multivariate analysis, T-stage, nuclear grade and sarcomatoid differentiation retained their power as independent predictors of RFS (P = 0.032, <0.001 and 0.003, respectively).

Conclusions: For patients with LARCC, T-stage, grade and sarcomatoid differentiation independently dictate the risk of tumour recurrence. Considering these variables in the postoperative surveillance protocols and in the need for a multimodal therapeutic approach is highly recommended.

No MeSH data available.


Related in: MedlinePlus