A Systematic Meta-analysis of Immune Signatures in Patients With Acute Chikungunya Virus Infection.
Bottom Line: However, studies in different patient cohorts have revealed that disease manifestations vary in frequency.Our findings revealed a specific pattern of clinical presentations of joint-specific arthralgia from this CHIKV cohort.More importantly, we identified an immune mediator signature dominated by proinflammatory cytokines, which include interferon α and γ and interleukin 2, 2R, 6, 7, 12, 15, 17, and 18, across different patient cohorts of CHIKV load associated with arthralgia.
Affiliation: Singapore Immunology Network, Agency for Science, Technology and Research (A*STAR), Biopolis.Show MeSH
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Mentions: Using a 30-plex microbead immunoassay, we have shown elsewhere that interleukin 1Ra (IL-1Ra), interleukin 2R (IL-2R), interleukin 5, IL-6, interleukin 7 (IL-7), interleukin 8 (IL-8), interleukin 10 (IL-10), interleukin 12 (IL-12), interleukin 15 (IL-15), IFN-α, MCP-1, and interferon gamma-induced protein 10 (IP-10) levels were significantly elevated during the acute phase of CHIKV infection in 2 distinct Singaporean patient cohorts [24, 30]. Hence, we sought to characterize the immune mediator profiles of acute serum samples collected from one of the Sri Lankan cohorts, focusing on the CHIKV PCR-positive group (n = 71) for subsequent analysis. A 2-way hierarchical clustering was performed to provide qualitative analysis of the immune mediator expression profiles from each individual in the HVL and LVL groups (Supplementary Figure 2). We found that levels of IL-1Ra, eotaxin, MCP-1, and IFN-α were significantly elevated in the HVL group compared with the LVL group (Figure 2A–D), whereas the level of IL-8 was significantly lower in the HVL group (Figure 2E).Figure 2.
Affiliation: Singapore Immunology Network, Agency for Science, Technology and Research (A*STAR), Biopolis.