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The effect of therapeutic lumbar punctures on acute mortality from cryptococcal meningitis.

Rolfes MA, Hullsiek KH, Rhein J, Nabeta HW, Taseera K, Schutz C, Musubire A, Rajasingham R, Williams DA, Thienemann F, Muzoora C, Meintjes G, Meya DB, Boulware DR - Clin. Infect. Dis. (2014)

Bottom Line: The adjusted relative risk of mortality was 0.31 (95% confidence interval: .12-.82).The association was observed regardless of opening pressure at baseline.Therapeutic LPs were associated with a 69% relative improvement in survival, regardless of initial intracranial pressure.

View Article: PubMed Central - PubMed

Affiliation: Department of Medicine, Medical School.

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Time of the first therapeutic LP in days from diagnosis of cryptococcal meningitis, among 75 HIV-infected individuals in South Africa and Uganda who received at least 1 LP after an initial diagnostic LP. The median time after diagnosis until the first therapeutic LP was 3 days. Abbreviations: HIV, human immunodeficiency virus; LP, lumbar puncture.
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CIU596F2: Time of the first therapeutic LP in days from diagnosis of cryptococcal meningitis, among 75 HIV-infected individuals in South Africa and Uganda who received at least 1 LP after an initial diagnostic LP. The median time after diagnosis until the first therapeutic LP was 3 days. Abbreviations: HIV, human immunodeficiency virus; LP, lumbar puncture.

Mentions: Seventy-five (30%) subjects received at least 1 therapeutic LP after diagnosis. The median baseline ICP at diagnosis was 269 mmH2O (IQR: 180–373 mmH2O) and was significantly higher among individuals who later received a therapeutic LP (Table 1). The majority of individuals (80%) receiving a therapeutic LP underwent only 1 LP during follow-up, although 15 individuals had ≥2 LPs including 2 individuals who received 7 LPs and 1 individual who received 8 LPs during the observation period. The median time to first therapeutic LP was 3 days after diagnosis (IQR: 2–4 days; Figure 2).Table 1.


The effect of therapeutic lumbar punctures on acute mortality from cryptococcal meningitis.

Rolfes MA, Hullsiek KH, Rhein J, Nabeta HW, Taseera K, Schutz C, Musubire A, Rajasingham R, Williams DA, Thienemann F, Muzoora C, Meintjes G, Meya DB, Boulware DR - Clin. Infect. Dis. (2014)

Time of the first therapeutic LP in days from diagnosis of cryptococcal meningitis, among 75 HIV-infected individuals in South Africa and Uganda who received at least 1 LP after an initial diagnostic LP. The median time after diagnosis until the first therapeutic LP was 3 days. Abbreviations: HIV, human immunodeficiency virus; LP, lumbar puncture.
© Copyright Policy - creative-commons
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4441057&req=5

CIU596F2: Time of the first therapeutic LP in days from diagnosis of cryptococcal meningitis, among 75 HIV-infected individuals in South Africa and Uganda who received at least 1 LP after an initial diagnostic LP. The median time after diagnosis until the first therapeutic LP was 3 days. Abbreviations: HIV, human immunodeficiency virus; LP, lumbar puncture.
Mentions: Seventy-five (30%) subjects received at least 1 therapeutic LP after diagnosis. The median baseline ICP at diagnosis was 269 mmH2O (IQR: 180–373 mmH2O) and was significantly higher among individuals who later received a therapeutic LP (Table 1). The majority of individuals (80%) receiving a therapeutic LP underwent only 1 LP during follow-up, although 15 individuals had ≥2 LPs including 2 individuals who received 7 LPs and 1 individual who received 8 LPs during the observation period. The median time to first therapeutic LP was 3 days after diagnosis (IQR: 2–4 days; Figure 2).Table 1.

Bottom Line: The adjusted relative risk of mortality was 0.31 (95% confidence interval: .12-.82).The association was observed regardless of opening pressure at baseline.Therapeutic LPs were associated with a 69% relative improvement in survival, regardless of initial intracranial pressure.

View Article: PubMed Central - PubMed

Affiliation: Department of Medicine, Medical School.

Show MeSH
Related in: MedlinePlus