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High-intensity statin therapy in patients with chronic kidney disease: a systematic review and meta-analysis.

Yan YL, Qiu B, Wang J, Deng SB, Wu L, Jing XD, Du JL, Liu YJ, She Q - BMJ Open (2015)

Bottom Line: High-intensity statin therapy could effectively reduce the risk of stroke in patients with CKD.Moreover, it is hard to draw conclusions on the safety assessment of intensive statin treatment in this particular population.More studies are needed to credibly evaluate the effects of high-intensity statin therapy in patients with CKD.

View Article: PubMed Central - PubMed

Affiliation: Department of Cardiology, The Second Affiliated Hospital of Chongqing Medical University, Chongqing, China.

No MeSH data available.


Related in: MedlinePlus

Forest plots for efficacy evaluation of intensive statin therapy for patients with CKD: all-cause mortality (A), stroke (B), myocardial infarction (C), heart failure (D), change of eGFR (E). CI, confidence intervals; M-H, Mantel-Haenszel; RR, relative risk.
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BMJOPEN2014006886F03: Forest plots for efficacy evaluation of intensive statin therapy for patients with CKD: all-cause mortality (A), stroke (B), myocardial infarction (C), heart failure (D), change of eGFR (E). CI, confidence intervals; M-H, Mantel-Haenszel; RR, relative risk.

Mentions: Data on all-cause mortality were available in 9393 patients from five studies. As shown in figure 3A, a total of 730 patients died during the follow-up period. Pooled analysis showed that there was a point estimate consistent with reduced all-cause mortality but with a CI that marginally included no effect (RR 0.85, 95% CI 0.67 to 1.09).


High-intensity statin therapy in patients with chronic kidney disease: a systematic review and meta-analysis.

Yan YL, Qiu B, Wang J, Deng SB, Wu L, Jing XD, Du JL, Liu YJ, She Q - BMJ Open (2015)

Forest plots for efficacy evaluation of intensive statin therapy for patients with CKD: all-cause mortality (A), stroke (B), myocardial infarction (C), heart failure (D), change of eGFR (E). CI, confidence intervals; M-H, Mantel-Haenszel; RR, relative risk.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4442158&req=5

BMJOPEN2014006886F03: Forest plots for efficacy evaluation of intensive statin therapy for patients with CKD: all-cause mortality (A), stroke (B), myocardial infarction (C), heart failure (D), change of eGFR (E). CI, confidence intervals; M-H, Mantel-Haenszel; RR, relative risk.
Mentions: Data on all-cause mortality were available in 9393 patients from five studies. As shown in figure 3A, a total of 730 patients died during the follow-up period. Pooled analysis showed that there was a point estimate consistent with reduced all-cause mortality but with a CI that marginally included no effect (RR 0.85, 95% CI 0.67 to 1.09).

Bottom Line: High-intensity statin therapy could effectively reduce the risk of stroke in patients with CKD.Moreover, it is hard to draw conclusions on the safety assessment of intensive statin treatment in this particular population.More studies are needed to credibly evaluate the effects of high-intensity statin therapy in patients with CKD.

View Article: PubMed Central - PubMed

Affiliation: Department of Cardiology, The Second Affiliated Hospital of Chongqing Medical University, Chongqing, China.

No MeSH data available.


Related in: MedlinePlus