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Multiple sclerosis course and clinical outcomes in patients with comorbid asthma: a survey study.

Manouchehrinia A, Edwards LJ, Roshanisefat H, Tench CR, Constantinescu CS - BMJ Open (2015)

Bottom Line: To determine if comorbid asthma is associated with accumulation of multiple sclerosis (MS)-related impairment and disability.We did not observe a significant association between having asthma and the risk of reaching EDSS scores 4.0 and 6.0 (HR: 1.29, 95% CI 0.93 to 1.77, and HR: 1.33, 95% CI 0.93 to 1.89, respectively) after controlling for confounders.Although we did not observe significant association between comorbid asthma and physical disability in MS, it seems that the two conditions influence one another.

View Article: PubMed Central - PubMed

Affiliation: Division of Clinical Neuroscience, Clinical Neurology Research Group, University of Nottingham, Queen's Medical Centre, Nottingham, UK Department of Clinical Neuroscience, Karolinska Institute, Stockholm, Sweden.

No MeSH data available.


Related in: MedlinePlus

A box and whisker diagram illustrate median and IQR of mean overall Multiple Sclerosis Impact Scale 29 (MSIS-29), Physical MSIS-29 and Psychological scores.
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BMJOPEN2015007806F2: A box and whisker diagram illustrate median and IQR of mean overall Multiple Sclerosis Impact Scale 29 (MSIS-29), Physical MSIS-29 and Psychological scores.

Mentions: We did not observe any significant association between having asthma and overall MSIS-29 score (coefficient: 0.67, 95% CI −10.47 to 11.83, p=0.9) and MSIS-29 physical scale (coefficient: 0.41, 95% CI −7.56 to 8.39, p=0.91). However, patients with asthma had significantly higher level of psychological impairment as measured by MSIS-29 psychological scale (coefficient: 4.57, 95% CI 1.23 to 7.90, p=0.007; figure 2).


Multiple sclerosis course and clinical outcomes in patients with comorbid asthma: a survey study.

Manouchehrinia A, Edwards LJ, Roshanisefat H, Tench CR, Constantinescu CS - BMJ Open (2015)

A box and whisker diagram illustrate median and IQR of mean overall Multiple Sclerosis Impact Scale 29 (MSIS-29), Physical MSIS-29 and Psychological scores.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4442191&req=5

BMJOPEN2015007806F2: A box and whisker diagram illustrate median and IQR of mean overall Multiple Sclerosis Impact Scale 29 (MSIS-29), Physical MSIS-29 and Psychological scores.
Mentions: We did not observe any significant association between having asthma and overall MSIS-29 score (coefficient: 0.67, 95% CI −10.47 to 11.83, p=0.9) and MSIS-29 physical scale (coefficient: 0.41, 95% CI −7.56 to 8.39, p=0.91). However, patients with asthma had significantly higher level of psychological impairment as measured by MSIS-29 psychological scale (coefficient: 4.57, 95% CI 1.23 to 7.90, p=0.007; figure 2).

Bottom Line: To determine if comorbid asthma is associated with accumulation of multiple sclerosis (MS)-related impairment and disability.We did not observe a significant association between having asthma and the risk of reaching EDSS scores 4.0 and 6.0 (HR: 1.29, 95% CI 0.93 to 1.77, and HR: 1.33, 95% CI 0.93 to 1.89, respectively) after controlling for confounders.Although we did not observe significant association between comorbid asthma and physical disability in MS, it seems that the two conditions influence one another.

View Article: PubMed Central - PubMed

Affiliation: Division of Clinical Neuroscience, Clinical Neurology Research Group, University of Nottingham, Queen's Medical Centre, Nottingham, UK Department of Clinical Neuroscience, Karolinska Institute, Stockholm, Sweden.

No MeSH data available.


Related in: MedlinePlus