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Major pathophysiological correlations of rosacea: a complete clinical appraisal.

Vemuri RC, Gundamaraju R, Sekaran SD, Manikam R - Int J Med Sci (2015)

Bottom Line: Rosacea is a characteristic cutaneous disorder with a diverse clinical manifestations ranging from facial vascular hyper-reactivity to sebaceous gland hyperplasia.Many theories on pathophysiology of rosacea were proposed over the past decade, however the pathogenicity is poorly understood.A literature search was conducted for studies published between 1990 to March 2014.

View Article: PubMed Central - PubMed

Affiliation: 1. Department of Medical Microbiology, Faculty of Medicine, University of Malaya, Kuala Lumpur 50603, Malaysia.

ABSTRACT

Background: Rosacea is a characteristic cutaneous disorder with a diverse clinical manifestations ranging from facial vascular hyper-reactivity to sebaceous gland hyperplasia. Many theories on pathophysiology of rosacea were proposed over the past decade, however the pathogenicity is poorly understood.

Aim: To review the evidence on different pathophysiological correlations of rosacea.

Methods: A literature search was conducted for studies published between 1990 to March 2014. The inclusion criteria was pathophysiology, randomized controlled trials, controlled trials on rosacea.

Results: Out of 5141 articles, 14 high quality studies met all the selection criteria. Of 14 articles, 5 are randomized control trials (RCTs), 2 are controlled trial, 3 comparative trials, 2 observational trials, 1 prospective and 1 diagnostic trial. The studies were categorized into two groups: the trigger factors and sub-types & symptoms. Of 7 high quality studies, 4 provided strong evidence that immune responses causing disease triggered by external/internal factors such as sunlight, food and chemical agents, 3 trials provided significant evidence of microorganisms as causative agents. The remaining trials did not provide significant evidences on pathophysiology.

Conclusion: Vasculature, chronic inflammatory responses, environmental triggers, food and chemicals ingested and microorganisms either alone or in combination are responsible for rosacea. Many promising drugs are under various phases of clinical trials and interestingly, probiotics could also possibly be used as one of the treatment option.

No MeSH data available.


Related in: MedlinePlus

Flow diagram for selection process.
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Figure 1: Flow diagram for selection process.

Mentions: The literature search yielded 5141(n) articles from various databases with 2461 articles from PubMed, 1461 articles from EMBASE, 1000 articles from MEDLINE®. Cochrane CENTRAL was also used for the search of literature, which yielded 209 completed and on-going articles. 10 articles were considered from other sources. The articles left after duplicates are removed and total articles screened are 2680. Applying inclusion and exclusion criteria, 2627 articles were excluded, leaving 53 full-text articles under eligibility criterion. 35 full-text articles were excluded from selected 53, as they do not fit for the literature. 14 full-text research articles were included for high quality synthesis. Figure 1 depicts the flow diagram of selection process. Out of 14 articles, 5 are randomized control trials (RCTs), 2 are controlled trial, 3 comparative trials, 2 observational trials, 1 prospective and 1 diagnostic trial. The 14 studies selected are conducted all over the world, 5 trials are from USA, U.K (with 1 multicenter) and 3 trials are from France, and one each from Ireland, Germany, Croatia, Georgia, Italy and Libya. The sample size from all the studies ranging from n= 20 to n= 504. Included trials have got subjects from young to middle age, which helped us to correlate the occurrence of the disease in different age groups. Table 1describes the detailed description of trials included.


Major pathophysiological correlations of rosacea: a complete clinical appraisal.

Vemuri RC, Gundamaraju R, Sekaran SD, Manikam R - Int J Med Sci (2015)

Flow diagram for selection process.
© Copyright Policy
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC4441063&req=5

Figure 1: Flow diagram for selection process.
Mentions: The literature search yielded 5141(n) articles from various databases with 2461 articles from PubMed, 1461 articles from EMBASE, 1000 articles from MEDLINE®. Cochrane CENTRAL was also used for the search of literature, which yielded 209 completed and on-going articles. 10 articles were considered from other sources. The articles left after duplicates are removed and total articles screened are 2680. Applying inclusion and exclusion criteria, 2627 articles were excluded, leaving 53 full-text articles under eligibility criterion. 35 full-text articles were excluded from selected 53, as they do not fit for the literature. 14 full-text research articles were included for high quality synthesis. Figure 1 depicts the flow diagram of selection process. Out of 14 articles, 5 are randomized control trials (RCTs), 2 are controlled trial, 3 comparative trials, 2 observational trials, 1 prospective and 1 diagnostic trial. The 14 studies selected are conducted all over the world, 5 trials are from USA, U.K (with 1 multicenter) and 3 trials are from France, and one each from Ireland, Germany, Croatia, Georgia, Italy and Libya. The sample size from all the studies ranging from n= 20 to n= 504. Included trials have got subjects from young to middle age, which helped us to correlate the occurrence of the disease in different age groups. Table 1describes the detailed description of trials included.

Bottom Line: Rosacea is a characteristic cutaneous disorder with a diverse clinical manifestations ranging from facial vascular hyper-reactivity to sebaceous gland hyperplasia.Many theories on pathophysiology of rosacea were proposed over the past decade, however the pathogenicity is poorly understood.A literature search was conducted for studies published between 1990 to March 2014.

View Article: PubMed Central - PubMed

Affiliation: 1. Department of Medical Microbiology, Faculty of Medicine, University of Malaya, Kuala Lumpur 50603, Malaysia.

ABSTRACT

Background: Rosacea is a characteristic cutaneous disorder with a diverse clinical manifestations ranging from facial vascular hyper-reactivity to sebaceous gland hyperplasia. Many theories on pathophysiology of rosacea were proposed over the past decade, however the pathogenicity is poorly understood.

Aim: To review the evidence on different pathophysiological correlations of rosacea.

Methods: A literature search was conducted for studies published between 1990 to March 2014. The inclusion criteria was pathophysiology, randomized controlled trials, controlled trials on rosacea.

Results: Out of 5141 articles, 14 high quality studies met all the selection criteria. Of 14 articles, 5 are randomized control trials (RCTs), 2 are controlled trial, 3 comparative trials, 2 observational trials, 1 prospective and 1 diagnostic trial. The studies were categorized into two groups: the trigger factors and sub-types & symptoms. Of 7 high quality studies, 4 provided strong evidence that immune responses causing disease triggered by external/internal factors such as sunlight, food and chemical agents, 3 trials provided significant evidence of microorganisms as causative agents. The remaining trials did not provide significant evidences on pathophysiology.

Conclusion: Vasculature, chronic inflammatory responses, environmental triggers, food and chemicals ingested and microorganisms either alone or in combination are responsible for rosacea. Many promising drugs are under various phases of clinical trials and interestingly, probiotics could also possibly be used as one of the treatment option.

No MeSH data available.


Related in: MedlinePlus