A Systematic Meta-analysis of Immune Signatures in Patients With Acute Chikungunya Virus Infection.
Bottom Line: However, studies in different patient cohorts have revealed that disease manifestations vary in frequency.Our findings revealed a specific pattern of clinical presentations of joint-specific arthralgia from this CHIKV cohort.More importantly, we identified an immune mediator signature dominated by proinflammatory cytokines, which include interferon α and γ and interleukin 2, 2R, 6, 7, 12, 15, 17, and 18, across different patient cohorts of CHIKV load associated with arthralgia.
Affiliation: Singapore Immunology Network, Agency for Science, Technology and Research (A*STAR), Biopolis.Show MeSH
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Mentions: Of the 14 studies identified, 5 were excluded from the meta-analysis because their data could not be extracted for analysis: in 1 study, the results from the cytokine assay were presented as optical density readings and could not be computed into concentration values ; another study contained data from only a single patient . To overcome the lack of immune mediator profiles from non-CHIKV controls in this study, we used the data from healthy controls in a previously published study  as a reference to perform the analysis. A heat map was generated to provide an overall view of the expression profiles of all immune mediators analyzed in the 12 studies, together with data from the current Sri Lankan patient cohort. The immune mediators were segregated according to their functions as proinflammatory cytokines (Figure 3A), anti-inflammatory cytokines (Figure 3B), chemokines (Figure 4A), and growth factors (Figure 4B).Figure 3.
Affiliation: Singapore Immunology Network, Agency for Science, Technology and Research (A*STAR), Biopolis.