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Beneficial effect of cyproheptadine on body mass index in undernourished children: a randomized controlled trial.

Najib K, Moghtaderi M, Karamizadeh Z, Fallahzadeh E - Iran J Pediatr (2014)

Bottom Line: Cyproheptadine hydrochloride (CH) is a first-generation antihistamine which is used as an appetite stimulant.Mean weight gain after eight weeks was 0.11 kg in the control group and 0.60 kg in the CH group.There were no significant differences in changes of weight and height velocity across the study between CH-treated and control group at the end of study.

View Article: PubMed Central - PubMed

Affiliation: Neonatalogy Research Center, ; Department of Pediatrics.

ABSTRACT

Objective: Cyproheptadine hydrochloride (CH) is a first-generation antihistamine which is used as an appetite stimulant. This study was designed to identify the role of CH therapy on weight gain, linear growth and body mass index in children with mild to moderate undernutrition.

Methods: Eighty-nine patients were enrolled. The present randomized, double-blinded controlled trial included 77 evaluable patients, aged 24-64 months with undernutrition. The patients were randomized to receive cyproheptadine with multivitamin, or multivitamin over a period of four weeks. The weight, height and body mass index were measured at the baseline, four weeks after intervention and four weeks after discontinuation.

Findings: A significant higher body mass index was observed among CH-treated patients after 8 weeks intervention with cyproheptadine compared with the control group (P<0.041). Mean weight gain after eight weeks was 0.11 kg in the control group and 0.60 kg in the CH group. There were no significant differences in changes of weight and height velocity across the study between CH-treated and control group at the end of study.

Conclusion: In our study, cyproheptadine promotes increase in body mass index in children with mild to moderate undernutrition after four weeks treatment.

No MeSH data available.


Related in: MedlinePlus

Weight, height and body mass index in cypro-treated and control groups before, 4 weeks after intervention and 1 month after discontinuation of cyproheptadine.
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Figure 2: Weight, height and body mass index in cypro-treated and control groups before, 4 weeks after intervention and 1 month after discontinuation of cyproheptadine.

Mentions: In our study, mean weight gain after eight weeks was 0.11 kg in the control group and 0.60 kg in the CH group. Compared to baseline status, the result of average weight gain and linear growth after two-months (4 weeks CH therapy and 4 weeks CH after its discontinuation) were not significantly different between the two groups (P=0.83) (Table 2). BMI increased 0.15 kg/m2 in the placebo group and 0.83 kg/m2 in the intervention group (P<0.041) (Fig. 2).


Beneficial effect of cyproheptadine on body mass index in undernourished children: a randomized controlled trial.

Najib K, Moghtaderi M, Karamizadeh Z, Fallahzadeh E - Iran J Pediatr (2014)

Weight, height and body mass index in cypro-treated and control groups before, 4 weeks after intervention and 1 month after discontinuation of cyproheptadine.
© Copyright Policy
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC4442838&req=5

Figure 2: Weight, height and body mass index in cypro-treated and control groups before, 4 weeks after intervention and 1 month after discontinuation of cyproheptadine.
Mentions: In our study, mean weight gain after eight weeks was 0.11 kg in the control group and 0.60 kg in the CH group. Compared to baseline status, the result of average weight gain and linear growth after two-months (4 weeks CH therapy and 4 weeks CH after its discontinuation) were not significantly different between the two groups (P=0.83) (Table 2). BMI increased 0.15 kg/m2 in the placebo group and 0.83 kg/m2 in the intervention group (P<0.041) (Fig. 2).

Bottom Line: Cyproheptadine hydrochloride (CH) is a first-generation antihistamine which is used as an appetite stimulant.Mean weight gain after eight weeks was 0.11 kg in the control group and 0.60 kg in the CH group.There were no significant differences in changes of weight and height velocity across the study between CH-treated and control group at the end of study.

View Article: PubMed Central - PubMed

Affiliation: Neonatalogy Research Center, ; Department of Pediatrics.

ABSTRACT

Objective: Cyproheptadine hydrochloride (CH) is a first-generation antihistamine which is used as an appetite stimulant. This study was designed to identify the role of CH therapy on weight gain, linear growth and body mass index in children with mild to moderate undernutrition.

Methods: Eighty-nine patients were enrolled. The present randomized, double-blinded controlled trial included 77 evaluable patients, aged 24-64 months with undernutrition. The patients were randomized to receive cyproheptadine with multivitamin, or multivitamin over a period of four weeks. The weight, height and body mass index were measured at the baseline, four weeks after intervention and four weeks after discontinuation.

Findings: A significant higher body mass index was observed among CH-treated patients after 8 weeks intervention with cyproheptadine compared with the control group (P<0.041). Mean weight gain after eight weeks was 0.11 kg in the control group and 0.60 kg in the CH group. There were no significant differences in changes of weight and height velocity across the study between CH-treated and control group at the end of study.

Conclusion: In our study, cyproheptadine promotes increase in body mass index in children with mild to moderate undernutrition after four weeks treatment.

No MeSH data available.


Related in: MedlinePlus