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An in-vitro-in-vivo model for the transdermal delivery of cholecalciferol for the purposes of rodent management.

Davies J, Ingham A - Int J Pharm (2015)

Bottom Line: The natural selection of anticoagulant resistant rats has resulted in a need for an alternative to anticoagulant rodenticides which differs in both active ingredient and in the method of dosing.A 1 ml dose of 50/50 (v/v) DMSO/ethanol containing 15% (v/v) PEG 200 and 20% (w/v) cholecalciferol was judged as 'sufficiently effective' in line with the European Union's Biocidal Products Regulation (No. 528/2012) during in-vivo studies.This dose was found to cause 100% mortality in a rat population in 64.4h (± 22h).

View Article: PubMed Central - PubMed

Affiliation: School of Life and Health Sciences, Aston University, Aston Triangle, Birmingham B4 7ET, UK.

No MeSH data available.


Related in: MedlinePlus

Formulation humaneness as recorded with the distress scoring chart and weight. Mean values ± SD (n = 5). Formulations contained indicated amounts of cholecalciferol in 50/50 (v/v) DMSO/ethanol co-solvent containing 15% (v/v) PEG 200.
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fig0045: Formulation humaneness as recorded with the distress scoring chart and weight. Mean values ± SD (n = 5). Formulations contained indicated amounts of cholecalciferol in 50/50 (v/v) DMSO/ethanol co-solvent containing 15% (v/v) PEG 200.

Mentions: Fig. 9 shows the distress scoring chart and animal weight for the efficacy evaluation and negative control. The negative control showed no changes in behaviour, coupled with an increase in weight suggesting that food and water intake was healthy. The 20% (w/v) cholecalciferol concentration exhibited significant changes in behaviour, however only minor changes were observed during the first day followed by a quick increase in distress as recorded within the distress scoring chart.


An in-vitro-in-vivo model for the transdermal delivery of cholecalciferol for the purposes of rodent management.

Davies J, Ingham A - Int J Pharm (2015)

Formulation humaneness as recorded with the distress scoring chart and weight. Mean values ± SD (n = 5). Formulations contained indicated amounts of cholecalciferol in 50/50 (v/v) DMSO/ethanol co-solvent containing 15% (v/v) PEG 200.
© Copyright Policy - CC BY-NC-ND
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4441109&req=5

fig0045: Formulation humaneness as recorded with the distress scoring chart and weight. Mean values ± SD (n = 5). Formulations contained indicated amounts of cholecalciferol in 50/50 (v/v) DMSO/ethanol co-solvent containing 15% (v/v) PEG 200.
Mentions: Fig. 9 shows the distress scoring chart and animal weight for the efficacy evaluation and negative control. The negative control showed no changes in behaviour, coupled with an increase in weight suggesting that food and water intake was healthy. The 20% (w/v) cholecalciferol concentration exhibited significant changes in behaviour, however only minor changes were observed during the first day followed by a quick increase in distress as recorded within the distress scoring chart.

Bottom Line: The natural selection of anticoagulant resistant rats has resulted in a need for an alternative to anticoagulant rodenticides which differs in both active ingredient and in the method of dosing.A 1 ml dose of 50/50 (v/v) DMSO/ethanol containing 15% (v/v) PEG 200 and 20% (w/v) cholecalciferol was judged as 'sufficiently effective' in line with the European Union's Biocidal Products Regulation (No. 528/2012) during in-vivo studies.This dose was found to cause 100% mortality in a rat population in 64.4h (± 22h).

View Article: PubMed Central - PubMed

Affiliation: School of Life and Health Sciences, Aston University, Aston Triangle, Birmingham B4 7ET, UK.

No MeSH data available.


Related in: MedlinePlus