Exposure to environmental stressors result in increased viral load and further reduction of production parameters in pigs experimentally infected with PCV2b.
Bottom Line: Porcine circovirus type 2 (PCV2) has been identified as the essential, but not sole, underlying infectious component for PCV-associated diseases (PCVAD).These stressors were identified recently as risk factors leading to the occurrence of severe PCVAD on a farm level.Furthermore, all stressors led to an increased viral load in serum and tissue as assessed by qPCR, although levels did not reach statistical significance.
Affiliation: Royal Veterinary College, Department of Pathology and Pathogen Biology, Hawkshead Lane, AL9 7TA, UK.Show MeSH
Related in: MedlinePlus
Mentions: To assess whether exposure of pigs to environmental stress would impact on the viral load detected, in addition to the weight differences seen, serum (Fig. 3) and tissues samples (Fig. 4) were analysed by qPCR for PCV2 DNA. All pigs were serum PCV2b negative at week 1 post-infection and uninfected controls remained serum PCV2b negative throughout the eight-week study (Fig. 3). Viraemia in PCV2b-infected pigs always peaked at three weeks post infection and then dropped rapidly up to eight weeks post infection regardless of which environmental stressors were also applied. Interestingly, a much higher peak in serum viraemia was detected in V SD T pigs compared with V SD or V T pigs (Fig. 3), but the differences did not reach statistical significance due to large variation between pigs in the same group. These results indicate that exposure to environmental stresses potentially increases the viral load in the serum of PCV2 infected pigs.
Affiliation: Royal Veterinary College, Department of Pathology and Pathogen Biology, Hawkshead Lane, AL9 7TA, UK.