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Prevalence of Celiac Disease in Children with Autoimmune Hepatitis and vice versa.

Najafi M, Sadjadei N, Eftekhari K, Khodadad A, Motamed F, Fallahi GH, Farahmand F - Iran J Pediatr (2014)

Bottom Line: Autoimmune liver disease is sometimes associated with latent celiac disease.Serological screening for celiac disease should be routinely done in patients with abnormal serum aminotransferases, particularly those with chronic liver disease.On the other hand, celiac disease is often accompanied by other autoimmune diseases, including autoimmune hepatitis.

View Article: PubMed Central - PubMed

Affiliation: Department of Pediatrics, ; Children's Medical Center, Pediatrics Center of Excellence.

ABSTRACT

Objective: Celiac disease is an autoimmune disorder in which the risk of autoimmune liver disease is high. Autoimmune hepatitis is a chronic and progressive entity and the risk of its being associated with other autoimmune disorders such as celiac disease is high also. The aim of this study was to determine the prevalence of celiac disease in patients with autoimmune hepatitis and vice versa.

Methods: In a cross-sectional study children with autoimmune hepatitis underwent serological screening and endoscopy for celiac disease. In patients with celiac disease, serum aminotransferases were measured and, if abnormal, autoantibodies related to autoimmune hepatitis were checked and needle liver biopsy was performed.

Findings: Of the 96 patients, 64 had autoimmune hepatitis and 32 celiac disease. Among patients with autoimmune hepatitis only three (4.7%) were compatible with celiac disease. In the group of patients with celiac disease, autoimmune hepatitis was confirmed in four (12.5%) cases. We consider important to state that 3.1% of this group had celiac hepatitis.

Conclusion: Autoimmune liver disease is sometimes associated with latent celiac disease. Serological screening for celiac disease should be routinely done in patients with abnormal serum aminotransferases, particularly those with chronic liver disease. On the other hand, celiac disease is often accompanied by other autoimmune diseases, including autoimmune hepatitis.

No MeSH data available.


Related in: MedlinePlus

Steps to follow patients with both celiac disease and autoimmune hepatitisTTG: tissue transglutaminase antibody; AST: aspartate aminotransferase; ALT: alanine aminotransferase
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Related In: Results  -  Collection


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Figure 1: Steps to follow patients with both celiac disease and autoimmune hepatitisTTG: tissue transglutaminase antibody; AST: aspartate aminotransferase; ALT: alanine aminotransferase

Mentions: Fig. 1 depicts the steps followed in order to identify patients with both celiac disease and autoimmune hepatitis.


Prevalence of Celiac Disease in Children with Autoimmune Hepatitis and vice versa.

Najafi M, Sadjadei N, Eftekhari K, Khodadad A, Motamed F, Fallahi GH, Farahmand F - Iran J Pediatr (2014)

Steps to follow patients with both celiac disease and autoimmune hepatitisTTG: tissue transglutaminase antibody; AST: aspartate aminotransferase; ALT: alanine aminotransferase
© Copyright Policy
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC4442834&req=5

Figure 1: Steps to follow patients with both celiac disease and autoimmune hepatitisTTG: tissue transglutaminase antibody; AST: aspartate aminotransferase; ALT: alanine aminotransferase
Mentions: Fig. 1 depicts the steps followed in order to identify patients with both celiac disease and autoimmune hepatitis.

Bottom Line: Autoimmune liver disease is sometimes associated with latent celiac disease.Serological screening for celiac disease should be routinely done in patients with abnormal serum aminotransferases, particularly those with chronic liver disease.On the other hand, celiac disease is often accompanied by other autoimmune diseases, including autoimmune hepatitis.

View Article: PubMed Central - PubMed

Affiliation: Department of Pediatrics, ; Children's Medical Center, Pediatrics Center of Excellence.

ABSTRACT

Objective: Celiac disease is an autoimmune disorder in which the risk of autoimmune liver disease is high. Autoimmune hepatitis is a chronic and progressive entity and the risk of its being associated with other autoimmune disorders such as celiac disease is high also. The aim of this study was to determine the prevalence of celiac disease in patients with autoimmune hepatitis and vice versa.

Methods: In a cross-sectional study children with autoimmune hepatitis underwent serological screening and endoscopy for celiac disease. In patients with celiac disease, serum aminotransferases were measured and, if abnormal, autoantibodies related to autoimmune hepatitis were checked and needle liver biopsy was performed.

Findings: Of the 96 patients, 64 had autoimmune hepatitis and 32 celiac disease. Among patients with autoimmune hepatitis only three (4.7%) were compatible with celiac disease. In the group of patients with celiac disease, autoimmune hepatitis was confirmed in four (12.5%) cases. We consider important to state that 3.1% of this group had celiac hepatitis.

Conclusion: Autoimmune liver disease is sometimes associated with latent celiac disease. Serological screening for celiac disease should be routinely done in patients with abnormal serum aminotransferases, particularly those with chronic liver disease. On the other hand, celiac disease is often accompanied by other autoimmune diseases, including autoimmune hepatitis.

No MeSH data available.


Related in: MedlinePlus