Limits...
An in-vitro-in-vivo model for the transdermal delivery of cholecalciferol for the purposes of rodent management.

Davies J, Ingham A - Int J Pharm (2015)

Bottom Line: The natural selection of anticoagulant resistant rats has resulted in a need for an alternative to anticoagulant rodenticides which differs in both active ingredient and in the method of dosing.A 1 ml dose of 50/50 (v/v) DMSO/ethanol containing 15% (v/v) PEG 200 and 20% (w/v) cholecalciferol was judged as 'sufficiently effective' in line with the European Union's Biocidal Products Regulation (No. 528/2012) during in-vivo studies.This dose was found to cause 100% mortality in a rat population in 64.4h (± 22h).

View Article: PubMed Central - PubMed

Affiliation: School of Life and Health Sciences, Aston University, Aston Triangle, Birmingham B4 7ET, UK.

No MeSH data available.


Related in: MedlinePlus

Cholecalciferol permeation profiles obtained with the diffusion cell in-vitro model. A volume of 5 ml was used for the donor phase. Dashed lines represent the linear regression for the line of best fit. Mean values ± SD (n = 3).
© Copyright Policy - CC BY-NC-ND
Related In: Results  -  Collection

License
getmorefigures.php?uid=PMC4441109&req=5

fig0020: Cholecalciferol permeation profiles obtained with the diffusion cell in-vitro model. A volume of 5 ml was used for the donor phase. Dashed lines represent the linear regression for the line of best fit. Mean values ± SD (n = 3).

Mentions: Fig. 4 shows the permeation of cholecalciferol through a synthetic membrane using the diffusion cell arrangement. Based on the results from the cellulose tubing in-vitro model, formulations containing high percentages of DMSO were investigated, while ethanol formulations served as comparators. A combination of cholecalciferol concentrations and chemical penetration enhancers were used.


An in-vitro-in-vivo model for the transdermal delivery of cholecalciferol for the purposes of rodent management.

Davies J, Ingham A - Int J Pharm (2015)

Cholecalciferol permeation profiles obtained with the diffusion cell in-vitro model. A volume of 5 ml was used for the donor phase. Dashed lines represent the linear regression for the line of best fit. Mean values ± SD (n = 3).
© Copyright Policy - CC BY-NC-ND
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4441109&req=5

fig0020: Cholecalciferol permeation profiles obtained with the diffusion cell in-vitro model. A volume of 5 ml was used for the donor phase. Dashed lines represent the linear regression for the line of best fit. Mean values ± SD (n = 3).
Mentions: Fig. 4 shows the permeation of cholecalciferol through a synthetic membrane using the diffusion cell arrangement. Based on the results from the cellulose tubing in-vitro model, formulations containing high percentages of DMSO were investigated, while ethanol formulations served as comparators. A combination of cholecalciferol concentrations and chemical penetration enhancers were used.

Bottom Line: The natural selection of anticoagulant resistant rats has resulted in a need for an alternative to anticoagulant rodenticides which differs in both active ingredient and in the method of dosing.A 1 ml dose of 50/50 (v/v) DMSO/ethanol containing 15% (v/v) PEG 200 and 20% (w/v) cholecalciferol was judged as 'sufficiently effective' in line with the European Union's Biocidal Products Regulation (No. 528/2012) during in-vivo studies.This dose was found to cause 100% mortality in a rat population in 64.4h (± 22h).

View Article: PubMed Central - PubMed

Affiliation: School of Life and Health Sciences, Aston University, Aston Triangle, Birmingham B4 7ET, UK.

No MeSH data available.


Related in: MedlinePlus