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Occurrence of taraxerol and taraxasterol in medicinal plants.

Sharma K, Zafar R - Pharmacogn Rev (2015 Jan-Jun)

Bottom Line: Indian soil germinates thousands of medicinal drugs that are cultivated with a purpose to obtain a novel drug.As it is a well-established fact that the structural analogs with greater pharmacological activity and fewer side-effects may be generated by the molecular modification of the functional groups of such lead compounds.Various treatment modalities have been prescribed, along with conventional and non-conventional medicine but due to their adverse effects and dissatisfaction among users, these treatments are not satisfactory enough to give relief to patients.

View Article: PubMed Central - PubMed

Affiliation: Department of Pharmaceutical Sciences, Faculty of Pharmacy, Jamia Hamdard, New Delhi, India.

ABSTRACT
Indian soil germinates thousands of medicinal drugs that are cultivated with a purpose to obtain a novel drug. As it is a well-established fact that the structural analogs with greater pharmacological activity and fewer side-effects may be generated by the molecular modification of the functional groups of such lead compounds. This review throws light on two natural triterpenes - Taraxerol and Taraxasterol which have many important pharmacological actions including anti-cancer activity, their chemistry, biosynthesis aspects, and possible use of these compounds as drugs in treatment of cancer. A silent crisis persists in cancer treatment in developing countries, and it is intensifying every year. Although at least 50-60% of cancer victims can benefit from radiotherapy that destroys cancerous tumors, but search for the paramount therapy which will prove to be inexpensive with minimal side effects still persists. Various treatment modalities have been prescribed, along with conventional and non-conventional medicine but due to their adverse effects and dissatisfaction among users, these treatments are not satisfactory enough to give relief to patients. Hence, this review sparks the occurrence of Taraxerol (VI) and Taraxasterol (VII) in nature, so that the natural godowns may be harvested to obtain these potent compounds for novel drug development as well as discusses limitations of these lead compounds progressing clinical trials.

No MeSH data available.


Related in: MedlinePlus

(a) Structure of Taraxerol (3β)-D-Friedoolean-14-en- 3ol) (b) Structure of Taraxasterol (3β, 18α, 19α)-Urs- 20(30)-en-3-ol)
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Figure 2: (a) Structure of Taraxerol (3β)-D-Friedoolean-14-en- 3ol) (b) Structure of Taraxasterol (3β, 18α, 19α)-Urs- 20(30)-en-3-ol)

Mentions: The CAS name of Taraxerol, Figure 2a is (3b)- D-Friedoolean-14-en-3-ol. Its additional names include isoolean-14-en-3b-ol, skimmiol, alnulin, tiliadin. Its molecular formula is C30H50O and molecular weight is 426.72. Its melting point is 282-285°C. Its structure was given by Beaton et al.[3] The CAS name of Taraxasterol, Figure 2b is (3b, 18a, 19a)-Urs-20 (30)-en-3-ol. Its molecular formula is C30H50O and molecular weight is 426.72 same as Taraxerol. Its structure and configuration was reported by Ames et al.[4] The insecticidally inactive substance pyrethrol from pyrethrum flowers has been identified as taraxasterol.[5] Both Taraxerol and Taraxasterol were investigated by high-performance liquid chromatography (HPLC) using methanol containing 0.1% phosphoric acid.[6] A simple and precise high-performance thin layer chromatography (HPTLC) method has been developed for estimation of Taraxerol with hexane and ethyl acetate (80:20 v/v), using visualizing agent anisaldehyde sulphuric acid, and scanning of plate was done at 420 nm. The system was found to give compact spots for Taraxerol (Rf 0.53).[7]


Occurrence of taraxerol and taraxasterol in medicinal plants.

Sharma K, Zafar R - Pharmacogn Rev (2015 Jan-Jun)

(a) Structure of Taraxerol (3β)-D-Friedoolean-14-en- 3ol) (b) Structure of Taraxasterol (3β, 18α, 19α)-Urs- 20(30)-en-3-ol)
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4441157&req=5

Figure 2: (a) Structure of Taraxerol (3β)-D-Friedoolean-14-en- 3ol) (b) Structure of Taraxasterol (3β, 18α, 19α)-Urs- 20(30)-en-3-ol)
Mentions: The CAS name of Taraxerol, Figure 2a is (3b)- D-Friedoolean-14-en-3-ol. Its additional names include isoolean-14-en-3b-ol, skimmiol, alnulin, tiliadin. Its molecular formula is C30H50O and molecular weight is 426.72. Its melting point is 282-285°C. Its structure was given by Beaton et al.[3] The CAS name of Taraxasterol, Figure 2b is (3b, 18a, 19a)-Urs-20 (30)-en-3-ol. Its molecular formula is C30H50O and molecular weight is 426.72 same as Taraxerol. Its structure and configuration was reported by Ames et al.[4] The insecticidally inactive substance pyrethrol from pyrethrum flowers has been identified as taraxasterol.[5] Both Taraxerol and Taraxasterol were investigated by high-performance liquid chromatography (HPLC) using methanol containing 0.1% phosphoric acid.[6] A simple and precise high-performance thin layer chromatography (HPTLC) method has been developed for estimation of Taraxerol with hexane and ethyl acetate (80:20 v/v), using visualizing agent anisaldehyde sulphuric acid, and scanning of plate was done at 420 nm. The system was found to give compact spots for Taraxerol (Rf 0.53).[7]

Bottom Line: Indian soil germinates thousands of medicinal drugs that are cultivated with a purpose to obtain a novel drug.As it is a well-established fact that the structural analogs with greater pharmacological activity and fewer side-effects may be generated by the molecular modification of the functional groups of such lead compounds.Various treatment modalities have been prescribed, along with conventional and non-conventional medicine but due to their adverse effects and dissatisfaction among users, these treatments are not satisfactory enough to give relief to patients.

View Article: PubMed Central - PubMed

Affiliation: Department of Pharmaceutical Sciences, Faculty of Pharmacy, Jamia Hamdard, New Delhi, India.

ABSTRACT
Indian soil germinates thousands of medicinal drugs that are cultivated with a purpose to obtain a novel drug. As it is a well-established fact that the structural analogs with greater pharmacological activity and fewer side-effects may be generated by the molecular modification of the functional groups of such lead compounds. This review throws light on two natural triterpenes - Taraxerol and Taraxasterol which have many important pharmacological actions including anti-cancer activity, their chemistry, biosynthesis aspects, and possible use of these compounds as drugs in treatment of cancer. A silent crisis persists in cancer treatment in developing countries, and it is intensifying every year. Although at least 50-60% of cancer victims can benefit from radiotherapy that destroys cancerous tumors, but search for the paramount therapy which will prove to be inexpensive with minimal side effects still persists. Various treatment modalities have been prescribed, along with conventional and non-conventional medicine but due to their adverse effects and dissatisfaction among users, these treatments are not satisfactory enough to give relief to patients. Hence, this review sparks the occurrence of Taraxerol (VI) and Taraxasterol (VII) in nature, so that the natural godowns may be harvested to obtain these potent compounds for novel drug development as well as discusses limitations of these lead compounds progressing clinical trials.

No MeSH data available.


Related in: MedlinePlus