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Influence of Triazine Herbicide Exposure on Guppies (Poecilia sphenops) Aromatase Activities, Altered Sex Steroid Concentration and Vitellogenin Induction.

Vasanth S, Arul G, Karthikeyeni S, Kumar TS, Vignesh V, Manimegalai M, Bupesh G, Thirumurugan R, Subramanian P - Indian J Pharm Sci (2015 Mar-Apr)

Bottom Line: There are limited studies have revealed that the effects of atrazine on sex steroids hormones, vitellogenin and induction of aromatase, gonadosomatic index and hepatosomatic index.In this study, juvenile Poecilia sphenops fish was exposed to three different (0.83, 1.25 and 2.5 ppm) concentration of atrazine for 100 d.The low level of the atrazine show estrogenic effect in males, as determined by a shortage of testosterone induction.

View Article: PubMed Central - PubMed

Affiliation: Laboratory of Aquabiotics/Nanoscience, Department of Animal Science, School of Life Sciences, Bharathidasan University, Tiruchirappalli-620 024, India.

ABSTRACT
Atrazine, a herbicide is one the most toxic and sustaining pollutants in aquatic environment. It is detectable in surface water and in underground sources of drinking water. Many studies indicate that atrazine might be a potent endocrine disrupting xenobiotic. There are limited studies have revealed that the effects of atrazine on sex steroids hormones, vitellogenin and induction of aromatase, gonadosomatic index and hepatosomatic index. In this study, juvenile Poecilia sphenops fish was exposed to three different (0.83, 1.25 and 2.5 ppm) concentration of atrazine for 100 d. Changes in plasma and gonadal content and concentrations of sex steroids and vitellogenin protein in poecilia sphenops under laboratory conditions were assessed. The low level of the atrazine show estrogenic effect in males, as determined by a shortage of testosterone induction. Present study suggests that low induction of plasma vitellogenin and aromatase in male fish become suitable biomarkers of exposure to estrogenic chemicals.

No MeSH data available.


Related in: MedlinePlus

Concentration of plasma testosterone in male and female Poecilia sphenops.Concentration of plasma testosterone in male and female Poecilia sphenops exposed to 0.83, 1.25 and 2.25 ppm of atrazine, each value is mean±SEM of 5 determinations. Control, 0.83ppm, 1.25ppm, 2.5ppm.
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Figure 1: Concentration of plasma testosterone in male and female Poecilia sphenops.Concentration of plasma testosterone in male and female Poecilia sphenops exposed to 0.83, 1.25 and 2.25 ppm of atrazine, each value is mean±SEM of 5 determinations. Control, 0.83ppm, 1.25ppm, 2.5ppm.

Mentions: Both male and female Poecilia sphenops had detectable concentrations of T and E2 in their plasma and gonads. The atrazine treated male fish showed a significant (P<0.05) reduction in plasma T concentrations (fig. 1) and a significant (P<0.05) increase in plasma E2 concentrations (fig. 2) compared to control male fish. Plasma concentrations of T in control males ranged between 17.503±0.813 and 19.374±0.246 ng/ml over the study period. At the highest concentrations of atrazine exposure to fish, there was a reduction in plasma content of T at all sampling points (P<0.05). In control female fish, mean concentrations of testosterone in the ovary were lower than in the plasma. In control females, plasma T concentrations were lower to that of males (3.320 to 13.763 ng/ml). Although a gradual decrease in plasma T from 17.503±0.813 to 12.383±0.233 ng/ml in male fish. The atrazine exposed fish testis showed (fig. 3) a significant (P<0.05) reduction in T concentration when compared to control testis.


Influence of Triazine Herbicide Exposure on Guppies (Poecilia sphenops) Aromatase Activities, Altered Sex Steroid Concentration and Vitellogenin Induction.

Vasanth S, Arul G, Karthikeyeni S, Kumar TS, Vignesh V, Manimegalai M, Bupesh G, Thirumurugan R, Subramanian P - Indian J Pharm Sci (2015 Mar-Apr)

Concentration of plasma testosterone in male and female Poecilia sphenops.Concentration of plasma testosterone in male and female Poecilia sphenops exposed to 0.83, 1.25 and 2.25 ppm of atrazine, each value is mean±SEM of 5 determinations. Control, 0.83ppm, 1.25ppm, 2.5ppm.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4442463&req=5

Figure 1: Concentration of plasma testosterone in male and female Poecilia sphenops.Concentration of plasma testosterone in male and female Poecilia sphenops exposed to 0.83, 1.25 and 2.25 ppm of atrazine, each value is mean±SEM of 5 determinations. Control, 0.83ppm, 1.25ppm, 2.5ppm.
Mentions: Both male and female Poecilia sphenops had detectable concentrations of T and E2 in their plasma and gonads. The atrazine treated male fish showed a significant (P<0.05) reduction in plasma T concentrations (fig. 1) and a significant (P<0.05) increase in plasma E2 concentrations (fig. 2) compared to control male fish. Plasma concentrations of T in control males ranged between 17.503±0.813 and 19.374±0.246 ng/ml over the study period. At the highest concentrations of atrazine exposure to fish, there was a reduction in plasma content of T at all sampling points (P<0.05). In control female fish, mean concentrations of testosterone in the ovary were lower than in the plasma. In control females, plasma T concentrations were lower to that of males (3.320 to 13.763 ng/ml). Although a gradual decrease in plasma T from 17.503±0.813 to 12.383±0.233 ng/ml in male fish. The atrazine exposed fish testis showed (fig. 3) a significant (P<0.05) reduction in T concentration when compared to control testis.

Bottom Line: There are limited studies have revealed that the effects of atrazine on sex steroids hormones, vitellogenin and induction of aromatase, gonadosomatic index and hepatosomatic index.In this study, juvenile Poecilia sphenops fish was exposed to three different (0.83, 1.25 and 2.5 ppm) concentration of atrazine for 100 d.The low level of the atrazine show estrogenic effect in males, as determined by a shortage of testosterone induction.

View Article: PubMed Central - PubMed

Affiliation: Laboratory of Aquabiotics/Nanoscience, Department of Animal Science, School of Life Sciences, Bharathidasan University, Tiruchirappalli-620 024, India.

ABSTRACT
Atrazine, a herbicide is one the most toxic and sustaining pollutants in aquatic environment. It is detectable in surface water and in underground sources of drinking water. Many studies indicate that atrazine might be a potent endocrine disrupting xenobiotic. There are limited studies have revealed that the effects of atrazine on sex steroids hormones, vitellogenin and induction of aromatase, gonadosomatic index and hepatosomatic index. In this study, juvenile Poecilia sphenops fish was exposed to three different (0.83, 1.25 and 2.5 ppm) concentration of atrazine for 100 d. Changes in plasma and gonadal content and concentrations of sex steroids and vitellogenin protein in poecilia sphenops under laboratory conditions were assessed. The low level of the atrazine show estrogenic effect in males, as determined by a shortage of testosterone induction. Present study suggests that low induction of plasma vitellogenin and aromatase in male fish become suitable biomarkers of exposure to estrogenic chemicals.

No MeSH data available.


Related in: MedlinePlus