The effect of therapeutic lumbar punctures on acute mortality from cryptococcal meningitis.
Bottom Line: The adjusted relative risk of mortality was 0.31 (95% confidence interval: .12-.82).The association was observed regardless of opening pressure at baseline.Therapeutic LPs were associated with a 69% relative improvement in survival, regardless of initial intracranial pressure.
Affiliation: Department of Medicine, Medical School.Show MeSH
Related in: MedlinePlus
Mentions: Seventy-five (30%) subjects received at least 1 therapeutic LP after diagnosis. The median baseline ICP at diagnosis was 269 mmH2O (IQR: 180–373 mmH2O) and was significantly higher among individuals who later received a therapeutic LP (Table 1). The majority of individuals (80%) receiving a therapeutic LP underwent only 1 LP during follow-up, although 15 individuals had ≥2 LPs including 2 individuals who received 7 LPs and 1 individual who received 8 LPs during the observation period. The median time to first therapeutic LP was 3 days after diagnosis (IQR: 2–4 days; Figure 2).Table 1.