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Cucurbitacins - An insight into medicinal leads from nature.

Kaushik U, Aeri V, Mir SR - Pharmacogn Rev (2015 Jan-Jun)

Bottom Line: Cucurbitacins which are structurally diverse triterpenes found in the members of Cucurbitaceae and several other plant families possess immense pharmacological potential.Research focused on these unattended medicinal leads from the nature can prove to be of immense significance in generating scientifically validated data with regard to their efficacy and possible role in various diseases.This review is aimed to provide an insight into the chemical nature and medicinal potential of these compounds exploring their proposed mode of action, probable molecular targets and to have an outlook on future directions of their use as medicinal agents.

View Article: PubMed Central - PubMed

Affiliation: Department of Pharmacognosy and Phytochemistry, Phytochemistry Research Laboratory, Faculty of Pharmacy, New Delhi, India.

ABSTRACT
Cucurbitacins which are structurally diverse triterpenes found in the members of Cucurbitaceae and several other plant families possess immense pharmacological potential. This diverse group of compounds may prove to be important lead molecules for future research. Research focused on these unattended medicinal leads from the nature can prove to be of immense significance in generating scientifically validated data with regard to their efficacy and possible role in various diseases. This review is aimed to provide an insight into the chemical nature and medicinal potential of these compounds exploring their proposed mode of action, probable molecular targets and to have an outlook on future directions of their use as medicinal agents.

No MeSH data available.


Occurrence of Cucurbitacins in various plant families
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Figure 1: Occurrence of Cucurbitacins in various plant families

Mentions: Cucurbitacins are found in many cucurbitaceous plants. They are most common in species of the Bryonia, Cucumis, Cucurbita, Luffa, Echinocystis, Lagenaria and Citrullus. The plants of genera Momordica contain a special group of Cucurbitacins called momordicosides. The level of Cucurbitacins varies between tissues. They may be concentrated in fruits and roots of mature plants. In fruits where Cucurbitacins are produced, their highest concentration is achieved on maturity. Seeds generally contain very low concentration of Cucurbitacins. Cucurbitacin producing plants have also been identified outside the cucurbitaceae in the members of Scrophulariaceae, Begoniaceae, Primulaceae, Liliaceae, Tropaeolaceae and Rosaceae. The seeds of certain cruciferous plants, like Iberis species and Lepidium sativum also contain cucurbitacins.[4] It is reported that Cucurbitacins are formed in situ and are not transported to other parts of the plant.[5] The distribution of Cucurbitacins among various families of plant kingdom has been depicted in [Figure 1].


Cucurbitacins - An insight into medicinal leads from nature.

Kaushik U, Aeri V, Mir SR - Pharmacogn Rev (2015 Jan-Jun)

Occurrence of Cucurbitacins in various plant families
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4441156&req=5

Figure 1: Occurrence of Cucurbitacins in various plant families
Mentions: Cucurbitacins are found in many cucurbitaceous plants. They are most common in species of the Bryonia, Cucumis, Cucurbita, Luffa, Echinocystis, Lagenaria and Citrullus. The plants of genera Momordica contain a special group of Cucurbitacins called momordicosides. The level of Cucurbitacins varies between tissues. They may be concentrated in fruits and roots of mature plants. In fruits where Cucurbitacins are produced, their highest concentration is achieved on maturity. Seeds generally contain very low concentration of Cucurbitacins. Cucurbitacin producing plants have also been identified outside the cucurbitaceae in the members of Scrophulariaceae, Begoniaceae, Primulaceae, Liliaceae, Tropaeolaceae and Rosaceae. The seeds of certain cruciferous plants, like Iberis species and Lepidium sativum also contain cucurbitacins.[4] It is reported that Cucurbitacins are formed in situ and are not transported to other parts of the plant.[5] The distribution of Cucurbitacins among various families of plant kingdom has been depicted in [Figure 1].

Bottom Line: Cucurbitacins which are structurally diverse triterpenes found in the members of Cucurbitaceae and several other plant families possess immense pharmacological potential.Research focused on these unattended medicinal leads from the nature can prove to be of immense significance in generating scientifically validated data with regard to their efficacy and possible role in various diseases.This review is aimed to provide an insight into the chemical nature and medicinal potential of these compounds exploring their proposed mode of action, probable molecular targets and to have an outlook on future directions of their use as medicinal agents.

View Article: PubMed Central - PubMed

Affiliation: Department of Pharmacognosy and Phytochemistry, Phytochemistry Research Laboratory, Faculty of Pharmacy, New Delhi, India.

ABSTRACT
Cucurbitacins which are structurally diverse triterpenes found in the members of Cucurbitaceae and several other plant families possess immense pharmacological potential. This diverse group of compounds may prove to be important lead molecules for future research. Research focused on these unattended medicinal leads from the nature can prove to be of immense significance in generating scientifically validated data with regard to their efficacy and possible role in various diseases. This review is aimed to provide an insight into the chemical nature and medicinal potential of these compounds exploring their proposed mode of action, probable molecular targets and to have an outlook on future directions of their use as medicinal agents.

No MeSH data available.