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Major pathophysiological correlations of rosacea: a complete clinical appraisal.

Vemuri RC, Gundamaraju R, Sekaran SD, Manikam R - Int J Med Sci (2015)

Bottom Line: Rosacea is a characteristic cutaneous disorder with a diverse clinical manifestations ranging from facial vascular hyper-reactivity to sebaceous gland hyperplasia.Many theories on pathophysiology of rosacea were proposed over the past decade, however the pathogenicity is poorly understood.A literature search was conducted for studies published between 1990 to March 2014.

View Article: PubMed Central - PubMed

Affiliation: 1. Department of Medical Microbiology, Faculty of Medicine, University of Malaya, Kuala Lumpur 50603, Malaysia.

ABSTRACT

Background: Rosacea is a characteristic cutaneous disorder with a diverse clinical manifestations ranging from facial vascular hyper-reactivity to sebaceous gland hyperplasia. Many theories on pathophysiology of rosacea were proposed over the past decade, however the pathogenicity is poorly understood.

Aim: To review the evidence on different pathophysiological correlations of rosacea.

Methods: A literature search was conducted for studies published between 1990 to March 2014. The inclusion criteria was pathophysiology, randomized controlled trials, controlled trials on rosacea.

Results: Out of 5141 articles, 14 high quality studies met all the selection criteria. Of 14 articles, 5 are randomized control trials (RCTs), 2 are controlled trial, 3 comparative trials, 2 observational trials, 1 prospective and 1 diagnostic trial. The studies were categorized into two groups: the trigger factors and sub-types & symptoms. Of 7 high quality studies, 4 provided strong evidence that immune responses causing disease triggered by external/internal factors such as sunlight, food and chemical agents, 3 trials provided significant evidence of microorganisms as causative agents. The remaining trials did not provide significant evidences on pathophysiology.

Conclusion: Vasculature, chronic inflammatory responses, environmental triggers, food and chemicals ingested and microorganisms either alone or in combination are responsible for rosacea. Many promising drugs are under various phases of clinical trials and interestingly, probiotics could also possibly be used as one of the treatment option.

No MeSH data available.


Related in: MedlinePlus

Mechanism of ROS resulting in inflammation 40-43.
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Figure 2: Mechanism of ROS resulting in inflammation 40-43.

Mentions: The process of neutrophils releasing the reactive oxygen species (ROS) as an early inflammatory response is postulated to have important role in rosacea 35. ROS leading to oxidative tissue damage is explained by the free radicals such as superoxide anions and hydroxyl radicals, in addition to other reactive molecules, such as molecular oxygen, hydrogen peroxide 39, 40. The following are several mechanisms which state how ROS result in skin inflammation (Figure 2) 40-43:


Major pathophysiological correlations of rosacea: a complete clinical appraisal.

Vemuri RC, Gundamaraju R, Sekaran SD, Manikam R - Int J Med Sci (2015)

Mechanism of ROS resulting in inflammation 40-43.
© Copyright Policy
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC4441063&req=5

Figure 2: Mechanism of ROS resulting in inflammation 40-43.
Mentions: The process of neutrophils releasing the reactive oxygen species (ROS) as an early inflammatory response is postulated to have important role in rosacea 35. ROS leading to oxidative tissue damage is explained by the free radicals such as superoxide anions and hydroxyl radicals, in addition to other reactive molecules, such as molecular oxygen, hydrogen peroxide 39, 40. The following are several mechanisms which state how ROS result in skin inflammation (Figure 2) 40-43:

Bottom Line: Rosacea is a characteristic cutaneous disorder with a diverse clinical manifestations ranging from facial vascular hyper-reactivity to sebaceous gland hyperplasia.Many theories on pathophysiology of rosacea were proposed over the past decade, however the pathogenicity is poorly understood.A literature search was conducted for studies published between 1990 to March 2014.

View Article: PubMed Central - PubMed

Affiliation: 1. Department of Medical Microbiology, Faculty of Medicine, University of Malaya, Kuala Lumpur 50603, Malaysia.

ABSTRACT

Background: Rosacea is a characteristic cutaneous disorder with a diverse clinical manifestations ranging from facial vascular hyper-reactivity to sebaceous gland hyperplasia. Many theories on pathophysiology of rosacea were proposed over the past decade, however the pathogenicity is poorly understood.

Aim: To review the evidence on different pathophysiological correlations of rosacea.

Methods: A literature search was conducted for studies published between 1990 to March 2014. The inclusion criteria was pathophysiology, randomized controlled trials, controlled trials on rosacea.

Results: Out of 5141 articles, 14 high quality studies met all the selection criteria. Of 14 articles, 5 are randomized control trials (RCTs), 2 are controlled trial, 3 comparative trials, 2 observational trials, 1 prospective and 1 diagnostic trial. The studies were categorized into two groups: the trigger factors and sub-types & symptoms. Of 7 high quality studies, 4 provided strong evidence that immune responses causing disease triggered by external/internal factors such as sunlight, food and chemical agents, 3 trials provided significant evidence of microorganisms as causative agents. The remaining trials did not provide significant evidences on pathophysiology.

Conclusion: Vasculature, chronic inflammatory responses, environmental triggers, food and chemicals ingested and microorganisms either alone or in combination are responsible for rosacea. Many promising drugs are under various phases of clinical trials and interestingly, probiotics could also possibly be used as one of the treatment option.

No MeSH data available.


Related in: MedlinePlus